Antiviral activity of inhibitors of pyrimidine de-novo biosynthesis

Antiviral Chemistry and Chemotherapy

Volumn 7, Issue 1, 1996, Pages 7-13

  Wachsman, M ^a   Hamzeh, F M ^a   Assadi, N B ^a   Lietman, P S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acivicin; Antiviral; Azaserine; Brequinar; Cytomegalovirus; Deoxynucleotide metabolism

Indexed keywords

2 (3,3 DICHLOROALLYL) 3 HYDROXY 1,4 NAPHTHOQUINONE; 6 DIAZO 5 OXO 1 NORLEUCINE; ACIVICIN; ANTIVIRUS AGENT; AZASERINE; BREQUINAR; DEOXYNUCLEOSIDE TRIPHOSPHATE; GANCICLOVIR; PHOSPHORACETYL ASPARTIC ACID; PIRAZOFURIN; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; CYTOTOXICITY; DNA SYNTHESIS; HERPES SIMPLEX VIRUS 1; HOST CELL; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; LUNG FIBROBLAST; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS; VIRUS REPLICATION;

EID: 0030034947     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632029600700102     Document Type: Article

References (28)

1. Ahluwalia, G.S., Grem, J.L., Hao, Z., and Cooney, D.A. (1990) Metabolism and action of amino acid analog anti-cancer agents. Pharmaco Ther 46: 243-271.
2. Albrecht, T., Nachtigal, M., St. Jeor, S.C., and Rapp, F. (1976) Induction of cellular DNA synthesis and increased mitotic activity in syrian hamster embryo cells abortively infected with human cytomegalovirus. J Gen Virol 30: 167-177.
3. Biron, K.K., Fyfe, J.A., Stanat, S.C., Leslie, L.K., Sorrell, J.B., Lambe, C U., and Coen, D.M. (1986) A human cytomegalovirus mutant resistant to the nucleoside analog 9-{[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl}guanine (BW B759U) induces reduced levels of BW B759U triphosphate. PNAS 83: 8769-8773.
4. Boldogh, I., Abubakar, S., Deng, C.Z., and Albrecht, T. (1991) Transcriptional activation of cellular oncogenes fos, jun, and myc by human cytomegalovirus. J Virol 65: 1568-1571.
5. Bray, G. and Brent, T.P. (1971) Deoxyribonucleoside 5′-triphosphate pool fluctuations during the mammalian cell cycle. Biochim Biophys Acta 269: 184-191.
6. Chee, M.S., Bankier, A.T., Beck, S., Bohni, R., Brown, C.M., Cemy, R., Horsnell, T., Hutchison, C.A. 3d, Kouzarides, T., Martignetti, J.A., Preddie, E., Satchell, S.C.W., Tomlinson, P., Weston, K.M., and Barrell, B.G. (1990) Analysis of the protein coding content of the sequence of human cytomegalovirus strain AD168. Curr Top Microbiol Immunol 154: 125-170.
7. Estes, J.E., and Huang, E.-S. (1977) Stimulation of cellular thymidine kinases by human cytomegalovirus. J Virol 24: 13-21.
8. Gentry, G.A. (1992) Viral thymidine kinases and their relatives. Pharm Ther 54: 319-355.
9. Gönczöl, E., and Plotkin, S.A. (1984) Cells infected with human cytomegalovirus release a factor(s) that stimulates cell DNA synthesis. J Gen Virol 65: 1833-1837.
10. Grem, J.L., King, S. A., O'Dwyer, P. J., and Leyland-Jones, B. (1988) Biochemistry and clinical activity of N-(Phosphonacetyl)-L-aspartate: A review. Cancer Res 48: 4441-4454.
11. Hamzeh, F.M., and Lietman, P.S. (1991) Intranuclear accumulation of subgenomic noninfectious human cytomegalovirus DNA in infected cells in the presence of ganciclovir. Antimicrob Agents Chemo 35: 1818-1823.
12. Hamzeh, F.M., Lietman, P.S., Gibson, W., and Hayward, G.S. (1990) Identification of the lytic origin of DNA replication in human cytomegalovirus by a novel approach utilizing ganciclovir-induced chain termination. J Virol 64: 6184-6195.
13. Hamzeh, F.M., Spector, T., and Lietman, P.S. (1993) 2-Acetylpyridine 5-[(dimethylamino)-thiocarbonyl] thiocarbonohydrazone (111OU81) potently inhibits human cytomegalovirus replication and potentiates the antiviral effects of ganciclovir. Antimicrob Agents Chemo 37: 602-604.
14. 2, dithiothreitol and several nucleotides. Archives of Biochem and Biophys 231: 9-16.
15. Hunting, D., and Henderson, J.F. (1981) Determination of deoxyribonucleoside triphosphates using DNA polymerase: a critical evaluation. Can J Biochem 59: 723-727.
16. Karlsson, A , and Harmenberg, J. (1988) Effects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1. Antimicrob Agents Chemother 32: 1100-1102.
17. Kizaki, H., Shimada, H., Ohsaka, F., and Sakurada, T. (1988) Adenosine, deoxyadenosine, and deoxyguanosine induce DNA cleavage in mouse thymocytes. J Immunol 141: 1652-1657.
18. Lewis, R.A., Watkins, L., and St. Jeor, S. (1984) Enhancement of deoxyguanosine kinase activity in human lung fibroblast cells infected with human cytomegalovirus. Mol Cell Biochem 65: 67-71.
19. McCormick, P.J., Danhauser, L.L., Rustum, Y.M., and Bertram, J.S. (1983) Changes in ribo- and deoxyribonucleoside triphosphate pools within the cell cycle of a synchronized mouse fibroblast cell line. BBA 755: 36-40.
20. Mossman, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63.
21. Noe, D.A., Rowinsky, E.K., Shen, H.-S. L., Clarke, B.V., Grochow, L.B., McGuire, W.B., Hantel, A., Adams, D.B., Abeloff, M.D., Ettinger, D.S., and Donehower, R.C. (1990) Phase I and pharmacokinetic study of brequinar sodium (NSC 368390). Cancer Res 50: 4595-4599.
22. Nutter, L.M., Grill, S.P., and Cheng, Y.-C. (1985) The sources of thymidine nucleotides for virus DNA synthesis in herpes simplex virus type 2-infected cells. J Biol Chem 260: 13272-13275.
23. Reichard, P. (1987) Regulation of Deoxyribotide synthesis. Biochem 26: 3245-8.
24. Schobitz, B., Wolf, S., Christopherson, R.I., and Brand, R. (1991) Nucleotide and nucleic acid metabolism in rat thymocytes during cell cycle progression. BBA 1095: 95-102.
25. St. Jeor, S.C., and Hutt, R. (1977) Cell DNA replication as a function in the synthesis of human cytomegalovirus. J Gen Virol 37: 65-73.
26. Wade, M., Kowalik, T.F., Mudryj, M., Huang, E.-S., and Azizkhan, J.C. (1992) E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection. Molec Cell Biol 12: 4364-4374.
27. Watkins, L., and St. Jeor, S. (1984) Enhancement of deoxyguanosine kinase activity in human lung fibroblast cells infected with human cytomegalovirus. Mol Cell Biochem 65: 67-71.
28. Wright, J.A., Chan, A.K., Choy, B.K., Hurta, R.A.R., McClarty, G.A., and Tagger, A.Y. (1990) Regulation and drug resistance mechanisms of mammalian ribonucleotide reductase and the significance to DNA synthesis. Biochem Cell Biol 68: 1364-71.