Brain mitochondrial responses to postischemic reperfusion: A role for calcium and hydrogen peroxide?

Developmental Neuroscience

Volumn 22, Issue 5-6, 2000, Pages 366-375

  Sims, Neil R ^a   Anderson, Michelle F ^a   Hobbs, Leanne M ^a   Powell, Jason A ^a   Zaidan, Emad ^a  

^a FLINDERS UNIVERSITY   (Australia)

Author keywords

Calcium; FK506; Glutathione; Hydrogen peroxide; Ischemia; Mitochondria; Oxidative phosphorylation; Permeability transition

Indexed keywords

CALCIUM ION; CYCLOSPORIN A; GLUTATHIONE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; TACROLIMUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CIRCULATION; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; CALCIUM CELL LEVEL; CELL ISOLATION; CELL MEMBRANE PERMEABILITY; CELL ORGANELLE; CONTROLLED STUDY; FOREBRAIN; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION;

ADENOSINE DIPHOSPHATE; ANIMALS; BRAIN ISCHEMIA; CALCIUM; CARBONYL CYANIDE M-CHLOROPHENYL HYDRAZONE; CELL RESPIRATION; CYCLOSPORINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLUTATHIONE; HYDROGEN PEROXIDE; MALATES; MALE; MITOCHONDRIA; OXYGEN CONSUMPTION; PROSENCEPHALON; PYRUVIC ACID; RATS; RATS, INBRED STRAINS; REPERFUSION; SUCCINIC ACID; TACROLIMUS; TERT-BUTYLHYDROPEROXIDE; UNCOUPLING AGENTS;

EID: 0033662647     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000017462     Document Type: Article

References (46)

