The aromatic hydrocarbon receptor, transcription, and endocrine aspects of dioxin action

Vitamins and Hormones

Volumn 59, Issue , 2000, Pages 241-264

  Okino, Steven T ^a   Whitlock Jr , James P ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ARNT PROTEIN, HUMAN; ARNT PROTEIN, MOUSE; ARNT PROTEIN, RAT; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; DNA BINDING PROTEIN; HELIX LOOP HELIX PROTEIN; HYPOXIA INDUCIBLE FACTOR 1BETA; TERATOGENIC AGENT; TRANSCRIPTION FACTOR;

ANIMAL; DRUG EFFECT; ENHANCER REGION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; MOUSE; PHYSIOLOGY; POLLUTANT; PROMOTER REGION; PUBLIC HEALTH; RAT; REVIEW;

ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; CYTOCHROME P-450 CYP1A1; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); ENVIRONMENTAL POLLUTANTS; FEMALE; GENE EXPRESSION REGULATION; HELIX-LOOP-HELIX MOTIFS; HUMANS; MALE; MICE; PROMOTER REGIONS (GENETICS); PUBLIC HEALTH; RATS; RECEPTORS, ARYL HYDROCARBON; TERATOGENS; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION FACTORS;

EID: 0033628558     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0083-6729(00)59009-8     Document Type: Review

References (94)

1. B.D. Abbott Review of the interaction between TODD and glucocorticoids in embryonic palate Toxicology 105 1995 365 373
2. B.D. Abbott L.S. Birnbaum TCDD alters medial epithelial cell differentiation during palatogenesis Toxicol. Appl. Pharmacol. 99 1989 276 286
3. B.D. Abbott L.S. Birnbaum TCDD-induced altered expression of growth factors may have a role in producing cleft palate and enhancing the incidence of clefts after coadministration of retinoic acid and TODD Toxicol. Appl. Pharmacol. 106 1990 418 432
4. B.D. Abbott J.J. Diliberto L.S. Birnbaum 2,3,7,8-Tetrachlorodibenzo- p -dioxin alters embryonic palatal medial epithelial cell differentiation in vitro Toxicol. Appl. Pharmacol. 100 1989 119 131
5. B.D. Abbott G.A. Held C.R. Wood A.R. Buckalew J.G. Brown J. Schmid AhR, ARNT, and CYP1A1 mRNA quantitation in cultured human embryonic palates exposed to TODD and comparison with mouse palate in vivo and in culture Toxicol. Sci. 47 1999 62 75
6. B.D. Abbott J.E. Schmid J.G. Brown C.R. Wood R.D. White A.R. Buckalew G.A. Held RT-PCR quantification of AHR, ARNT, GR, and CYP1A1 mRNA in craniofacial tissues of embryonic mice exposed to 2,3,7,8-tetrachlorodibenzo- p -dioxin and hydrocortisone Toxicol. Sci. 47 1999 76 85
7. H.O. Adami L. Lipworth L. Titus-Ernstoff C.C. Hsieh A. Hanberg U. Ahlborg J. Baron D. Trichopoulos Organochlorine compounds and estrogen-related cancers in women Cancer Causes Control 6 1995 551 566
8. C.H. Bastomsky Enhanced thyroxine metabolism and high uptake goiters in rats after a single dose of 2,3,7,8-tetrachlorodibenzo- p -dioxin Endocrinology 101 1977 292 296
9. A. Bertazzi A.C. Pesatori D. Consonni A. Tironi M.T. Landi C. Zocchetti Cancer incidence in a population accidentally exposed to 2,3,7,8-tetrachlorodibenzo- p -dioxin Epidemiology 4 1993 398 406
10. K.M. Burbach A. Poland C.A. Bradfield Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor Proc. Natl. Acad. Sci. USA 89 1992 8185 8189
11. L.A. Carver C.A. Bradfield Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo J. Biol. Chem. 272 1997 11452 11456
12. L.A. Carver J.J. LaPres S. Jain E.E. Dunham C.A. Bradfield Characterization of the Ah receptor-associated protein, ARA9 J. Biol. Chem. 273 1998 33580 33587
13. J.D. Chen H. Li Coactivation and corepression in transcriptional regulation by steroid/nuclear hormone receptors Crit. Rev. Eukaryot. Gene Expr 8 1998 169 190
