Expression of mRNAs for neurotrophins (NGF, BDNF, and NT-3) and their receptors (p75(NGFR), Trk, TrkB, and TrkC) in human peripheral neuropathies

Neurochemical Research

Volumn 23, Issue 6, 1998, Pages 821-829

  Sobue, Gen ^a   Yamamoto, Masahiko ^a   Doyu, Manabu ^a   Li, Mei ^a,b   Yasuda, Takeshi ^a   Mitsuma, Terunori ^b  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Axonopathy; Cell filtration; Neurotrophins; Peripheral neuropathies; Trks

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CD68 ANTIGEN; MESSENGER RNA; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; NEUROTROPHIN RECEPTOR;

ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; NORTHERN BLOTTING; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

BRAIN-DERIVED NEUROTROPHIC FACTOR; GENE EXPRESSION; HUMANS; MACROPHAGES; MYELIN SHEATH; NERVE DEGENERATION; NERVE GROWTH FACTORS; NERVE REGENERATION; NEUROTROPHIN 3; PERIPHERAL NERVOUS SYSTEM DISEASES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, CILIARY NEUROTROPHIC FACTOR; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKC; RECEPTORS, NERVE GROWTH FACTOR; RNA, MESSENGER; SURAL NERVE; T-LYMPHOCYTES;

EID: 0031979197     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022434209787     Document Type: Article

References (53)

