In Vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists

British Journal of Pharmacology

Volumn 122, Issue 3, 1997, Pages 469-476

  Medhurst, Andrew D ^a   Hay, Douglas W P ^a   Parsons, Andrew A ^a   Martin, Lenox D ^a   Griswold, Don E ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

NK3 receptor antagonists; NK3 receptors; Pupillary constriction; Rabbit iris sphincter muscle; SB 218795; SB 222200; SB 223412; Senktide; SR 142801

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; AMIDE; ATROPINE; N (ALPHA ETHYLBENZYL) 3 METHYL 2 PHENYL 4 QUINOLINECARBOXAMIDE; N [ALPHA (METHOXYCARBONYL)BENZYL] 2 PHENYL 4 QUINOLINECARBOXAMIDE; NEUROKININ 1 RECEPTOR; NEUROKININ 3 RECEPTOR; NEUROKININ 3 RECEPTOR AGONIST; NEUROKININ 3 RECEPTOR ANTAGONIST; NEUROKININ B DERIVATIVE; OSANETANT; SENKTIDE; SUBSTANCE P; TALNETANT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; INTRAOCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MIOSIS; MUSCLE CONTRACTION; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PUPIL; RABBIT; SPHINCTER PUPILLAE MUSCLE; TACHYPHYLAXIS; TOPICAL DRUG ADMINISTRATION;

ANIMALS; IRIS; MALE; MIOSIS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NEUROKININ B; PEPTIDE FRAGMENTS; PIPERIDINES; QUINOLINES; RABBITS; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-3; SUBSTANCE P;

EID: 0030792679     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701406     Document Type: Article

References (22)

1. ARUNLAKSHANA, O. & SCHILD, H.O. (1959). Some quantitative uses of drug antagonism. Br. J. Pharmacol. Chemother., 14, 48-58.
2. BEDING-BARNEKOW, B., BRODIN, E. & HÅKANSON, R. (1988). Substance P, neurokinin A and neurokinin B in the ocular response to injury in the rabbit. Br. J. Pharmacol., 95, 259-267.
3. 3 receptor. Life Sci., 56, 27-32.
4. GIARDINA, G.A.M., SARAU, H.M., FARINA, C., MEDHURST, A.D., GRUGNI, M., FOLEY, J.J., RAVEGLIA, L.F., SCHMIDT, D.B., RIGOLIO, R., VASSALLO, M., VECCHIETTI, V. & HAY, D.W.P. (1996). 2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor. J. Med. Chem., 39, 2281-2284.
5. HALL, J.M., MITCHELL, D. & MORTON, I.K.M. (1991). Neurokinin receptors in the rabbit iris sphincter characterised by novel agonist ligands. Eur. J. Pharmacol., 199, 9-14.
6. HALL, J.M., MITCHELL, D. & MORTON, I.K.M. (1993). Tachykinin receptors mediating responses to sensory nerve stimulation and exogenous tachykinins and analogues in the rabbit isolated iris sphincter muscle. Br. J. Pharmacol., 109, 1008-1013.
7. 1 tachykinin receptor characteristics in the rabbit isolated iris sphincter. Br. J. Pharmacol., 112, 985-991.
8. MCLEAN, S., GANONG, A., SEYMOUR, P.A., SNIDER, R.M., DESAI, M.C., ROSEN, T., BRYCE, D.K., LONGO, K.P., REYNOLDS, L.S., ROBINSON, G., SCHMIDT, A.W., SIOK, C. & HEYM, J. (1993). Pharmacology of CP-99,994: a nonpeptide antagonist of the tachykinin neurokinin-1 receptor. J. Pharmacol. Exp. Ther., 267, 472-479.
9. 3 receptors in rabbit isolated iris sphincter muscle. Br. J. Pharmacol., 120, 93-101.
10. PEIFFER JR, R.L., POHM-THORSEN, L. & CORCORAN, K (1994). Models in ophthalmology and vision research. In The Biology of the Laboratory Rabbit. ed Manning, P.J., Ringler, D.H. & Newcomer, D.E. pp. 409-431. New York: Academic Press.
11. 3 antagonist in the guinea-pig but not in the rat. Biochem Biophys. Res. Commun., 191, 180-187.
12. PICARD, P., REGOLI, D. & COUTURE, R. (1994). Cardiovascular and behavioural effects of centrally administered tachykinins in the rat: characterisation of receptors with selective antagonists. Br. J. Pharmacol., 112, 240-249.
13. 3 receptor agonists in the guinea-pig. Br. J. Pharmacol., 116, 2496-2502.
14. SARAU, H.M., GRISWOLD, D.E., POTTS, W., FOLEY, J.J., SCHMIDT, D.B., MARTIN, L.D., BRAWNER, M.E., ELSHOURBAGY, N.A., MEDHURST, A.D., GIARDINA, G.A.M. & HAY, D.W.P. (1997). Nonpeptide tachykinin receptor antagonists. I. Pharmacological and pharmacokinetic characterisation of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. J. Pharmacol. Exp. Ther., 281, 1303-1311.
15. 3 tachykinin agonist senktide in rodents: evidence for mediation by endogenous 5-HT. Brain Res., 517, 111-116.
16. STOESSL, AJ., DOURISH, C.T., YOUNG, S.C., WILLIAMS, B.J., IVERSON, S.D. & IVERSON, L.L. (1987). Senktide, a selective neurokinin B-like agonist, elicits serotonin-mediated behaviour following intracisternal administration in the mouse. Neurosci. Lett., 80, 321-326.
17. TANIGUCHI, T., FUJIWARA, M., MASUO, Y. & KANAZAWA, I. (1986). Levels of neurokinin A, neurokinin B and substance P in rabbit iris sphincter muscle. Jpn. J. Pharmacol., 42, 590-593.
18. UEDA, N., MURAMATSU, I. & FUJIWARA, M. (1984). Capsaicin and bradykinin-induced substance P-nergic responses in the iris sphincter muscle of the rabbit. J. Pharmacol. Exp. Ther., 230, 469-473.
19. UEDA, N., MURAMATSU, I., HAYASHI, H. & FUJIWARA, M. (1982). Trigeminal nerve: The possible origin of substance P-ergic response in isolated rabbit iris sphincter muscle. Life Sci., 31, 369-375.
20. 1 receptors only. Eur. J. Pharmacol., 216, 327-329.
21. 2 receptors: a study with selective agonists and antagonists. Regul. Peptides, 44, 269-275.
22. WORMSER, U., LAUFER, R., HART, Y., CHOREV, M., GILON, C. & SELINGER, Z. (1986). Highly selective agonists for substance P receptor subtypes. EMBO J., 5, 2805-2808.