Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus

Molecular Cell

Volumn 6, Issue 1, 2000, Pages 149-158

  Enemark, Eric J ^a,b   Chen, Grace ^b,c   Vaughn, Daniel E ^a,b   Stenlund, Arne ^b   Joshua Tor, Leemor ^a,b  

^a W M Keck Structural Biology Laboratory   (United States)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HELIX LOOP HELIX PROTEIN; INITIATION FACTOR;

ALPHA HELIX; ARTICLE; BENIGN TUMOR; CRYSTAL STRUCTURE; DIMERIZATION; DNA BINDING; GENE MUTATION; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR MODEL; NONHUMAN; PAPILLOMA VIRUS; PROTEIN DNA INTERACTION; UTERINE CERVIX CARCINOMA; VIRUS INFECTION; VIRUS REPLICATION;

PAPILLOMAVIRUS;

EID: 0033634815     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(05)00016-X     Document Type: Article

References (65)

1. A fast algorithm for rendering space-filling molecule pictures
2. Amino-terminal domains of the bovine papillomavirus type 1 E1 and E2 proteins participate in complex formation
3. Helicases: A unifying structural theme?
4. Bovine papillomavirus E1 protein binds specifically DNA polymerase α but not replication protein
5. Crystallography and NMR system: A new software suite for macromolecular structure determination
6. Characterization of the DNA-binding domain of the bovine papillomavirus replication initiator E1
7. Two patches of amino acids on the E2 DNA binding domain define the surface for interaction with E1
8. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
9. Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral origins
10. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
11. A common function for polyoma virus large-T and papillomavirus E1 proteins?
12. The CCP4 suite: Programs for protein crystallography
13. Human papillomavirus DNA replication. Interactions between the viral E1 protein and two subunits of human DNA polymerase primase
14. Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods
15. Transient replication of human papillomavirus DNAs
16. Bacteriophage T7 helicase/primase proteins form rings around single-stranded DNA that suggest a general structure for hexameric helicases
17. An extensively modified version of MolScript that includes greatly enhanced coloring capabilities
18. Genetic analysis of the activation domain of bovine papillomavirus protein E2: Its role in transcription and replication
19. Biochemical and electron microscopic image analysis of the hexameric E1 helicase
20. Structure of NF-κB p50 homodimer bound to a κB site
21. Induction of structural changes in the bovine papillomavirus type 1 origin of replication by the viral E1 and E2 proteins
22. Separate domains in E1 and E2 proteins serve architectural and productive roles for cooperative DNA binding
23. Identification of a short, hydrophilic amino acid sequence critical for origin recognition by the bovine papillomavirus E1 protein
24. Crystal Structure at 1.7 Å of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target
25. Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): A vehicle for direct determination of three-dimensional structure
26. Natural history of cervicovaginal papilloma virus infection in young women
27. Improved methods for building protein models in electron density maps and the location of errors in these models
28. Detection, delineation, measurement and display of cavities in macromolecular structures
29. Phi/Psi-chology: Ramachandran revisited
30. Detecting folding motifs and similarities in protein structures
31. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
32. Mechanisms of helicase-catalyzed DNA unwinding
33. Solution structure of the origin DNA-binding domain of SV40 T-antigen
34. The bovine papillomavirus E2 protein modulates the assembly but is not stably maintained in a replication-competent multimeric E1-replication origin complex
35. The bovine papillomavirus E1 protein has ATPase activity essential to viral DNA replication and efficient transformation in cells
36. Bovine papillomavirus type 1 E1 and simian virus 40 large T-antigen share regions of sequence similarity required for multiple functions
37. A C-terminal helicase domain of the human pappilomavirus E1 protein binds E2 and the DNA polymerase α-primase p68 subunit
38. ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication
39. The E2 proteins
40. Raster3D version 2.0 - A program for photorealistic molecular graphics
41. Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator
42. Structure of the NF-κB p50 homodimer bound to DNA
43. Protein folding and association - Insights from the interfacial and thermodynamic properties of hydrocarbons
44. Processing of X-ray diffraction data collected in oscillation mode
45. The cellular DNA polymerase α-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase
46. Automated protein model building combined with iterative structure refinement
47. Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions
48. Recruitment and loading of the E1 initiator protein: An ATP-dependent process catalyzed by a transcription factor
49. Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator-specific DNA replication of bovine papillomavirus in vivo and in vitro
50. The papillomavirus E1 protein forms a DNA-dependent hexameric complex with ATPase and DNA helicase activities
51. Binding of the E1 and E2 proteins to the origin of replication of bovine papillomavirus
52. Bovine papillomavirus (BPV)-encoded E2 protein enhances binding of E1 protein to the BPV replication origin
53. Bovine papillomavirus (BPV) encoded E1 protein contains multiple activities required for BPV DNA replication
54. The E1 proteins
55. DNA binding domain of bovine papillomavirus type 1 E1 helicase: Structural and functional aspects
56. Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames
57. Identification of the origin of replication of bovine papillomavirus and characterization of the viral origin recognition factor E1
58. Large T-antigen double hexamers imaged at the simian virus origin of replication
59. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
60. The design and implementation of SnB version 2.0
61. A bovine pappilomavirus E1-related protein binds specifically to bovine papillomavirus DNA
62. Mapping of helicase and helicase substrate-binding domains on simian virus 40 large T antigen
63. Activation of BPV-1 replication in vitro by the transcription factor E2
64. The E1 protein of the papillomavirus BPV-1 is an ATP dependent DNA helicase