Bioactivation of Aflatoxin B1 in the Nasal and Tracheal Mucosa in Swine

Journal of Animal Science

Volumn 74, Issue 7, 1996, Pages 1672-1680

  Larsson, Pia ^a   Tjälve, Hans ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Aflatoxins; Conjunctiva; Glutathione Transferase; Melanins; Pigs

Indexed keywords

AFLATOXIN B1; DNA; GLUTATHIONE; TRITIUM;

ANIMAL; ANIMAL DISEASE; ARTICLE; AUTORADIOGRAPHY; BIOTRANSFORMATION; CHEMISTRY; CONJUNCTIVA; FEMALE; LIVER; METABOLISM; MUCOSA; NOSE MUCOSA; OLFACTORY EPITHELIUM; PHYSIOLOGY; SWINE; TRACHEA;

AFLATOXIN B1; ANIMALS; AUTORADIOGRAPHY; BIOTRANSFORMATION; CONJUNCTIVA; DNA; FEMALE; GLUTATHIONE; LIVER; MUCOUS MEMBRANE; NASAL MUCOSA; OLFACTORY MUCOSA; SWINE; TRACHEA; TRITIUM;

EID: 0030184740     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/1996.7471672x     Document Type: Article

References (37)

1. 1. Proc. Natl. Acad. Sci. USA 87:4790.
2. Burg, W. R., and O. L. Shotwell. 1984. Aflatoxin levels in air-borne dust generated from contaminated corn during harvest and at an elevator in 1980. J. Assoc. Off. Anal. Chem. 67:309.
3. Busby, W. F., Jr., and G. N. Wogan. 1984. Aflatoxins. In: C. E. Searle (Ed.) Chemical Carcinogens. ACS Monograph 182, Vol. 22:945. American Chemical Society, Washington, DC.
4. Cook, W. O., W. G. Van Alstine, and G. D. Osweiler. 1989. Aflatoxicosis in Iowa swine: Eight cases (1983-1985). J. Am. Vet. Med. Assoc. 194(4):554.
5. 1 and comparison to CYP1A2 and CYP2A4. Carcinogenesis 12(2):355.
6. Dahl, A. R., and W. M. Hadley. 1991. Nasal cavity enzymes involved in xenobiotic metabolism: Effects on the toxicity of inhalants. CRC Crit. Rev. Toxicol. 21:345.
7. Dickens, F., H.E.H. Jones, and H. B. Waynforth. 1966. Oral subcutaneous and intratracheal administration of carcinogenic lactones and related substances: The intratracheal administration of cigarette tar in the rat. Br. J. Cancer 20:134.
8. Diekman, M. A., and M. L. Green. 1992. Mycotoxins and reproduction in domestic livestock. J. Anim. Sci. 70:1615.
9. 1: Patterns of DNA adduct formation, removal, and excretion in relation to carcinogenesis. Drug Metab. Rev. 13:581.
10. Eaton, D. L., and E. P. Gallhagher. 1994. Mechanisms of aflatoxin carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 34:153.
11. Larsson, B. S. 1993. Interaction between chemicals and melanin. Pigm. Cell Res. 6:127.
12. 1 in sheep. Carcinogenesis (Oxf.) 15:947.
13. 1 in mice: Formation and retention of tissue bound metabolites in nasal glands. Pharmacol. Toxicol. 67:162.
14. 1 to melanin. Food Chem. Toxicol. 26:579.
15. 1 in the bovine olfactory mucosa. Carcinogenesis (Oxf.) 10:1113.
16. 1 metabolites in extrahepatic tissues in fetal and infant mice and in adult mice with depleted glutathione levels. Cancer Res. 52:1267.
17. 1 in the marmoset monkey (Callithrix jacchus). Carcinogenesis (Oxf.) 14:1.
18. 1 in fetal, infant and adult rats. Chem.-Biol. Interact. 94:1.
19. Lewis, G., L. M. Markson, and R. Allcroft. 1967. The effect of feeding toxic groundnut meal to sheep over a period of five years. Vet. Rec. 80:312.
20. 1 to DNA by glutathione S-transferase. Cancer Lett. 9:143.
21. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265.
22. Moulton, J. E. 1990. Tumors of the respiratory system. In: J. E. Moulton (Ed.) Tumors in Domestic Animals (3rd Ed.). p 308. University of California Press, London.
23. Newberne, P. M., and W. H. Butler. 1969. Acute and chronic effects of aflatoxin on the liver of domestic and laboratory animals: A review. Cancer Res. 29:236.
24. Plopper, C. G., D. L. Cranz, C. Kemp, C. J. Serabjit-Singh, and R. M. Philpot. 1987. Immunohistochemical demonstration of cytochrome P450 monooxygenase in Clara cells throughout the tracheobronchial airways of the rabbit. Exp. Lung Res. 13:59.
25. Popp, J. A. 1990. Tumors of the liver, gall bladder and pancreas. In: J. E. Moulton (Ed.) Tumors in Domestic Animals (3rd Ed.). p 436. University of California Press, London.
26. Pulley, L. T., and A. A. Stannard. 1990. Tumors of the skin and soft tissues. In: J. E. Moulton (Ed.) Tumors in Domestic Animals (3rd Ed.). p 23. University of California Press, London.
27. 1. Toxicol. Appl. Pharmacol. 105:351.
28. Rajan, A., C. G. Sivadas, M. Krishnan Nair, and K. I. Maryamma. 1972. Incidence and pathology of tumours of the paranasal sinuses in domestic animals. Kerala J. Vet. Sci. 3:89.
29. Reed, C. J., E. A. Lock, and F. De Matteis. 1986. NADPH: Cytochrome P-450 reductase in olfactory epithelium. Relevance to cytochrome P-450-dependent reactions. Biochem. J. 240:585.
30. Sörenson, W. G., J. P. Simpson, M. J. Peach, III, T. D. Thedell, and S. A. Olenchock. 1981. Aflatoxin in respirable corn dust particles. J. Toxicol. Environ. Health 7:669.
31. Sreekumaran, T., and A. Rajan. 1983. Epidemiology of ethmoid carcinoma in bovines. Indian J. Cancer 20:5.
32. 1 in the bovine olfactory mucosa: DNA binding, mutagenicity and induction of sister chromatid exchanges. Carcinogenesis 13:1345.
33. Ullberg, S., B. Larsson, and H. Tjälve. 1982. Autoradiography. In: H. J. Glenn (Ed.) Biologic Application of Radiotracers. p 56. CRC Press, Boca Raton, FL.
34. van Heugten, E., J. W. Spears, M. T. Coffey, E. B. Kegley, and M. A. Qureshi. 1994. The effect of methionine and aflatoxin on immune function in weanling pigs. J. Anim. Sci. 72:658.
35. 1 in mammalian airway epithelium. Cancer Res. 50:2493.
36. Yonemichi, H., T. Ohgi, Y. Fujimoto, K. Okada, M. Onuma, and T. Mikami. 1978. Intranasal tumor of the ethmoid olfactory mucosa in sheep. Am. J. Vet. Res. 39:1599.
37. 1 binding to single- and double-stranded DNAs. Carcinogenesis 11:475.