14. Y.H. Chen R.H. Tukey Protein kinase C modulates regulation of the CYP1A1 gene by the aryl hydrocarbon receptor J. Biol. Chem. 271 1996 26261 26266
15. A.H. Conney Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture Cancer Res. 42 1982 4875 4917
16. S.T. Crews Control of cell lineage-specific development and transcription by bHLH-PAS proteins Genes Dev. 12 1998 607 620
17. P.G. Curran L.J. DeGroot The effect of hepatic enzyme-inducing drugs on thyroid hormones and the thyroid gland Endocr. Rev. 12 1991 135 150
18. M.S. Denison S.D. Seidel W.J. Rogers M. Ziccardi G.M. Winter S. Health-Pagliuso Natural and synthetic ligands for the Ah receptor A. Puga K. Wallace Molecular Biology of the Toxic Response 1998 Taylor & Francis London 393 410
19. J. Dunlap Circadian rhythms: An end in the beginning Science 280 1998 1548 1549
20. M. Ema K. Sogawa N. Watanabe Y. Chujoh N. Matsushita O. Gotoh Y. Funae Y. Fujii-Kuriyama cDNA cloning and structure of mouse putative Ah receptor Biochem. Biophys. Res. Commun. 184 1992 246 253
21. J.W. Fahey Y. Zhang P. Talalay Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens Proc. Natl. Acad. Sci. USA 94 1997 10367 10372
22. P. Fernandez-Salguero T. Pineau D.M. Hilbert T. McPhail S.S. Lee S. Kimura D.W. Nebert S. Rudikoff J.M. Ward F.J. Gonzalez Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor Science 268 1995 722 726
23. P.M. Fernandez-Salguero D.M. Hilbert S. Rudikoff J.M. Ward F.J. Gonzalez Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo- p -dioxin-induced toxicity Toxicol. Appl. Pharmacol. 140 1996 173 179
24. B.E. Gillesby M. Stanostefano W. Porter S. Safe Z.F. Wu T.R. Zacharewski Identification of a motif within the 5′ regulatory region of pS2 which is responsible forAP-1 binding and TCDD-mediated suppression Biochemistry 36 1997 6080 6089
25. L.E. Gray Jr. J.S. Ostby In utero 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) alters reproductive morphology and function in female rat offspring Toxicol. Appl. Pharmacol. 133 1995 285 294
26. Y. Guo A.G. Hendrickx J.W. Overstreet J. Dieter D. Stewart A.F. Tarantal L. Laughlin B.L. Lasley Endocrine biomarkers of early fetal loss in cynomolgus macaques ( Macaca fascicularis ) following exposure to dioxin Biol. Reprod. 60 1999 707 713
27. G. Guroff J.W. Daly D.M. Jerina J. Renson B. Witkop S. Udenfriend Hydroxylation-induced migration: The NIH shift. Recent experiments reveal an unexpected and general result of enzymatic hydroxylation of aromatic compounds Science 157 1967 1524 1530
28. M.E. Hahn S.I. Karchner M.A. Shapiro S.A. Perera Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family Proc. Natl. Acad. Sci. USA 94 1997 13743 13748
29. O. Hankinson The aryl hydrocarbon receptor complex Annu. Rev. Pharmacol. Toxicol. 35 1995 307 340
30. I. Heimler R.G. Rawlins H. Owen R.J. Hutz Dioxin perturbs, in a doseand time-dependent fashion, steroid secretion, and induces apoptosis of human luteinized granulosa cells Endocrinology 139 1998 4373 4379
31. E.C. Hoffman H. Reyes F.F. Chu F. Sander L.H. Conley B.A. Brooks O. Hankinson Cloning of a factor required for activity of the Ah (dioxin) receptor Science 252 1991 954 958
32. K.W. Jones J.P. Whitlock Jr. Functional analysis of the transcriptional promoter for the CYP1A1 gene Mol. Cell. Biol. 10 1990 5098 5105
33. J.T. Kadonaga Eukaryotic transcription: An interlaced network of transcription factors and chromatin-modifying machines Cell 92 1998 307 313
