Acquired constitutive expression of interferon β after gene transduction enhances human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity by a RANTES-dependent mechanism

Human Gene Therapy

Volumn 10, Issue 11, 1999, Pages 1803-1810

  Hadida, F ^a   De Maeyer, E ^b   Cremer, I ^b   Autran, B ^a   Baggiolini, M ^c   Debre P ^a   Vieillard, V ^d  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b INSTITUT CURIE   (France)

^c UNIVERSITY OF BERN   (Switzerland)

^d HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; GAG PROTEIN; POL PROTEIN; RANTES; VIRUS ENVELOPE PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIGEN SPECIFICITY; ARTICLE; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; GENE OVEREXPRESSION; GENE THERAPY; GENETIC TRANSCRIPTION; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MAJOR HISTOCOMPATIBILITY COMPLEX; PROTEIN EXPRESSION;

CYTOTOXICITY, IMMUNOLOGIC; FLOW CYTOMETRY; GENE THERAPY; GENETIC VECTORS; HIV INFECTIONS; HIV-1; HUMANS; INTERFERON-BETA; RANTES; RECEPTORS, CHEMOKINE; RETROVIRIDAE; T-LYMPHOCYTES, CYTOTOXIC; TRANSDUCTION, GENETIC;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0033587548     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950017482     Document Type: Article

References (34)