1. Akerboom TPM, Sies H (1981): Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples. Methods Enzymol 77:373-382.
2. Canevari L, Kuroda S, Bates TE, Clark JB, Siesjö BK (1997): Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat. J Cereb Blood Flow Metab 17: 1166-1169.
3. Chen J, Nagayama T, Jin KL, Stetler RA, Zhu RL, Graham SH, Simon RP (1998): Induction of caspase-3 like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 18:4914-4928.
4. Crompton M (1999): The mitochondrial permeability transition pore and its role in cell death. Biochem J 341:233-249.
5. Drake M, Friberg H, Boris-Moller F, Sakata K, Wieloch T (1996): The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain. Acta Physiol Scand 158:155-159.
6. Dux E, Mies G, Hossmann K-A, Siklos L (1987): Calcium in the mitochondria following brief ischemia of gerbil brain. Neurosci Lett 78:295-300.
7. Fiskum G, Murphy AN, Beal MF (1999): Mitochondria in neurodegeneration: Acute ischemia and chronic neurodegenerative diseases. J Cereb Blood Flow Metab 19:351-369.
8. Friberg H, Ferrand-Drake M, Bengtsson F, Halestrap AP, Wieloch T (1998): Cyclosporin A, but not FK506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death. J Neurosci 18:5151-5159.
9. Fujimura M, Moritafujimura Y, Murakami K, Kawase M, Chan PH (1998): Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 18:1239-1247.
10. Griffith OW (1980): Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106:207-212.
11. Griffiths EJ, Halestrap AP (1991): Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Biochem J 274:611-614.
12. Halliwell B (1992): Reactive oxygen species and the central nervous system. J Neurochem 59: 1609-1623.
13. 2 in vitro. Brain Res 671:181-186.
14. Kristal BS, Dubinsky JM (1997): Mitochondrial permeability transition in the central nervous system: Induction by calcium cycling-dependent and -independent pathways. J Neurochem 69:524-538.
15. Lipton P (1999): Ischemic cell death in brain neurons. Physiol Rev 79:1431-1568.
16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951): Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
17. Meister A (1995): Mitochondrial changes associated with glutathione deficiency. Biochim Biophys Acta 1271:35-42.
18. Mignotte B, Vayssière J-L (1998): Mitochondria and apoptosis. Eur J Biochem 252:1-15.
19. Murphy AN, Fiskum G, Beal MF (1999): Mitochondria in neurodegeneration: Bioenergetic function in cell life and death. J Cereb Blood Flow Metab 19:231-245.
20. Nelson CW, Wei EP, Povlishock JT, Kontos HA, Moskowitz MA (1992): Oxygen radicals in cerebral ischemia. Am J Physiol 263:H1356-H1362.
21. Pulsinelli WA, Brierly JB, Plum F (1982a): Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11: 491-498.
22. Pulsinelli WA, Duffy TE (1983): Regional energy balance in rat brain after transient forebrain ischemia. J Neurochem 40:1500-1503.
23. Pulsinelli WA, Levy DE, Duffy TE (1982b): Regional cerebral blood flow and glucose metabolism following transient cerebral ischemia. Ann Neurol 11:499-509.
24. Scanlon JM, Reynolds IJ (1998): Effects of oxidants and glutamate receptor activation on mitochondrial membrane potential in rat forebrain neurons. J Neurochem 71:2392-2400.
25. Schinder AF, Olson EC, Spitzer NC, Montal M (1996): Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J Neurosci 16:5688-5697.
26. Sharkey J, Butcher SP (1994): Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischemia. Nature 371:336-339.
27. Sies H (1985): Hydroperoxides and thiol oxidants in the study of oxidative stress in intact cells and organs; in Sies H (ed): Oxidative Stress. London, Academic Press, pp 73-90.
28. Simonian NA, Coyle JT (1996): Oxidative stress in neurodegenerative diseases. Annu Rev Pharmacol Toxicol 36:83-106.
29. Simonson SG, Zhang J, Canada AT, Su Y-F, Benveniste H, Piantadosi CA (1993): Hydrogen peroxide production by monoamine oxidase during ischemia-reperfusion in the rat brain. J Cereb Blood Flow Metab 13:125-134.
30. Sims NR (1990): Rapid isolation of metabolically active mitochondria from rat brain and subregions using Percoll density gradient centrifugation. J Neurochem 55:698-707.
31. Sims NR (1991): Selective impairment of respiration in mitochondria isolated from brain subregions following transient forebrain ischemia in the rat. J Neurochem 56:1836-1844.
32. Sims NR, Anderson MF, Hobbs LM, Kong JY, Phillips S, Powell JA, Zaidan E (2000): Inhibition of brain mitochondrial function by hydrogen peroxide. Mol Brain Res 77:176-184.
33. Sims NR, Pulsinelli WA ( 1987): Altered mitochondrial respiration in selectively vulnerable brain subregions following transient forebrain ischemia in the rat. J Neurochem 49:1367-1374.
34. Sims NR, Williams VK, Zaidan E, Powell JA (1998): The antioxidant defences of brain mitochondria during short-term forebrain ischemia and recirculation in the rat. Mol Brain Res 60: 141-149.
35. Susin SA, Zamzami N, Kroemer G (1998): Mitochondria as regulators of apoptosis: Doubt no more. Biochim Biophys Acta 1366:151-165.
36. Vlessis AA (1990): NADH-linked substrate dependence of peroxide-induced respiratory inhibition and calcium efflux in isolated renal mitochondria. J Biol Chem 265:1448-1453.
37. Vlessis AA, Widener LL, Bartos D (1990): Effect of peroxide, sodium, and calcium on brain mitochondrial respiration in vitro: Potential role in cerebral ischemia and reperfusion. J Neurochem 54:1412-1418.
38. Yoshimoto T, Siesjö BK (1999): Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia. Brain Res 839:283-291.
39. Zaidan E, Nilsson M, Sims NR ( 1999): Cyclosporin A-sensitive changes in mitochondrial glutathione are an early response to intrastriatal NMDA or forebrain ischemia in rats. J Neurochem 73:2214-2217.
40. Zaidan E, Sheu K-FR, Sims NR (1998): The pyruvate dehydrogenase complex is partially inactivated during early recirculation following short-term forebrain ischemia in rats. J Neurochem 70:233-241.
41. 14C]glucose in brain subregions following transient forebrain ischemia in the rat. J Neurochem 55:1882-1889.
42. Zaidan E, Sims NR (1993): Selective reductions in the activity of the pyruvate dehydrogenase complex in mitochondria isolated from brain subregions following forebrain ischemia in rats. J Cereb Blood Flow Metab 13:98-104.
43. Zaidan E, Sims NR (1994): The calcium content of mitochondria from brain subregions following short term forebrain ischemia and recirculation in the rat. J Neurochem 63:1812-1819.
44. Zaidan E, Sims NR (1996): Alterations in the glutathione content of mitochondria following short-term forebrain ischemia in rats. Neurosci Lett 218:75-78.
45. 2-adrenoceptors inhibits apoptosis in rat brain after transient forebrain ischemia. J Cereb Blood Flow Metab 18: 1032-1039.
46. Zoratti M, Szabo I (1995): The mitochondrial permeability transition. Biochem Biophys Acta 1241:139-176.