Synthesis and antitumor activity of novel duocarmycin derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 11, 1996, Pages 1215-1220

  Asai, Akira ^a   Nagamura, Satoru ^a   Kobayashi, Eiji ^a   Gomi, Katushige ^a   Saito, Hiromitsu ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DUOCARMYCIN B2;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CANCER CHEMOTHERAPY; DRUG DNA INTERACTION; DRUG POTENCY; DRUG SYNTHESIS; MOUSE; NONHUMAN;

ANIMALIA; MURINAE;

EID: 0029953236     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00203-X     Document Type: Article

References (23)

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23. 3) 6a : δ 9.40 (1H, br), 8.43 (1H, s), 7.82 (1H, br), 7.37 (1H, d, J=8.8Hz), 7.21 (1H, dd, J=8.8, 1.7Hz), 6.98 (1H, brs), 6.65 (1H, brs), 5.53 (1H, brs), 4.62 (1H, dd, J=10.6, 9.4Hz), 4.57 (1H, dd, J=10.7, 4.5Hz), 4.23 (1H, m), 4.02 (1H, dd, J=10.1, 3.4Hz), 3.80 (3H, s), 3.79 (3H, s), 3.62 (1H, dd, J=10.0, 8.7Hz), 3.14 (3H, s), 3.05 (3H,s), 1.68 (3H, s). 6b : δ 8.34 (1H, br), 7.52 (1H, d, J=0.9Hz), 7.49 (1H, d, J=9.0Hz), 7.11 (1H, d, J=2.4Hz), 7.07 (1H, dd, J=9.0, 2.4Hz), 5.50 (1H, br), 4.71 (2H, m), 4.22 (1H, m), 3.98 (1H, dd, J=3.3, 10.1Hz), 3.87 (3H, s), 3.78 (3H, s), 3.66 (1H, dd, J=8.4, 10.1Hz), 3.15 (3H, s), 3.05 (3H, s), 1.88 (3H, s). 6c : δ 8.49 (1H, brs), 7.78 (1H, d, J=15.3Hz), 7.55 (2H, d, J=8.7Hz), 6.93 (2H, d, J=8.7Hz), 6.69 (1H, d, 15.3Hz), 5.50 (1H, brs), 4.41 (1H, dd, J=10.7, 10.7Hz), 4.34 (1H, dd, J=4.4, 10.7Hz), 4.19 (1H, m), 4.04 (1H, dd, J=3.2, 10.0Hz), 3.86 (3H, s), 3.77 (3H, s), 3.57 (1H, dd, J=9.5, 9.5Hz), 3.14 (3H, s), 3.05 (3H, s), 1.67 (3H, s). 6d : δ 8.47 (1H, br), 7.75 (1H, d, J=15.2Hz), 7.48 (2H, d, J=8.5Hz), 7.22 (1H, s), 6.72 (2H, d, J=8.5Hz), 6.61 (1H, d, 15.2Hz), 4.39 (1H, dd, J=10.2, 10.2Hz), 4.31 (1H, dd, J=4.4, 10.2Hz), 4.17 (1H, m), 4.02 (1H, dd, J=3.2, 10.0Hz), 3.87 (1H, br), 3.78 (3H, s), 3.57 (1H, dd, J=10.0, 10.0Hz), 3.15 (3H, s), 3.05 (3H, s), 2.91 (3H, s), 1.67 (3H, s). 6e : δ 8.33 (1H, br), 6.93 (2H, d, J=9.1Hz), 6.84 (2H, d, J=9.1Hz), 5.48 (1H, br), 4.73 (1H, d, J=14.1Hz), 4.72 (1H, d, J=14.1Hz), 4.29 (2H, m), 4.15 (1H, m), 3.95 (1H, d, J=3.4, 10.1Hz), 3.76 (3H, s), 3.75 (3H, s), 3.57 (1H, dd, J=10.1, 8.8Hz), 3.12 (3H, s), 3.03 (3H, s), 1.66 (3H, s).