Modes of allosteric interactions with free and [3H]N-methylscopolamine-occupied muscarinic M2 receptors as deduced from buffer-dependent potency shifts

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 362, Issue 6, 2000, Pages 512-519

  Schroter, A ^a   Trankle, C ^a   Mohr, K ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

3H N methylscopolamine; Alcuronium; Allosteric modulation; Buffer dependence; Duo3; Gallamine; Muscarinic acetylcholine receptor; WDuo3

Indexed keywords

ALCURONIUM; BIS(PYRIDINIUM OXIME) DERIVATIVE; GALLAMINE; METHYLSCOPOLAMINE; MUSCARINIC M2 RECEPTOR;

ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; DISSOCIATION CONSTANT; DRUG POTENCY; LIGAND BINDING; NONHUMAN; PROTEIN INTERACTION; RECEPTOR OCCUPANCY; SWINE;

ALCURONIUM; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BUFFERS; CHOLINERGIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GALLAMINE TRIETHIODIDE; KINETICS; MUSCARINIC ANTAGONISTS; MYOCARDIUM; N-METHYLSCOPOLAMINE; NICOTINIC AGONISTS; PYRIDINIUM COMPOUNDS; RECEPTOR, MUSCARINIC M2; RECEPTORS, MUSCARINIC; SWINE; TRITIUM;

EID: 0033653623     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100000316     Document Type: Article

References (23)

1. Neurotransmitter, hormone, or drug receptor binding methods
2. 2 receptors
3. Estimation of the affinities of allosteric ligands using radioligand binding and pharmacologic null methods
4. Two allosteric modulators interact at a common site on cardiac muscarinic receptors
5. Competitive and allosteric interactions of 6-chloro-5,10,dihydro-5-[(1-methyl-4-piperidinyl) acetyl]-11H-dibenzo[b,e][1,4]diazepine-11-one hydrochloride (UH-AH 37) at muscarinic receptors, via distinct epitopes
6. Allosteric regulation of cloned m1-m5 muscarinic receptor subtypes
7. Allosteric modulators of ligand binding to muscarinic acetylcholine receptors
8. Protection by alcuronium of muscarinic receptors against chemical inactivation and location of the allosteric binding site for alcuronium
9. Positive allosteric interactions on cardiac muscarinic receptors: Effects of chemical modifications of disulphide and carboxyl groups
10. Composite action of allosteric modulators on ligand binding
11. 2 receptors
12. Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: Interactions of strychnine and acetylcholine at muscarinic receptors
13. Allosteric antagonists of the muscarinic acetylcholine receptor
14. Role of acidic amino acids in the allosteric modulation by gallamine of antagonist binding at the m2 muscarinic acetylcholine receptor
15. Protein measurement with the folin phenol reagent
16. Mechanisms of steric and cooperative actions of alcuronium on cardiac muscarinic acetylcholine receptors
17. 2 receptors
18. Search for lead structures to develop new allosteric modulators of muscarinic receptors
19. 2 receptors
20. Allosteric modulation of muscarinic acetylcholine receptors
21. Positive cooperativity in the binding of alcuronium and N-methylscopolamine to muscarinic acetylcholine receptors
22. Identification of drugs competing with d-tubocurarine for an allosteric site on cardiac muscarinic receptors
23. Molecular biology of muscarinic acetylcholine receptors