A 2.8 Å resolution structure of B-phosphogluconate dehydrogenase from the protozoan parasite Trypanosoma brucei: Comparison with the sheep enzyme accounts for differences in activity with coenzyme and substrate analogues

Journal of Molecular Biology

Volumn 282, Issue 3, 1998, Pages 667-681

  Phillips, Christopher ^a,d   Dohnalek, Jan ^b   Gover, Sheila ^a   Barrett, Michael P ^c   Adams, Margaret J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

6 phosphogluconate; Dehydrogenase; NADP; T. brucei; X ray structure

Indexed keywords

DIMER; LIVER ENZYME; MONOMER; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHOSPHOGLUCONATE DEHYDROGENASE; PROTOZOAL PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COENZYME; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE; NONHUMAN; OXIDATIVE STRESS; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; TRYPANOSOMA BRUCEI; X RAY CRYSTALLOGRAPHY; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; ENZYME ACTIVATION; ENZYME SPECIFICITY; GENETICS; METABOLISM; MOLECULAR GENETICS; SEQUENCE ALIGNMENT; SHEEP;

OVIS ARIES; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

AMINO ACID SEQUENCE; ANIMALS; ENZYME ACTIVATION; MOLECULAR SEQUENCE DATA; PHOSPHOGLUCONATE DEHYDROGENASE; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SHEEP; SUBSTRATE SPECIFICITY; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0032566440     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2059     Document Type: Article

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