1. AUTRAN, B., GOMARD, E., RIVIÈRE, Y., AGUT, H., BOULET, J.M., and KATLAMA, C. (1996a). Prospective follow-up studies of HIV-specific cytotoxic T lymphocytes (CTL) in a French cohort of 150 patients. IMMUNOCO. In XIth International Conference on AIDS, Vancouver. p. 222, Abstract TU.A280.
2. AUTRAN, B., HADIDA, F., and HAAS, G. (1996b). Evolution and plasticity of CTL responses against HIV. Curr Opin. Immunol. 8, 546-553.
3. BAGGIOLINI, M., DEWALD, B., and MOSER, B. (1997). Human chemokines: An update. Annu. Rev. Immunol. 15, 675-705.
4. BHATIA, R., McGLAVE, P.B., and VERFAILLIE, C.M. (1995). Treatment of marrow stroma with interferon-α restores normal β1 integrin dependent adhesion of chronic leukemia hematopoietic progenitors. Role of MIP-1α. J. Clin. Invest. 96, 931-939.
5. BRIDGES, S.H., and SARVER, N. (1995). Gene therapy and immune restoration for HIV disease. Lancet 345, 427-432.
6. CLARK-LEWIS, I., MOSER, B., WALZ, A., BAGGIOLINI, M., SCOTT, G.J., and AEBERSOLD, R. (1991). Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide 2. Biochemistry 30, 3128-3135.
7. + T cells. Science 270, 1811-1815.
8. + human hematopoietic progenitor cells: Correlation with a down-regulation of CCR-5 expression. Virology 253, 241-249.
9. DANOS, O., and MULLIGAN, R.C. (1988). Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. Proc. Natl. Acad. Sci. U.S.A. 85, 6460-6464.
10. D'SOUZA, M.P., and HARDEN, V.A. (1996). Chemokines and HIV-1 second receptors: Confluence of two fields generates optimism in AIDS research. Nature Med. 2, 1293-1300.
11. FRANCIS, M.L., MELTZER, M.S., and GENDELMAN, H.E. (1992). Interferons in the persistence, pathogenesis and treatment of HIV infection. AIDS Res. Hum. Retroviruses 8, 199-207.
12. HADIDA, F., PARROT, A., KIENY, M.P., SADAT-SOWETI, B., MAYAUD, C., DEBRÉ, P., and AUTRAN, B. (1992). Carboxyl-terminal and central regions of human immunodeficiency virus-1 Nef recognized by cytotoxic T lymphocytes from lymphoid organs. An in vitro limiting dilution analysis. J. Clin. Invest. 89, 53-60.
13. HADIDA, F., HAAS, G., ZIMERMANN, N., HOSMALIN, A., SPOHN, S., JUNG, R., DEBRÉ, P., and AUTRAN, B. (1995). Cytotoxic T lymphocytes from lymphoid organs recognize an optimal HLA-A2 and -B52 restricted nonapeptide and several epitopes in the C-terminal region of HIV-1 Nef. J. Immunol. 154, 4174-4186.
14. HADIDA, F., VIEILLARD, V., AUTRAN, B., CLARK-LEWIS, I., BAGGIOLINI, M., and DEBRÉ, P. (1998). HIV-specific T cell cytotoxicity mediated by RANTES via the chemokine receptor CCR3. J. Exp. Med. 188, 609-614.
15. HAWLEY, R.G., SABOURIN, L.A., and HAWLEY, T.S. (1989). An improved retroviral vector for gene transfer into undifferentiated cells. Nucleic Acids Res. 17, 4001-4008.
16. HOFFENBACH, A., LANGLADE-DEMOYEN, P., DADAGLIO, G., VILMER, E., MICHEL, F., MAYAUD, C., AUTRAN, B., and PLATA, F. (1989). Unusually high frequencies of HIV-specific T lymphocytes in humans. J. Immunol. 142, 452-462.
17. + T lymphocytes are required for the synergetic action of interferon α/β and adoptively transferred immune cells in the inhibition of visceral ESb metastases. Cancer Res. 55, 6133-6139.
18. KOENING, S., CONLEY, A.J., BREWAH, Y.A., JONES, G.M., LEATH, S., BOOTS, L.I., DAVEY, V., PANTALEO, G., DEMAREST, J.F., CARTER, C., WANNEBO, C., YANNELLI, J.R., ROZENBERG, S.A., and LANE, H.C. (1995). Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression. Nature Med. 4, 330-337.
19. LIEBERMAN, J., FABRY, J.A., SHANKAR, P., BECKETT, J., and SKOLNICK, P.R. (1995). Ex vivo expansion of HIV type-1 specific cytolytic T cells from HIV type 1-seropositive subjects. AIDS Res. Hum. Retroviruses 11, 257-271.
20. 2+ mobilization, and enzyme release. J. Immunol. 156, 322-327.
21. MÜLLER, U., STEINHOFF, U., REIS, L.F.L., HEMMI, S., PAVLOVIC, J., ZINKERNAGEL, R.M., and AGUET, M. (1994). Functional role of type I and type II interferons in antiviral defence. Science 264, 1918-1921.
22. MUSEY, L., HUGHES, J., SCHACKER, T., SHEA, T., and COREY, L. (1997). Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection. N. Engl. J. Med. 337, 1267-1274.
23. NIXON, D.F., TOWNSEND, A.R.M., ELVIN, J.G., RIZZA, C.R., GALLWEY, J., and McMICHAEL, A.J. (1988). HIV-1 Gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides. Nature (London) 336, 484-487.
24. PANTALEO, G. (1997). How immune-based interventions can change HIV therapy. Nature Med. 3, 483-486.
25. PODACK, E.R., HENGARTNER, H., and LICHTENHELD, M.G. (1991). A central role of perform in cytolysis? Annu. Rev. Immunol. 9, 129-157.
26. SAMSON, F., LIBERT, M., DORANZ, B.J., RUCKER, J., LIESNARD, C., FARBER, C.M., SARAGOSTI, S., LAPOUMEROULIE, C., COGNAUX, J., FORCEILLE, C., MUYLDERMAN, G., VERHOFOTEDE, C., BURTONBOY, G., GEORGES, M., IMAI, T., RANA, S., YI, Y., SMYTH, R.J., COLLMAN, R.G., DOMS, R.W., VASSART, G., and PARMENTIER, M. (1996). Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature (London) 382, 722.
27. SONOUCHI, K., HAMILTON, T.A., TANNENBAUM, C.S., TUBBS, R.R., BUKOWSKI, R., and FINKE, J.H. (1994). Chemokine gene expression in the murine renal cell carcinoma, following treatment in vivo with interferon-α and interleukin-2. Am. J. Pathol. 144, 747-755.
28. TOUGH, D.F., BORROW, P., and SPRENT, J. (1996). Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 272, 1947-1950.
29. TSCHOPP, J., and NABHOLZ, M. (1990). Perforin-mediated target cell lysis by cytolytic T lymphocytes. Annu. Rev. Immunol. 8, 279-302.
30. VIEILLARD, V., LAURET, E., ROUSSEAU, V., and DE MAEYER, E. (1994). Blocking of retroviral infection at a step prior to reverse transcription in cells transformed to constitutively express interferon β. Proc. Natl. Acad. Sci. U.S.A. 91, 2689-2693.
31. VIEILLARD, V., LAURET, E., MAGUER, V., JACOMET, C., ROZENBAUM, W., GAZZOLO, L., and DE MAEYER, E. (1995). Autocrine interferon-β synthesis for gene therapy of HIV infection: increased resistance to HIV-1 in lymphocytes from healthy and HIV-infected individuals. AIDS 9, 1221-1228.
32. VIEILLARD, V., CREMER, I., LAURET, E., ROZENBAUM, W., DEBRÉ, P., AUTRAN, B., and DE MAEYER, E. (1997). Interferon beta transduction of PBL from HIV-infected donors increases Th-1-type cytokine production, and improves the proliferative response to recall antigens. Proc. Natl. Acad. Sci. U.S.A. 94, 11595-11600.
33. VON HOEGEN, P. (1995). Synergetic role of type I interferons in the induction of protective cytotoxic T lymphocytes. Immunol. Lett. 47, 157-162.
34. YU, M., POESCHA, E., and WONG-STAAL, F. (1994). Progress towards gene therapy for HIV infection. Gene Ther. 1, 13-26.