A traceless linker approach to the solid phase synthesis of substituted guanidines utilizing a novel acyl isothiocyanate resin

Tetrahedron Letters

Volumn 40, Issue 21, 1999, Pages 3999-4002

  Wilson, Lawrence J ^a   Klopfenstein, Sean R ^a   Li, Min ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

Combinatorial chemistry; EDC; Guanidines; Isothiocyanate; Solid phase synthesis

Indexed keywords

(3 IODOBENZYL)GUANIDINE; 1,1 DIMETHYL 2 (2 MORPHOLINOPHENYL)GUANIDINE FUMARATE; ACYL ISOTHIOCYANIC ACID; ANTINEOPLASTIC AGENT; GUANIDINE DERIVATIVE; ISOTHIOCYANIC ACID DERIVATIVE; N 4 IODOPHENYL N' ADAMANTYL GUANIDINE; OPIATE ANTAGONIST; RESIN; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; STEREOCHEMISTRY;

EID: 0033591179     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00663-2     Document Type: Article

References (33)

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31. -1): 3040, 2930, 1970 (N=C=S), 1700 (C=O), 1600, 1500, 1450, 1250, 1170, 1070, 1030, 910.
32. 12. These compounds were identical by HPLC and TLC with authentic samples which were purchased from their corresponding vendors: (a) entry 1 - Sigma #I9890; (b) entry 6 - ICN #158938; (c) entry 7 - Aldrich #D20,775-6.
33. 19F NMR, MS, and HPLC spectra.