Catalytic racemisation of alcohols: Applications of enzymatic resolution reactions

Tetrahedron Letters

Volumn 37, Issue 42, 1996, Pages 7623-7626

  Dinh, Phi M ^a   Howarth, Judith A ^a   Hudnott, Anna R ^a   Williams, Jonathan M J ^a   Harris, William ^b  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^b ROCHE PRODUCTS LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANOL;

ARTICLE; DRUG PURIFICATION; ENANTIOMER; TECHNIQUE;

EID: 0030583519     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01677-2     Document Type: Article

References (17)

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2. 1. Enzyme Catalysis in Organic Synthesis, ed. Drauz, K.; Waldman, H. VCH, Weinheim, 1995, vol. 1, 165-343. Naemura, K.; Fukuda, R.; Murata, M.; Konishi, M.; Hirose, K.; Tobe, Y. Tetrahedron: Asymmetry, 1995, 6, 2385-2394. Burgess, K.; Jennings, L.D. J. Am. Chem. Soc., 1991, 113, 6129-6139.
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4. 2. Recently we have shown that the palladium catalysed racemisation of suitable allylic acetates is possible in the presence of Pseudomonas fluorescens Lipase. Allen, J.V.; Williams, J.M.J. Tetrahedron Lett., 1996, 37, 1859-1862.
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17. 12. The use of the higher temperature (up to 80 °C) was not responsible for the lower selectivities. Thus, the PFL catalysed acylation of phenethyl alcohol 1 at 80 °C in the absence of any co-catalyst afforded the product in 95% ee at 43% conversion after 24 hours.