Preparation of N,N'-bis(aryl)guanidines from electron deficient amines via masked carbodiimides

Tetrahedron Letters

Volumn 38, Issue 39, 1997, Pages 6799-6802

  Barvian, Mark R ^a   Showalter, H D Hollis ^a   Doherty, Annette M ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; CYANAMIDE; GUANIDINE DERIVATIVE; N,N' BIS(ARYL)GUANIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0030763758     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01598-0     Document Type: Article

References (19)

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14. All new compounds afforded consistent characterization.
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16. 3): 7.25 (d, J= 7.3 Hz, 2H), 7.07 (dd, J= 7.3, 7.3 Hz, 3H), 3.11 (s, 3H). IR (KBr) 3469, 2930, 2854, 2120, 1449, 1359, 1345, 1345.
17. A similar observation was made using di-2-pyridyl thionocarbonate as a dehydrating agent: Tetrahedron Lett., 1985, 26, 1161.
18. 4: C, 81.91; H, 5.77; N, 12.32. Found: C, 81.95; H, 5.92; N, 12.06.
19. 4 · 2.25 HCl: C, 48.65; H, 5.53; N, 18.91. Found: C, 43.64; H, 5.37; N, 18.62.