1. Snider, W. 1994. Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77: 627-638.
2. Barbacid, M. 1995. Neurotrophic factors and their receptors. Curr. Opinion Cell Biol. 7:148-155.
3. Snider, W. D., and Wright, D. E. 1996. Neurotrophins cause a new sensation. Neuron 16:229-232.
4. Airaksinen, M. S. Koltzenburg, M., Lewin, G. R., Masu, Y., Helbig, C., Wolf, E., Brem, G., Toyka, K. V., Thoenen, H. 1996. Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation. Neuron 16:287-295.
5. Maisonpierre, P. C., Belluscio, L., Squinto, S., Ip, N. Y., Furth, M. E., Lindsay, R. M., and Yancopoulos, G. D. 1990. Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science 247:1446-1451.
6. Koliatsos, V. E., Clatterbuck, R. E., Winslow, J. W., Cayouette, M. H., and Price, D. L. 1993. Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo. Neuron 10:359-367.
7. Sendtner, M., Holtmann, B., Kolbeck, R., Thoenen, H., and Barde, Y. A. 1992. Brain-derived neurotrophic factor prevents the death of motoneurons in new-born rats after nerve section. Nature 360: 757-759.
8. Klein, R., Jing, S., Nanduri, V., O'Rourke, E., and Barbacid, M. 1991. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65:189-197.
9. Kaplan, D., Hempstead, B. L., Matin-Zanca, D., Chao, M. V., and Parada, L. F. 1991. The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science 252:554-557.
10. Kaplan, D., Martin-Zanca, D., and Parada, L. 1991. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 350:158-160.
11. Klein, R., Nanduri, V., Jing, S., Lamballe, F., Tapley, P., Bryant, S., Cordon-Cardo, C., Jones, K. R., Reichardt, L. F., and Barbacid, M. 1991. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 66: 395-403.
12. Klein, R., Parada, L., Coulier, F., and Barbacid, M. 1989. trkB, a novel tyrosine protein kinase receptor expressed during mouse neuronal development. EMBO J. 8:3701-3709.
13. Squinto, S. P., Stitt, T. N., Aldrich, T. H., Davis, S., Bianco, S. M., Radziejewski, C., Glass, D. J., Masiakowski, P., Furth, M. E., Valenzuela, D. M., DiStefano, P. S., and Yancopoulos, G. D. 1991. trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Cell 65:885-893.
14. Lamballe, F., Klein, R., and Barbacid, M. 1991. trkC, a new member of trk family of tyrosine protein kinase, is a receptor for neurotrophin-3. Cell 66:967-979.
15. Middlemas, D. S., Lindberg, R. A., and Hunter, T. 1991 trKB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol. Cell Biol. 11:143-153.
16. Valenzuela, D. M., Maisonpierre, P. C., Glass, D. J., Rojas, E., Nunez, L., Kong, Y., Gies, D. R., Stitt, T. N., Ip, N. Y., and Yancopoulos, G. D. 1993. Alternative forms of rat TrkC with different functional capabilities. Neuron 10:963-974.
17. Funakoshi, H., Frisén, J., Barbany, G., Timmusk, T., Zachrisson, O., Verge, V. M. K., and Persson, H. 1993. Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. J. Cell Biol. 123:455-465.
18. Taniuchi, M., Clark, H. B., and Johnson E. M. Jr. 1986. Induction of nerve growth factor receptor in Schwann cells after axotomy. Proc. Natl. Acad. Sci. U.S.A. 83:4049-4098.
19. Heumann, R., Korsching, S., Bandtlow, C., and Thoenen, H. 1987. Changes of nerve growth factor synthesis in non-neuronal cells in response to sciatic nerve transection. J. Cell Biol. 104:1623-1631,
20. Heumann, R., Lindholm, D., Bandtlow, C., Meyer, M., Radeke, M. J., Misko, T. P., Shooter, E., and Thenen, H. 1987. Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages. Proc. Natl. Acad. Sci. USA 84: 8735-8739.
21. Matsuoka, I., Meyer, M., and Thoenen, H. 1991. Cell-type-specific regulation of nerve growth factor (NGF) synthesis in non-neuronal cells: comparison of Schwann cells with other cell types. J. Neurosci. 11:3165-3177.
22. Meyer, M., Matsuoka, I., Wetmore, C., Olson, L., and Thoenen, H. 1992. Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J. Cell Biol. 119:45-54.
23. Yamamoto, M., Sobue, G., Li, M., Arakawa, Y., Mitsuma, T., and Kimata, K. 1993. Nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and low-affinity nerve growth factor receptor (LNGFR) mRNA levels in cultured rat Schwann cells; differential time- and dose-dependent regulation by cAMP. Neurosci. Lett. 152:37-40.
24. Sebert, M. E., and Shooter, E. M. 1993. Expression of mRNA for neurotrophic factors and their receptors in the rat dorsal root ganglion and sciatic nerve following nerve injury. J. Neurosci. Res. 36:357-367.
25. Scarpini, E., Ross, A. H., Rosen, J. L., Brown, M. J., Rostami, A., Koprowski, H., and Lisak, R. P. 1988. Expression of nerve growth factor receptor during human peripheral nerve development. Dev. Biol. 125:301-310.
26. Sobue, G., Yasuda, T., Mitsuma, T., Ross, A., and Pleasure, D. 1988. Expression of nerve growth factor receptor in human peripheral neuropathies. Ann. Neurol. 24:64-72.
27. Sobue, G., Yasuda, T., Mitsuma, T., and Pleasure, D. 1989. Nerve growth factor receptor immunoreactivity in the neuronal perikarya of human sensory and sympathetic nerve ganglia. Neurology 39: 937-941.
28. Muragaki, Y., Timothy, N., Leight, S. et al. 1995. Expression of trk receptors in the developing and adult human central and peripheral nervous system. J. Comp. Neurol. 365:387-397.
