Immunopathogenesis of inflammatory bowel diseases;Zur Immunpathogenese der chronisch entzündlichen Darmerkrankungen

Chirurg

Volumn 71, Issue 1, 2000, Pages 30-40

  Neurath, M F ^a   Schurmann G ^b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b NONE

Author keywords

Crohn's disease; Cytokines; Mucosal immunology; Ulcerative colitis

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CELL ADHESION MOLECULE; CHEMOKINE; COMPLEMENTARY DNA; CYTOKINE; CYTOKINE RECEPTOR; IMMUNOLOGICAL ADJUVANT; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 12; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; AUTOIMMUNITY; COMPARATIVE STUDY; CROHN DISEASE; DRUG ANTAGONISM; ENTERITIS; GENE THERAPY; GENETIC PREDISPOSITION; HUMAN; IMMUNOLOGY; INTESTINE MUCOSA; MACROPHAGE; RECURRENT DISEASE; REVIEW; RISK FACTOR; T LYMPHOCYTE; ULCERATIVE COLITIS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; CELL ADHESION MOLECULES; CHEMOKINES; COLITIS, ULCERATIVE; CROHN DISEASE; CYTOKINES; DNA, ANTISENSE; GENE THERAPY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-10; INTERLEUKIN-11; INTERLEUKIN-12; INTESTINAL MUCOSA; MACROPHAGES; RECEPTORS, CYTOKINE; RECURRENCE; RISK FACTORS; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033631940     PISSN: 00094722     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001040050005     Document Type: Review

References (57)

