Mechanism-based inhibition of the melatonin rhythm enzyme: Pharmacologic exploitation of active site functional plasticity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 22, 1999, Pages 12418-12423

  Khalil, Ehab M ^a   De Angelis, Jacqueline ^a   Ishii, Makoto ^a   Cole, Philip A ^a,b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acetyltransferase; Circadian rhythm; Pineal

Indexed keywords

ACETYL COENZYME A; ACYLTRANSFERASE INHIBITOR; ARALKYLAMINE ACETYLTRANSFERASE; MELATONIN; N ACETYLTRYPTAMINE; SEROTONIN N ACETYLTRANSFERASE; THIOL GROUP;

AFFECTIVE NEUROSIS; ALKYLATION; ANIMAL CELL; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; NONHUMAN; PINEALOCYTE; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT; SLEEP DISORDER;

ANIMALS; ARYLAMINE N-ACETYLTRANSFERASE; BINDING SITES; CATALYSIS; CELLS, CULTURED; ENZYME INHIBITORS; KINETICS; MUTATION; PINEAL GLAND; SHEEP; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 0033607297     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.22.12418     Document Type: Article

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