34. I. Kharat F. Saatcioglu Antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo- p -dioxin are mediated by direct transcriptional interference with the liganded estrogen receptor. Cross-talk between aryl hydrocarbon- and estrogen-mediated signaling J. Biol. Chem. 271 1996 10533 10537
35. H.P. Ko S.T. Okino Q. Ma J.P. Whitlock Jr. Dioxin-induced CYP1A1 transcription in vivo : The aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure Mol. Cell. Biol. 16 1996 430 436
36. H.P. Ko S.T. Okino Q. Ma J.P. Whitlock Jr. Transactivation domains facilitate promoter occupancy for the dioxin-inducible CYP1A1 gene in vivo Mol. Cell. Biol. 17 1997 3497 3507
37. R.J. Kociba D.G. Keyes J.E. Beyer R.M. Carreon C.E. Wade D.A. Dittenber R.P. Kalnins L.E. Frauson C.N. Park S.D. Barnard R.A. Hummel C.G. Humiston Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo- p -dioxin in rats Toxicol. Appl. Pharmacol. 46 1978 279 303
38. M.C. Kohn C.H. Sewall G.W. Lucier C.J. Portier A mechanistic model of effects of dioxin on thyroid hormones in the rat Toxicol. Appl. Pharmacol. 136 1996 29 48
39. C. Koopman-Esseboom D.C. Morse N. Weisglas-Kuperus I.J. Lutkeschipholt C.G. Van der Paauw L.G. Tuinstra A. Brouwer P.J. Sauer Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants Pediatr Res. 36 1994 468 473
40. V. Krishnan W. Porter M. Santostefano X. Wang S. Safe Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8tetrachlorodibenzo- p -dioxin (TODD) in MCF-7 cells Mol. Cell. Biol. 15 1995 6710 6719
41. X. Li D.C. Johnson K.K. Rozman Effects of 2,3,7,8-tetrachlorodibenzo- p -dioxin (TODD) on estrous cyclicity and ovulation in female Sprague-Dawley rats Toxicol. Lett. 78 1995 219 222
42. W.P. Long M. Pray-Grant J.C. Tsai G.H. Perdew Protein kinase C activity is required for aryl hydrocarbon receptor pathway-mediated signal transduction Mol. Pharmacol. 53 1998 691 700
43. A. Lusska L. Wu J.P. Whitlock Jr. Superinduction of CYPlA1 transcription by cycloheximide. Role of the DNA binding site for the liganded Ah receptor J. Biol. Chem. 267 1992 15146 15151
44. Q. Ma J.P. Whitlock Jr. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo- p -dioxin J. Biol. Chem. 272 1997 8878 8884
45. T.A. Mably R.W. Moore R.E. Peterson In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo- p -dioxin. 1. Effects on androgenic status Toxicol. Appl. Pharmacol. 114 1992 97 107
46. N.J. MacLusky T.J. Brown S. Schantz B.W. Seo R.E. Peterson Hormonal interactions in the effects of halogenated aromatic hydrocarbons on the developing brain Toxicol. Ind. Health 14 1998 185 208
47. E. Maltepe J.V. Schmidt D. Baunoch C.A. Bradfield M.C. Simon Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT Nature 386 1997 403 407
48. B.K. Meyer M.G. Pray-Grant J.P. Vanden Heuvel G.H. Perdew Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity Mol. Cell. Biol. 18 1998 987 988
49. J. Mimura K. Yamashita K. Nakamura M. Morita T.N. Takagi K. Nakao M. Ema K. Sogawa M. Yasuda M. Katsuki Y. Fujii-Kuriyama Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo- p -dioxin (TODD) in mice lacking the Ah (dioxin) receptor Genes Cells 2 1997 645 654
50. J. Mimura M. Ema K. Sogawa Y. Fujii-Kuriyama Identification of a novel mechanism of regulation of Ah (dioxin) receptor function Genes Dev. 13 1999 20 25
51. R.W. Moore C.R. Jefcoate R.E. Peterson 2,3,7,8-Tetrachlorodibenzo- p -dioxin inhibits steroidogenesis in the rat testis by inhibiting the mobilization of cholesterol to cytochrome P450scc Toxicol. Appl. Pharmacol. 109 1991 85 97
52. J.E. Morgan J.P. Whitlock Jr. Transcription-dependent and transcription independent nucleosome disruption induced by dioxin Proc. Natl. Acad. Sci. USA 89 1992 11622 11626
