Inhibition of aflatoxin M1 production by bovine hepatocytes after intervention with oltipraz

Veterinary Quarterly

Volumn 22, Issue 1, 2000, Pages 30-35

  Kuilman, M E M ^b   Maas, R F M ^a   Woutersen van Nijnanten, F M A ^a   Fink Gremmels, J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Aflatoxin B1; Aflatoxin M1; Bovine metabolism; Hepatocytes; Oltipraz

Indexed keywords

AFLATOXIN M1; OLTIPRAZ; ANTINEOPLASTIC AGENT; CYTOCHROME P450; PYRAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; CATTLE; CATTLE DISEASE; DAIRY INDUSTRY; LIVER METABOLISM; NONHUMAN; ANIMAL; ANIMAL FOOD; BIOSYNTHESIS; CHEMISTRY; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; FOOD CONTAMINATION; LIVER; METABOLISM; MILK;

AFLATOXIN M1; ANIMAL FEED; ANIMALS; ANTICARCINOGENIC AGENTS; CATTLE; CELL CULTURE TECHNIQUES; CYTOCHROME P-450 ENZYME SYSTEM; FOOD CONTAMINATION; LIVER; MILK; PYRAZINES;

EID: 0033621918     PISSN: 01652176     EISSN: 18755941     Source Type: Journal    
DOI: 10.1080/01652176.2000.9695020     Document Type: Article

References (39)