29. Shelton, D. L., Sutherland, J., Gripp, J., Camerato, T., Armanini, M. P., Phillips, H. S., Carroll, K., Spencer, S. D., and Levinson, A. D. 1995. Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. J. Neurosci. 15:477-491.
30. trk) and low-affinity nerve growth factor receptor (LNGFR) in the adult and aged human peripheral nervous system. Neurosci. Lett. 158:39-43.
31. Yamamoto, M., Sobue, G., Yamamoto, K., Terao, S., and Mitsuma, T. 1996. Expression of mRNAs for neurotrophins and their receptors in the adult human peripheral nervous system and nonneuronal tissues. Neurochem. Res. 21:929-938.
32. Chomczynski, P., and Sacchi, N. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
33. Ullrich, A., Gray, A., Berman, C., and Dull, T. J. 1983. Human beta-nerve growth factor gene sequence highly homologous to that of mouse. Nature 303:821-825.
34. Maisonpierre, P. C., Le Beau, M. M., Espinosa, III R., Ip, N. Y. Belluscio, L., De La Monte, S. M., Squinto, S., Furth, M. E., and Yancopoulos, G. D. 1991. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Genomics 10:558-568.
35. Johnson, D., Lanahan, A., Buck, C. R., Sehgal, A., Morgan, C., Mercer, E., Bothwell, M., and Chao, M. 1986. Expression and structure of the human NGF receptor. Cell 47:545-554.
36. Martin-Zanca, D., Oskam, R., Mitra, G., Copeland, T., and Barbacid, M. 1989. Molecular and biochemical characterization of the human trk proto-oncogene. Mol. Cell. Biol. 9:24-33.
37. Adams, M. D., Kelley, J. M., Gocayne, J. D., Dubnick, M., Polymeropoulos, M. H., Xiao, H., Merril, C. R., Wu, A., Olde, B., Moreno, R. F., Kerlavage, A. R., McCombie, W. R., and Venter, J. C. 1991. Complementary DNA sequencing: expressed sequence tags and human genome project. Science 252:1651-1656.
38. Doyu, M., Sobue, G., Ken, E., Kimata, K., Shinomura, T., Yamada, Y., Mitsuma, T., and Takahashi, A. 1993. Laminin A, B1 and B2 chain gene expression in transected and regenerating nerves: regulation by axonal signals. J. Neurochem. 60: 543-551.
39. Sobue, G., Hashizume, Y., Mukai, E., Hirayama, M., Mitsuma, T., and Takahashi, A. 1989. X-linked recessive bulbospinal neuronopathy. A clinicopathological study. Brain 112:209-232.
40. Pulford, K. A. F., Rigney, E. M., Micklem, K. J., Jones, M., Stross, W. P., Gatter, K. C., and Mason, D. Y. 1989. KP-1: a new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections. J. Clin. Pathol. 42:414-421.
41. Terry, L. A., Brown, M. H., and Beverley, P. C. L. 1988. The monoclonal antibody, UCHL 1, recognize a 180,000 MW component of the human leucocyte-common antigen CD 45. Immunology 64:331-336.
42. Ernfors, P., Rosario, C. M., Merlio, J. P., Grant, G., Aldskogius, H., and Persson, H. 1993. Expression of mRNAs for neurotrophin receptors in the dorsal root ganglion and spinal cord during development and following peripheral or central axotomy. Mol. Brain Res. 17:217-226.
43. Eide, F. F., Vining, E. R., Eide, B. L., Zang, K., Wang, X. Y., and Reichardt, L. F. 1996, Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling. J. Neurosci. 16:3123-3129.
44. Bradley, J. L., Thomas, P. K., King, R. H. M., Muddle, J. R., Ward, J. D., Tesfaye, S., Boulton, A. J. M., Tsigos, C., and Young, R. J. 1995. Myelinated nerve fibre regeneration in diabetic sensory polyneuropathy: correlation with type of diabetes. Acta Neuropathol. 90:403-410.
45. Frisén, J., Verge, V. M., Fried, K., Risling, M., Persson, H., Trotter, J., Hokfelt, T., and Lindholm, D. 1993. Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous system. Proc. Natl. Acad. Sci. USA 90: 4971-4975.
46. Mudo, G., Persson, H., Timmusk, T., Funakoshi, H., Bindoni, M., and Belluardo, N. 1993. Increased expression of trkB and trkC messenger RNAs in the rat forebrain after focal mechanical injury. Neuroscience 57:901-912.
47. Ehlers, M. D., Kaplan, D. R., Price, D. L., and Koliatsos, V. E. 1995. NGF-stimulated retrograde transport of trkA in the mammalian nervous system. J. Cell Biol. 130:149-156.
48. Rariquez-Tebar, A., Dechant, G., Gotz, R., and Barde, Y. A. 1992.Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor. EMBO J. 3:917-922.
49. Wetmore, C., and Olson, L. 1995. Neuronal and nonneuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia suggest new intercellular trophic interactions. J. Comp. Neurol. 353:143-159.
50. McMahon, S. B., Armanini, M. P., Ling, L. H., and Phillips, H. S. 1994. Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets. Neuron 12:1161-1171.
51. Apfel, S. C., Areggo, J. C., Lipson, L., and Kessler, L. A. 1992. Nerve growth factor prevents experimental cisplatin neuropathy. Ann. Neurol. 31:76-80.
52. Gao, W. Q., Dybdal, N., Shinsky, N., Murnane, A., Schmelzer, C., Siegel, M., Keller, G., Hefti, F., Phillips, H. S., and Winslow, J. W. 1995. Neurotrophin-3 reverses experimental cisplatin-induced peripheral sensory neuropathy. Ann. Neurol. 38:30-37.
53. Russel, J. W., Windebank, A. J., and Podrats, J. L. 1994. Role of nerve growth factor in suramin neuropathy studied in vitro. Ann. Neurol. 36:221-228.