Synthesis of a difluorophosphonomethyl-containing phosphatase inhibitor designed from the X-ray structure of a PTP1B-bound ligand

Tetrahedron

Volumn 52, Issue 30, 1996, Pages 9963-9970

  Ye, Bin ^a   Burke Jr , Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; NAPHTHALENE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR;

ARTICLE; COMPLEX FORMATION; COMPUTER SIMULATION; DRUG DESIGN; DRUG SYNTHESIS; ENZYME BINDING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TECHNIQUE; X RAY ANALYSIS;

EID: 0030598031     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4020(96)00531-5     Document Type: Article

References (17)

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2. 2. Chatterjee, S.; Goldstein, B. J.; Csermely, P.; Shoelson, S. E. Phosphopeptide substrates and phosphonopeptide inhibitors of protein-tyrosine phosphatases. In Peptides: Chemistry and Biology; Rivier, J. E.; Smith, J. A. Eds.; Escom Science Publishers: Leiden, Netherlands, 1992; pp. 553-555.
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