53. J. Nagayama K. Okamura T. Iida H. Hirakawa T. Matsueda H. Tsuji M. Hasegawa K. Sato H.Y. Ma T. Yanagawa H. Igarashi J. Fukushige T. Watanabe Postnatal exposure to chlorinated dioxins and related chemicals on thyroid hormone status in Japanese breast-fed infants Chemosphere 37 1998 1789 1793
54. D.W Nebert The Ah locus: Genetic differences in toxicity, cancer, mutation, and birth defects Crit. Rev. Toxicol. 20 1989 153 174
55. L.A. Neuhold Y. Shirayoshi K. Ozato J.E. Jones D.W. Nebert Regulation of mouse CYP1A1 gene expression by dioxin: Requirement of two cis-acting elements during induction Mol. Cell. Biol. 9 1989 2378 2386
56. S.T. Okino J.P. Whitlock Jr. Dioxin induces localized, graded changes in chromatin structure: Implications for Cyp1A1 gene transcription Mol. Cell. Biol. 15 1995 3714 3721
57. J.M. Peters M.G. Narotsky G. Elizondo P.M. Fernandez-Salguero F.J. Gonzalez B.D. Abbott Amelioration of TODD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice Toxicol. Sci. 47 1999 86 92
58. R.E. Peterson H.M. Theobald G.L. Kimmel Developmental and reproductive toxicity of dioxins and related compounds: Cross-species comparisons Crit. Rev. Toxicol. 23 1993 283 335
59. D.H. Phillips Fifty years of benzo( a )pyrene Nature 303 1983 468 472
60. A. Poland J.C. Knutson 2,3,7,8-Tetrachlorodibenzo- p -dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity Annu. Rev. Pharmacol. Toxicol. 22 1982 517 554
61. J.A. Powell-Coffman C.A. Bradfield W.B. Wood Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner, the aryl hydrocarbon receptor nuclear translocator Proc. Natl. Acad. Sci. USA 95 1998 2844 2849
62. R.M. Pratt L. Dencker V.M. Diewert 2,3,7,8-Tetrachlorodibenzo- p -dioxin-induced cleft palate in the mouse: Evidence for alterations in palatal shelf fusion Teratog. Carcinog. Mutagen 4 1984 427 436
63. W.B. Pratt The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase Annu. Rev. Pharmacol. Toxicol. 37 1997 297 326
64. M. Ptashne A. Gann Transcriptional activation by recruitment Nature 386 1997 569 577
65. H. Reyes S. Reisz-Porszasz O. Hankinson Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor Science 256 1992 1193 1195
66. M.S. Ricci D.G. Toscano C.J. Mattingly W.A. Toscano Jr. Estrogen receptor reduces CYP1A1 induction in cultured human endometrial cells J. Biol. Chem. 274 1999 3430 3438
67. J.C. Rowlands J.A. Gustafsson Aryl hydrocarbon receptor-mediated signal transduction Crit. Rev. Toxicol. 27 1997 109 134
68. S. Safe F. Wang W. Porter R. Duan A. McDougal Ah receptor agonists as endocrine disruptors: Antiestrogenic activity and mechanisms Toxicol. Lett. 102 1998 343 347
69. S.H. Safe Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo- p -dioxin and related compounds Pharmacol. Ther. 67 1995 247 281
70. J.V. Schmidt C.A. Bradfield Ah receptor signaling pathways Annu. Rev. Cell. Dev. Biol. 12 1996 55 89
71. J.V. Schmidt G.H. Su J.K. Reddy M.C. Simon C.A. Bradfield Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development Proc. Natl. Acad. Sci. USA 93 1996 6731 6736
72. H. Shibata T.E. Spencer S.A. Onate G. Jenster S.Y. Tsai M.J. Tsai B.W. O'Malley Role of co-activators and co-repressors in the mechanism of steroid/ thyroid receptor action Recent Prog. Horm. Res. 52 1997 141 164
73. H. Shibata T.E. Spencer S.A. Onate G. Jenster S.Y. Tsai M.J. Tsai B.W. O'Malley Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action discussion Recent Prog. Horm. Res. 52 1997 164 165
74. J.B. Silkworth D.S. Cutler L. Antrim D. Houston C. Tumasonis L.S. Kaminsky Teratology of 2,3,7,8-tetrachlorodibenzo- p -dioxin in a complex environmental mixture from the Love Canal Fundam. Appl. Toxicol. 13 1989 1 15
