Mutation of the Secys residue 266 in human type 2 selenodeiodinase alters 75Se incorporation without affecting its biochemical properties

Biochimie

Volumn 81, Issue 5, 1999, Pages 535-538

  Salvatore, Domenico ^a   Harney, John W ^a   Reed Larsen, P ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

75Se incorporation; Biochemical properties; Mutation; Selenodeiodinase

Indexed keywords

CYSTEINE; MUTANT PROTEIN; SELENIUM; SELENOCYSTEINE;

ARTICLE; CODON; GENE MUTATION; STOP CODON;

EID: 0032730384     PISSN: 03009084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-9084(99)80106-0     Document Type: Article

References (12)

1. Larsen P.R. The Thyroid and its Diseases. Thyroid hormone transport, cellular uptake, metabolism and molecular action. in: Churchill Livingstone Inc., New York :1996;61-111.
2. Berry M.J., Banu L., Larsen P.R. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature. 349:1991;438-440.
3. Croteau W., Davey J.C., Galton V.A., St. Germain D.L. Cloning of the mammalian type II iodothyronine deiodinase: a selenoprotein differentially expressed and regulated in human and rat brain and other tissues. J. Clin. Invest. 98:1996;405-417.
4. Salvatore D., Tu H., Harney J.W., Larsen P.R. Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J. Clin. Invest. 98:1996;962-968.
5. Salvatore D., Bartha T., Harney J.W., Larsen P.R. Molecular biological and biochemical characterization of the human type 2 selenodeiodinase. Endocrinology. 137:1996;3308-3315.
6. Low S.C., Berry M.J. Knowing when not to stop: selenocysteine incorporation in eukaryotes. Trends Biochem. Sci. 21:1996;203-208.
7. Berry M.J., Banu L., Chen Y., Mandel S.J., Kieffer J.D., Harney J.W., Larsen P.R. Recognition of UGA as a selenocysteine codon in Type I deiodinase requires sequences in the 3' untranslated region. Nature. 353:1991;273-276.
8. Brent G.A., Larsen P.R., Harney J.W., Koenig R.J., Moore D.D. Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor. J. Biol. Chem. 264:1989;178-182.
9. Toyoda N., Harney J.W., Berry M.J., Larsen P.R. Identification of critical amino acids for 3,5',3'-triiodothyronine deiodination by human type I deiodinase based on comparative functional-structural analyses of the human, dog, and rat enzymes. J. Biol. Chem. 269:1994;20329-20334.
10. Berry M.J., Harney J.W., Ohama T., Hatfield D.L. Selenocysteine insertion or termination: factors affecting UGA codon fate and complementary anticodon: codon mutations. Nucleic Acids Res. 22:1994;3753-3759.
11. McCaughan K.K., Brown C.M., Dalphin M.E., Berry M.J., Tate W.P. Translational termination efficiency in mammals is influenced by the base following the stop codon. Proc. Natl. Acad. Sci. USA. 92:1995;5431-5435.
12. Pallud S., Lennon A.M., Ramauge M., Gavaret J.M., Croteau W., Pierre M., Courtin F., St. Germain D.L., St. Germain D.L. Expression of the type II iodothyronine deiodinase in cultured rat astrocytes is selenium-dependent. J. Biol. Chem. 272:1997;18104-18110.