1. Auerbach H, Maas RFM, Op den Camp HJM, Pol A, and Fink-Gremmels J. Biodegradation of aflatoxin Bi by bovine rumen microorganisms in vitro and its effects on rumen fermentation. Rev Med Vet 1998; 6: 573 (Abstr).
2. Ball R W, and Coulombe RA. Comparative biotransformation of aflatoxin B1 in mammalian airway epithelium. Carcinogenesis 1991; 12: 305-10.
3. Benson AB. Oltipraz: a laboratory and clinical review. J Cell Biochem 1993; 17F(Suppl.): 278-91.
4. Bhatnagar D, Lillehoj EB, and Bennett JW. Biological detoxification of mycotoxins in Mycotoxins in Animal Foods 1991; Smith JE and Henderson RS, ed CRC Press, Boston.
5. Bieder A, Decouvelaere B, Gaillard C, Depaire H, Heusse D, Ledoux C, Lemar M, Le Roy J P, Raynaud L, Snozzi C, and Gregoire J. Comparison of the metabolism of oltipraz in the mouse, rat and monkey and in man. Arzneim-Forsch/Drug-Res 1983; 33 (II): 1289-97.
6. Buetler TM, Bammler TK, Hayes JD, and Eaton DL. Oltipraz mediated changes in aflatoxin Bi biotransformation in rat liver: implication for chemoprevention. Cancer Res 1996; 56: 2306-13.
7. Butler MA, Iwasaki M, Guengerich FP, and Kadlubar FK. Human cytochrome P450pa (P4501A2), the phenacetin 0-deethylase is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Proc Natl Acad Sci USA 1989; 86: 7696-700.
8. Cleveland RE, Bhatnagar D, and Cotty PJ. Control of biosynthesis in strains of Aspergillus flavus in Perspectives on Aflatoxins in Field Crops and Animal Food Products in the United States (ARS-83). National Technical Information Services 1990; Springfield, Vi.
9. Cole RJ, and Cottey PJ. Biocontrol of aflatoxin production by using biocompetitive agents in Perspectives on Aflatoxins in Field Crops and Animal Food Products in the United States (ARS-83). National Technical Information Services 1990; Springfield, Vi.
10. Denizat F, and Lang R. Rapid colorometric assay for cell growth and survival. J Immun Meth 1986; 89: 271-7.
11. Egner PA, Kensler TW, Prestera T, Talalay P, Libby AH, Joyner HH, and Curphey TJ. Regulation of phase 2 enzyme induction by oltipraz and other dithiolthiones. Carcinogenesis 1994; 15: 177-81.
12. Fink-Gremmels J, and Miert ASJPAM van. Species differences in biotransformation: conventional models in unconventional animal species. Exp Toxic Pathol (Suppl. II) 1996; 48: 120-7.
13. Forrester LM, Neal GE, Judah DJ, Glancey MJ, and Wolf CR. Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B metabolism in human liver. Proc Natl Acad Sci USA 1990; 87: 8306-10.
14. Frayssinet C, and Frayssinet-LaFarge C. Effect of ammoniation on the carcinogenicity of aflatoxin-contaminated groundnut oil cakes: Longterm feeding study in the rat. Food Add Cont 1990; 7: 63-8.
15. Fremy JM, and Quillardet P. The ‘carry-over’ of aflatoxin into milk of cows fed ammoniated rations: Use of an HPLC method and a genotoxicity test for determining milk safety. Food Addit Cont 1985; 2: 201-7.
16. Habig WH, Pabst MJ, and Jakoby WB. Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 249: 7130-9.
17. Hapke HJ. Toxicologische Aspekte der Ernahrung. Pages 107-185 in Ernahrungsbericht 1996. Deutschen Gesellschaft für Ernährung eV: Frankfurt am Main, Germany.
18. Imaoka S, Ikemoto S, Shimada T, and Funs. Mutagenic activation of aflatoxin B1 by pulmonary, renal and hepatic cytochrome P450s from rats. Mut Res 1992; 269: 231-6.
19. Jacobson LP, Zhang BC, Zhu YR, Wang JB, Wu Y, Zhang QN, Yu LY, Qian GS, Kuang SY, and Li YF. Oltipraz chemoprevention trial in Qidong, People’s Republic of China: study design and clinical outcomes. Cancer Epidemiol Biomarkers Prey 1997; 6: 257-65.
20. Klaveren JD van. Results residue monitoring in The Netherlands: Program for the Quality of Agricultural Products. State Institute for Quality Control of Agricultural Products 1998; Wageningen, The Netherlands.
21. Klooster GAE van ‘t, Woutersen-van Nijnanten FMA, Klein WR, Blaauboer BJ, Noordhoek J, and Miert ASJPAM van. Effects of various medium formulations and attachment substrata on the performance of cultured ruminant hepatocytes in biotransformation studies. Xenobiotica 1992; 22: 523-34.
22. Kuilman MEM, Maas RFM, Judah DJ, and Fink-Gremmels J. Bovine hepatic biotransformation of aflatoxin B,. J Agric Food Chem 1998; 46: 2707-13.
23. Langoudt S, Coles B, Morel F, Becquemont L, Beaune P, Guengerich FP, Ketterer B and Guillouzo A. Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture. Cancer Res 1995; 55: 5574-9.
24. LangouEt S, Mahéo K, Berthou F, Morel F, Lagadic-Gossman D, Glaise D, Coles B, Ketterer B, and Guillouzo A. Effects of administration of the chemoprotective agent oltipraz on CYP1A and CYP2B in rat liver and rat hepatocytes in culture. Carcinogenesis 1997; 18: 1343-9.
25. Larsson P, Petterson H, and Tjälve H. Metabolism of aflatoxin B1 in the bovine olfactory mucosa. Carcinogenesis 1989; 10: 1113-8.
26. Larsson P, and Tjälve H. Bioactivation of aflatoxin B1 in the nasal and tracheal mucosa of swine. J Anim Sci 1996; 74:1672-80.
27. Liu L, and Massey TE. Bioactivation of aflatoxin B1 by lipoxygenases, prostagland in H synthase and cytochrome P450 monooxygenase in guinea-pig tissues. Carcinogenesis 1992; 13: 533-9.
28. Lowry OH, Rosebourgh NJ, Farr AL, and Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75.
29. Mann GE, Gardner HK, Booth AN, and Grundmann MR. Aflatoxin inactivation. Chemical and biological properties of ammonia and methylamine treated cottonseed meal. J Agric Food Chem 1971; 19: 1155-8.
30. Nakazato M, Morozumi S, Saito K, Fujinuma K, Nishima T, and Kasai N. Interconversion of aflatoxin B1 and aflatoxicol by several fungi. Appl Environ Microbiol 1990; 56: 1456-70.
31. Park DL, and Rua SM. Biological evaluation of aflatoxins and metabolites in animal tissues. Drug MetabolRev 1990; 22: 871-90.
32. Philips TD, Clement BA, and Park DL. Approaches to reduction of aflatoxins in foods and feeds. In: The Toxicology of Aflatoxins, Human Health, Veterinary and Agricultural Significance. DL Eaton and JD Groopman (eds) Acad Press, San Diego, CA 1994; pp 383-406.
33. Redegeld FAM, Hofman GA, and Noordhoek J. Conjugative clearance of 1-naphthol and dispostion of its glucuronide and sulphate conjugates in the isolated perfused rat kidney. J Pharmacol Ther 1988; 244: 264-7.
34. Relling MV, Aoyama T, Gonzales FJ, and Meyer UA. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. J Pharmacol Exp Ther 1990; 252: 442-7.
35. Scholl P, Musser SM, Kensler TW, and Groopman JD. Inhibition of aflatoxin M1 excretion in rat urine during dietary intervention with oltipraz. Carcinogenesis 1996; 17: 1385-8.
36. Trucksess MW, Richard JL, Stoloff L, McDonald JS, and Brumley WC. Absorption and distribution patterns of aflatoxicol and aflatoxins B1 and Mi in blood and milk of cows given aflatoxin B1. Am J Vet Res 1983; 44: 1753-6.
37. Wei CI, and Hsieh DPH. Characterization of water-soluble glucuronide and sulphate conjugates of aflatoxin B1. 2. Studies in primary cultures of rat hepatocytes. Food Chem Toxicol 1985; 9: 821-5.
38. Wortelboer HM, de Kruif CA, Iersel AAJ van, Falke HE, Noordhoek J, and Blaauboer BJ. The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers. Biochem Pharmacol 1990; 40: 2525-34.
39. Yu JH, Butch RAE, Fernandes M, Keller NP, Leonard TJ, and Adams TH. Conservation of structure and function of the aflatoxin regulatory gene afIR from Aspergillus nidulans and A. flavus Curr Genet 1996; 29: 549-55.