Over-expression of p27(kip1) induces growth arrest and apoptosis mediated by changes of pRB expression in lung cancer cell lines

International Journal of Cancer

Volumn 88, Issue 3, 2000, Pages 377-383

  Naruse, Ichiro ^a   Hoshino, Hideki ^a   Dobashi, Kunio ^a   Minato, Koichi ^a   Saito, Ryusei ^a   Mori, Masatomo ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P27; VIRUS VECTOR; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MICROTUBULE ASSOCIATED PROTEIN; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; HUMAN; HUMAN CELL; LUNG CANCER; PRIORITY JOURNAL; CELL CULTURE; CELL CYCLE; CELL DIVISION; FLOW CYTOMETRY; GENETIC TRANSFECTION; LUNG TUMOR; NICK END LABELING; PATHOLOGY; PHYSIOLOGY; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FLOW CYTOMETRY; HUMANS; IN SITU NICK-END LABELING; LUNG NEOPLASMS; MICROTUBULE-ASSOCIATED PROTEINS; RETINOBLASTOMA PROTEIN; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0033623439     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20001101)88:3<377::AID-IJC9>3.0.CO;2-M     Document Type: Article

References (36)

1. Cleavage of retinoblastoma protein during apoptosis: An interferon 1 beta-converting enzyme-like protease candidate
2. Positive correlation between p27(kip1) expression and progression of human esophageal squamous cell carcinoma
3. Retinoblastoma protein inhibits IFN-gamma induced apoptosis
4. Vectors in cancer therapy: How will they deliver?
5. Decreased levels of the cell cycle inhibitor p27(kip1) protein: Prognostic implications in primary breast cancer
6. Reduced expression of cell cycle inhibitor p27(kip1) in non-small cell lung carcinoma: A prognostic factor independent of ras
7. Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic over-expression of the cyclin-dependent kinase inhibitor p27(Kip1)
8. 1 checkpoint control
9. In vivo gene therapy with p53 or p21 and adenovirus for prostate cancer
10. Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer
11. The retinoblastoma gene product inhibits TGF-β1 induced apoptosis in primary rat hepatocytes and HuH-7 hepatoma cells
12. Mutation analysis of the human cyclin-dependent kinase inhibitor p27(kip1) in primary breast carcinomas
13. Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene
14. p21 (Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells
15. Independent prognostic role of p16 expression in lung cancer
16. Inhibition of apoptosis by the retinoblastoma gene product
17. Interleukin-2 gene transduction into freshly isolated lung adenocarcinoma cells with adenoviral vectors
18. Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
19. The cyclin-dependent kinase inhibitor p27 as a prognostic factor in advanced non-small cell lung cancer: Its immunohistochemical evaluation using biopsy specimens
20. Correlation between methylation status of the p16/CDKN2 gene and the expression of p16 and pRb proteins in primary non-small cell lung cancers
21. Promoting apoptosis: A novel activity associated with the cyclin-dependent kinase inhibitor p27
22. Molecular analysis of the cyclin-dependent kinase inhibitor gene p27(kip1) in human malignancies
23. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
24. p27(kip1), a cyclin-dependent kinase inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
25. Cloning of p27(kip1), a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
26. p27(kip1): Chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors
27. Expression of cell cycle regulators p27(kip1) and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
28. Modification of tumor suppressor gene expression and induction of apoptosis in non-small cell lung cancer (NSCLC) with an adenovirus vector expressing wild-type p53 and cisplatin
29. Adenovirally transferred p16(ink4)/CDKN2 and p53 genes cooperative to induce apoptotic tumor cell death
30. Comparison of effectiveness of adenovirus vectors expressing cyclin kinase inhibitor p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(kip1) in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity
31. Adenovirus-mediated p53 gene transfer in advanced non-small cell lung cancer
32. Disruption of the RB pathway and cell-proliferative activity in non-small-cell lung cancers
33. Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma
34. 1 cyclin-Cdk protein kinase activity, is related to p21
35. Prognostic significance of p53 codon 72 polymorphism in lung carcinomas
36. Expression of p16 and lack of pRb in primary small cell lung cancer