Placental defects in ARNT-knockout conceptus correlate with localized decreases in VEGF-R2, Ang-1, and Tie-2

Developmental Dynamics

Volumn 219, Issue 4, 2000, Pages 526-538

  Abbott, Barbara D ^a   Buckalew, Angela R ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Angiopoietin; ARNT; Placenta; Tie 2; Vasculogenesis; VEGF

Indexed keywords

ANGIOPOIETIN 1; AROMATIC HYDROCARBON RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIGAND; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIMERIZATION; ENDOTHELIUM CELL; GENOTYPE; GIANT CELL; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PLACENTA DISORDER; PRIORITY JOURNAL; RECEPTOR BINDING; YOLK SAC;

ANGIOPOIETIN-1; ANGIOPOIETIN-2; ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; DNA-BINDING PROTEINS; EMBRYO; EMBRYONIC AND FETAL DEVELOPMENT; ENDOTHELIAL GROWTH FACTORS; FEMALE; IMMUNOHISTOCHEMISTRY; LYMPHOKINES; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; NEUROPILIN-1; PLACENTA; PREGNANCY; PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TIE-2; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RECOMBINANT PROTEINS; TRANSCRIPTION FACTORS; TROPHOBLASTS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA;

EID: 0033662205     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1080>3.0.CO;2-N     Document Type: Article

References (46)

1. Developmental expression of two members of a new class of transcription factors: II. Expression of aryl hydrocarbon receptor nuclear translocator in the C57BL/6N mouse embryo
2. Developmental expression of two members of a new class of transcription factors: I. Expression of aryl hydrocarbon receptor in the C57BL/6N mouse embryo
3. Multilineage embryonic hematopoiesis requires hypoxic ARNT activity
4. Profound effects on vascular development caused by perturbations during organogenesis
5. Coordinate expression of vascular endothelial growth factor receptor-1 (flt-1) and its ligand suggests a paracrine regulation of murine vascular development
6. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
7. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
8. Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development
9. Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT)
10. Vascularization of the mouse embryo: A study of flk-1, tek, tie, and vascular endothelial growth factor expression during development
11. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
12. Vascular endothelial growth factor
13. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
14. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
15. Regulation of flt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium
16. Identification of functional domains of the aryl hydrocarbon receptor
17. Signaling vascular morphogenesis and maintenance
18. Cloning of a factor required for activity of the Ah (dioxin) receptor
19. Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse
20. Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis
21. A requirement for neuropilin-1 in embryonic vessel formation
22. Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
23. ARNT-deficient mice and placental differentiation
24. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
25. Oxygen, genes, and development: An analysis of the role of hypoxic gene regulation during murine vascular development
26. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
27. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
28. Multiple developmental roles of VEGF suggested by a LacZ-tagged allele
29. Vascular endothelial growth factor (VEGF) and its receptors
30. Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth
31. Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT)
32. HIF-1 alpha is required for solid tumor formation and embryonic vascularization
33. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
34. Ah receptor signaling pathways
35. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
36. Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis
37. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
38. Increased vascularization in mice overexpressing angiopoietin-1
39. Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock
40. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
41. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
42. Purification and characterization of hypoxia-inducible factor 1
43. Oxygen(es) and the hypoxia-inducible factor-1
44. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells