Role of cyclooxygenase-2 in modulating gastric acid secretion in the normal and inflamed rat stomach

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 279, Issue 6 42-6, 2000, Pages

  Barnett, Kirsty ^a   Bell, Cameron J ^b   McKnight, Webb ^a   Dicay, Michael ^a   Sharkey, Keith A ^a   Wallace, John L ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

Gastritis; Inflammation; Mucosa; Prostaglandin

Indexed keywords

5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; CYCLOOXYGENASE 2; INDOMETACIN; IODOACETAMIDE; MYELOPEROXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; GASTRITIS; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; STOMACH ACID SECRETION; STOMACH MUCOSA; STOMACH ULCER; ULCER HEALING;

EID: 0033638131     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.279.6.g1292     Document Type: Article

References (38)

1. Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration
2. Prolonged colonic epithelial hyporesponsiveness after colitis: Role of inducible nitric oxide
3. L-745,337: A selective inhibitor of cyclooxygenase-2 elicits anti-nociception but not gastric ulceration in rats
4. Aspirin induces a rapid up-regulation of cyclooxy genase- 2 expression in the rat stomach
5. The role of endogenous prostaglandins in the regulation of gastric secretion in rhesus monkeys
6. Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease
7. Eradicating Helicobacter pylori infection lowers gastrin mediated acid secretion by two thirds in patients with duodenal ulcer disease
8. Effect of indomethacin on gastric acid and bicarbonate secretion in humans
9. Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: Role in resistance to damage
10. Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis
11. Ablation of exaggerated meal-stimulated gastrin release in duodenal ulcer patients after clearance of Helicobacter (Campylobacter) pylori infection
12. Selective cyclo-oxygenase- 2 inhibitors and their influence on the protective effect of a mild irritant in the rat stomach
13. Eradication of Helicobacter pylori in patients with duodenal ulcer lowers basal and peak outputs to gastric releasing peptide and pentagastrin
14. Role of prostaglandins in regulation of gastric mucosal blood flow and acid secretion
15. Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey and human gastrointestinal tracts
16. A randomized trial comparing the effect of rofecoxib, a cyclooxygenase-2 specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis
17. Effect of indomethacin on basal and histamine-stimulated human gastric acid secretion
18. Prostaglandins mediate inhibition of gastric acid secretion by somatostatin in the rat
19. Selective inhibition of inducible cyclooxygenase in vivo is antiinflammatory and nonulcerogenic
20. Selective COX-2 inhibitors and human inflammatory bowel disease
21. Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by specific antagonist delays healing in mice
22. Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase- 2
23. Cytoprotection by prostaglandins
24. Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats
25. Influence of acid and angiogenesis on kinetics of gastric ulcer healing in rats: Interaction with indomethacin
26. Indomethacin enhances histamine-stimulated acid production in rabbit isolated fundic glands
27. Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis. A randomized controlled trial
28. Mechanisms of action of antisecretory drugs: Studies on isolated canine fundic mucosal cells
29. Diclofenac delays healing of gastroduodenal mucosal lesions: Double-blind, placebo-controlled endoscopic study in healthy volunteers
30. Sulfhydryl blockers induce severe inflammatory gastritis in the rat
31. Famotidine for healing and maintenance in nonsteroidal antiinflammatory drug-associated gastroduodenal ulceration
32. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
33. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation and pain
34. Nonsteroidal anti-inflammatory drugs and gastroenteropathy: The second hundred years
35. Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity
36. Limited anti-inflammatory efficacy of cyclooxygenase-2 inhibition in carrageenan-airpouch inflammation
37. Secretagogue-specific effects of interleukin- 1 on gastric acid secretion
38. NSAID-induced gastric damage: Requirement for inhibition of both cyclooxygenase-1 and - 2