75. K. Sogawa Y. Fujii-Kuriyama Ah receptor, a novel ligand-activated transcription factor J. Biochem. (Tokyo) 122 1997 1075 1079
76. D.C. Spink D.W.D. Lincoln H.W. Dickerman J.F. Gierthy 2,3,7,8-Tetrachlorodibenzo- p -dioxin causes an extensive alteration of 17 β-estradiol metabolism in MCF-7 breast tumor cells Proc. Natl. Acad. Sci. USA 87 1990 6917 6921
77. D.C. Spink C.L. Hayes N.R. Young M. Christou T.R. Sutter C.R. Jefcoate J.F. Gierthy The effects of 2,3,7,8-tetrachlorodibenzo- p -dioxin on estrogen metabolism in MCF-7 breast cancer cells: Evidence for induction of a novel 17 β-estradiol 4-hydroxylase J. Steroid Biochem. Mol. Biol. 51 1994 251 258
78. K. Struhl Histone acetylation and transcriptional regulatory mechanisms Genes Dev. 12 1998 599 606
79. Y. Takahashi K. Nakayama S. Itoh Y. Fujii-Kuriyama T. Kamataki Inhibition of the transcription of CYPIA1 gene by the upstream stimulatory factor 1 in rabbits. Competitive binding of USF1 with AhR-Arnt complex J. Biol. Chem. 272 1997 30025 30031
80. Y. Tian S. Ke T. Thomas R.J. Meeker M.A. Gallo Transcriptional suppression of estrogen receptor gene expression by 2,3,7,8-tetrachlorodibenzo- p -dioxin (TODD) J. Steroid Biochem. Mol. Biol. 67 1998 17 24
81. A.J. Watson K.I. Weir-Brown R.M. Bannister F.F. Chu S. Reisz-Porszasz Y. Fujii-Kuriyama K. Sogawa O. Hankinson Mechanism of action of a repressor of dioxin-dependent induction of Cyplal gene transcription Mol. Cell. Biol. 12 1992 2115 2123
82. R.H. Wenger M. Gassmann Oxygen(es) and the hypoxia-inducible factor-1 Biol. Chem. 378 1997 609 616
83. J.P. Whitlock Jr. Mechanistic aspects of dioxin action Chem. Res. Toxicol. 6 1993 754 763
84. J.P. Whitlock Jr. Induction of cytochrome P4501A1 Annu. Rev. Pharmacol. Toxicol. 39 1999 103 125
85. J.P. Whitlock Jr. S.T. Okino L. Dong H.P. Ko R. Clarke-Katzenberg Q. Ma H. Li Chytochromes P450 5: Induction of cytochrome P4501A1: A model for analyzing mammalian gene transcription FASEB J. 10 1996 809 818
86. J. Widom Structure, dynamics, and function of chromatin in vitro Annu. Rev. Biophys. Biomol. Struct. 27 1998 285 327
87. J.J. Willey B.R. Stripp R.B. Baggs T.A. Gasiewicz Aryl hydrocarbon receptor activation in genital tubercle, palate, and other embryonic tissues in 2,3,7,8tetrachlorodibenzo- p -dioxin-responsive lacZ mice Toxicol. Appl. Pharmacol. 151 1998 33 44
88. C. Wu Chromatin remodeling and the control of gene expression J. Biol. Chem. 272 1997 28171 28174
89. L. Wu J.P. Whitlock Jr. Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo Proc. Natl. Acad. Sci. USA 89 1992 4811 4815
90. L. Wu J.P. Whitlock Jr. Mechanism of dioxin action: Receptor-enhancer interactions in intact cells Nucleic Acids Res. 21 1993 119 125
91. A. Yanagida K. Sogawa K.I. Yasumoto Y. Fujii-Kuriyama A novel cis-acting DNA element required for a high level of inducible expression of the rat P-450c gene Mol. Cell. Biol. 10 1990 1470 1475
92. T. Zacharewski M. Harris S. Safe Evidence for the mechanism of action of the 2,3,7,8-tetrachlorodibenzo- p -dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant mouse Hepa 1c1c7 cells Biochem. Pharmacol. 41 1991 1931 1939
93. T.R. Zacharewski K.L. Bondy P. McDonell Z.F. Wu Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo- p -dioxin on 17β-estradiol-induced pS2 expression Cancer Res. 54 1994 2707 2713
94. E. Zelzer Y. Levy C. Kahana B.Z. Shilo M. Rubinstein B. Cohen Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-lalpha/ARNT EMBO J. 17 1998 5085 5094