1. Autschbach F, Braunstein J, Helmke B, Zuna I, et al (1998) In situ expression of interleukin-10 in noninflamed human gut and in inflammatory bowel disease. Am J Pathol 153: 121
2. Autschbach F, Qiao L, Schürmann G, Wallich R, et al (1995) Immunohistochemical reactivity of adhesion structure section mAb (subpanels 2-4) in peripheral and mucosa-associated lymphoid tissue and in Crohn's disease. Leukocyte typing V. Proc. of the fifth International Workshop and Conference, Boston 1993, p 1508
3. Autschbach F, Schürmann G, Qiao L, Merz H, et al (1995) Cytokine messenger RNA expression and proliferation status of intestinal mononuclear cells in noninflamed gut and Crohn's disease. Virchows Arch 426: 51
4. Boirivant M, Fuss IJ, Chu A, Strober W (1998) Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med 188: 1929
5. Braunstein J, Qiao L, Autschbach F, Schürmann G, Meuer S (1997) T cells of the human intestinal lamina propria are high producers of interleukin-10. Gut 41: 215
6. Breese E, Braegger CP, Corrigan CJ, Walker-Smith JA, MacDonald TT (1993) Interleukin-2 and interferon-gamma secreting T cells in normal and diseased human intestinal mucosa. Immunology 78: 127
7. Buhr H, Isbert C, Germer C (1998) Die operative Therapie des Morbus Crohn und Strategien bei voroperierten Patienten. Zentralbl Chir: 64
8. Casini-Raggi V, Kam L, Chong Y, Fiocchi C, et al (1995) Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation. J Immunol 154: 2434
9. Christ A, Stevens A, Koeppen H, Walsh S, et al (1998) An interleukin 12-related cytokine is up-regulated in ulcerative colitis but not in Crohn's disease. Gastroenterology 115: 307
10. D'Haens G, Geboes K, Peeters M, Baert F (1998) Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum. Gastroenterology 114: 262
11. Deventer S v, Elson C, Fedorak R (1997) Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Gastroenterology 113: 383
12. Donaldson R (1989) Crohn's disease. In: Sleisenger M, Fordtran J (eds) Gastrointestinal disease. Saunders, Philadelphia, p 1327
13. Duchmann R, Zeitz M (1999) Crohn's disease. In: Ogra P, Strober W (eds) Handbook of mucosal immunology. Academic Press, San Diego, p 1055
14. Dullemen H v, Deventer S v, Hommes D, Bijl H, et al (1995) Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 109: 129
15. Elson CO, Sartor RB, Tennyson GS, Riddell RH (1995) Experimental models of inflammatory bowel disease. Gastroenterology 109: 1344
16. Fuss I, Neurath MF, Boirivant M, Klein JS, et al (1996) Disparate CD4+ lamina propria (LP) lymphocyte secretion profiles in inflammatory bowel disease. J Immunol 157: 1261
17. Glickman R (1991) Inflammatory bowel disease. Ulcerative colitis and Crohn's disease. In: Wilson J (ed) Harrison's principles of internal medicine. McGraw-Hill, New York, p 1268
18. Greenwald B, James S (1993) Long-term HIV infection with Crohn's disease. Am J Gastroenterol 90: 167
19. Gross V, Andus, T, Caesar I, Roth M, Schölmerich J (1992) Evidence for continuous stimulation of IL-6 production in Crohn's disease. Gastroenterology 102: 514
20. Herfarth Ch, Heuschen G, Heuschen UA (1998) Die maligne Entartung im Verlauf der Colitis ulcerosa und ihre chirurgischen Implikationen. Chirurg 69: 1020
21. Heuschen G, Heuschen UA, Herfarth C (1998) Primär sklerosierende Cholangitis: Colitis ulcerosa-assoziierte Erkrankung mit chirurgischen Konsequenzen. Chirurg 69: 1028
22. Hofmann MA, Drury S, Fu C, Qu W, et al (1999) RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell 97: 889
23. Hugot J, Laurent-Puig P, Gowe-Rousseau C, Olson J, et al (1996) Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 379: 821
24. Hulten L, Ecker K (1998) Chirurgische Optionen bei Colitis ulcerosa. Zentralbl Chir 123: 368
25. Kornbluth A, Salomon P, Sachar DB (1995) Crohn's disease. In: Fordtran J, Sleisinger M (eds) Gastrointestinal disease. Pathophysiology, diagnosis, management. Saunders, Philadelphia, p 1270
26. Lopez-Cubero S, Sullivan K, McDonald G (1998) Course of Crohn's disease after allogenic marrow transplantation. Gastroenterology 114: 433
27. MacDermott R, Sanderson I, Reinecker H (1998) The central role of chemokines (chemotactic cytokines) in the immunopathogenesis of ulcerative colitis and Crohn's disease. Inflamm Bowel Dis 4: 54
28. Mizoguchi A, Mizoguchi E, Bhan AK (1999) The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice. Gastroenterology 116: 320
29. Mizoguchi A, Mizoguchi E, Chiba C, Bhan A (1996) Role of appendix in the development of inflammatory bowel disease in TCR-alpha mutant mice. J Exp Med 184: 707
30. Monteleone G, Biancone L, Marasco R, Morrone G, et al (1997) Interleukin-12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 112: 1169
31. Neurath MF, Becker C, Barbulescu K (1998) Role of NF-kappaB in immune and inflammatory responses in the gut. Gut 43: 856
32. Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W (1995) Antibodies to IL-12 abrogate established experimental colitis in mice. J Exp Med 182: 1280
33. Neurath MF, Pettersson S, Buschenfelde KHMz, Strober W (1996) Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappaB abrogates established experimental colitis in mice. Nature Med 2: 998
34. Picarella D, Hurlbut P, Rottman J, Shi X, et al (1997) Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells. J Immunol 158: 209
35. Pizarro TT, Michie MH, Bentz M, Woraratanadharm J, et al (1999) IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. J Immunol 162: 6829
36. Plevy S, Targan S, Yang H, Fernandez D, et al (1996) Tumor necrosis factor microsatellites define a Crohn's disease-associated haplotype on chromosome 6. Gastroenterology 110: 1053
37. Plevy SE, Landers CJ, Prehn J, Carramanzana NM, et al (1997) A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease. J Immunol 159: 6276
38. Podolsky D, Isselbacher K (1983) Composition of human colonic mucin. Selective alteration in inflammatory bowel disease. J Clin Invest 72: 142
39. Post S, Herfarth C, Bohm E, Timmermanns G, et al (1996) The impact of disease pattern, surgical management, and individual surgeons on the risk for relaparotomy for recurrent Crohn's disease. Ann Surg 223: 253
40. Poupon V, Cerf-Bensussan N (1999) Adhesion molecules on mucosal lymphocytes. In: Ogra PL, Bienenstock I, Strober W (eds). Mucosal Immunology, 2nd edn. Academic Press, San Diego, p 523
41. Powrie F, Leach MW, Mauze S, Menon S, et al (1994) Inhibition of Th1 responses prevents inflammatory bowel disease in seid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 2: 553
42. Rogler G, Andus T, Aschenbrenner E, Vogl D, et al (1997) Alterations of the phenotype of colonie macrophages in inflammatory bowel disease. Eur J Gastroenterol Hepatol 9: 893
43. Rogler G, Brand K, Vogl D, Page S, et al (1998) Nuclear factor kappa B is activated in macrophages and epitheleal cells of inflamed intestinal mucosa. Gastroenterology 115: 357
44. Schölmerich J (1998) Studien zur Rezidivprophylaxe des Morbus Crohn. Chirurg 69: 908
45. Schreiber S, Nikolaus S, Hampe J, Hamling J, et al (1999) Tumour necrosis factor a and interleukin 1 beta in relapse of Crohn's disease. Lancet 353: 459
46. Schürmann G (1997) Zelladhäsion. Molekulare Grundlagen und erste Aspekte für die Chirurgie. Chirurg 68: 477
47. Stack W, Mann S, Roy A, Heath P, et al (1997) Randomised controlled trial of CDP571 antibody to tumour necrosis factor-alpha in Crohn's disease. Lancet 349: 521
48. Stallmach A, Schäfer F, Hoffmann S, Weber S, et al (1998) Increased state of activation of CD4 positive T cells and elevated interferon-gamma production in pouchitis. Gut: 499
49. Strober W, Neurath MF (1995) Chapter 94. Immunological diseases of the gastrointestinal tract. In: Rich RR (ed) Clinical immunology. Mosby, St. Louis, p 1401
50. Strober W, Kelsall B, Fuss I, Marth T, et al (1997) Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation. Immunol Today 18: 61
51. Stumbles P, McWilliam A, Holt P (1999) Dendritic cells and mucosal macrophages. In: Ogra PL, Bienenstock I, Strober W (eds) Mucosal immunology, 2nd edn. Academic Press, San Diego, p 397
52. Sumer N, Palabiyikoglu M (1995) Induction of remission by interferon-alpha in patients with chronic active ulcerative colitis. Eur J Gastroenterol Hepatol 7: 597
53. Targan SR, Deem RL, Liu M, Wang S, Nel A (1995) Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway. J Immunol 154: 664
54. Targan SR, Hanauer SB, Deventer SJV, Mayer L, et al (1997) A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. N Engl J Med 337: 1029
55. Watanabe M, Ueno Y, Yajima T, Okamoto S, et al (1998) Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa. J Exp Med 187: 389
56. Wright N, Poulsom R, Stamp G, Pike C (1993) Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease. Gastroenterology 104: 12
57. Yacyshyn B, Bowen-Yacyshyn M, Jewell L, Tami J, et al (1998) A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease. Gastroenterology 114: 1133