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1
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0029148848
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Can the immune response control HIV infection?
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Paul WE. Can the immune response control HIV infection? Cell. 82:1995;177-182.
-
(1995)
Cell
, vol.82
, pp. 177-182
-
-
Paul, W.E.1
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2
-
-
0028874048
-
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
-
of outstanding interest. Shows experimental data and mathematical analysis of the extraordinarily high rates of viral turnover and clearance as well as CD4 turnover after HIV-specific treatment with a protease inhibitor.
-
Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. of outstanding interest Nature. 373:1995;123-126 Shows experimental data and mathematical analysis of the extraordinarily high rates of viral turnover and clearance as well as CD4 turnover after HIV-specific treatment with a protease inhibitor.
-
(1995)
Nature
, vol.373
, pp. 123-126
-
-
Ho, D.D.1
Neumann, A.U.2
Perelson, A.S.3
Chen, W.4
Leonard, J.M.5
Markowitz, M.6
-
3
-
-
0028811974
-
Viral dynamics in Human Immunodeficiency Virus type 1 infection
-
of outstanding interest. This is an impressive study on viral dynamics in the course of antiretroviral treatment which complements work presented in [2].
-
Wei W, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH, et al. Viral dynamics in Human Immunodeficiency Virus type 1 infection. of outstanding interest Nature. 373:1995;117-122 This is an impressive study on viral dynamics in the course of antiretroviral treatment which complements work presented in [2].
-
(1995)
Nature
, vol.373
, pp. 117-122
-
-
Wei, W.1
Ghosh, S.K.2
Taylor, M.E.3
Johnson, V.A.4
Emini, E.A.5
Deutsch, P.6
Lifson, J.D.7
Bonhoeffer, S.8
Nowak, M.A.9
Hahn, B.H.10
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5
-
-
0029131504
-
Are HIV-specific CTL responses salutary or pathogenic?
-
Zinkernagel RM. Are HIV-specific CTL responses salutary or pathogenic? Curr Biol. 7:1995;462-470.
-
(1995)
Curr Biol
, vol.7
, pp. 462-470
-
-
Zinkernagel, R.M.1
-
6
-
-
0028337166
-
Temporal association of cellular immune responses with the initial control of viremia in primary Human Immunodeficiency Virus Type 1 Syndrome
-
Koup RA, Safrit JT, Cao Y, Andrews A, McLeod, Borkosky W, Farthing C, Ho DD. Temporal association of cellular immune responses with the initial control of viremia in primary Human Immunodeficiency Virus Type 1 Syndrome. J Virol. 68:1994;4650-4655.
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(1994)
J Virol
, vol.68
, pp. 4650-4655
-
-
Koup, R.A.1
Safrit, J.T.2
Cao, Y.3
Andrews, A.4
McLeod5
Borkosky, W.6
Farthing, C.7
Ho, D.D.8
-
7
-
-
0028041344
-
+ cytotoxic T lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
-
+ cytotoxic T lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol. 68:1994;6103-6110.
-
(1994)
J Virol
, vol.68
, pp. 6103-6110
-
-
Borrow, P.1
Lewicki, H.2
Hahn, B.H.3
Shaw, G.M.4
Oldstone, M.B.5
-
8
-
-
0027979442
-
Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: Recognition of autologous virus sequences within a conserved immunodominant epitope
-
Safrit JT, Andrews CA, Zhu T, Ho DD, Koup RA. Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: recognition of autologous virus sequences within a conserved immunodominant epitope. J Exp Med. 179:1994;463-472.
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(1994)
J Exp Med
, vol.179
, pp. 463-472
-
-
Safrit, J.T.1
Andrews, C.A.2
Zhu, T.3
Ho, D.D.4
Koup, R.A.5
-
9
-
-
0028061862
-
A region of the third variable loop of HIV-1 gp120 is recognized by HLA-B7-restricted CTLs from two acute seroconversion patients
-
Safrit JT, Lee AY, Andrews CA, Koup RA. A region of the third variable loop of HIV-1 gp120 is recognized by HLA-B7-restricted CTLs from two acute seroconversion patients. J Immunol. 153:1994;3822-3830.
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(1994)
J Immunol
, vol.153
, pp. 3822-3830
-
-
Safrit, J.T.1
Lee, A.Y.2
Andrews, C.A.3
Koup, R.A.4
-
10
-
-
0028929463
-
Different patterns of HIV-1-specific cytotoxic T lymphocyte activity after primary infection
-
Lamhamedi-Cherradi S, Culmann-Penciolelli B, Guy B, Duong Ly T, Goujard C, Guillet JG, Gomard E. Different patterns of HIV-1-specific cytotoxic T lymphocyte activity after primary infection. AIDS. 9:1995;421-426.
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(1995)
AIDS
, vol.9
, pp. 421-426
-
-
Lamhamedi-Cherradi, S.1
Culmann-Penciolelli, B.2
Guy, B.3
Duong Ly, T.4
Goujard, C.5
Guillet, J.G.6
Gomard, E.7
-
11
-
-
0027979037
-
+ T cells with a predominant Vβ usage during the primary immune response to HIV
-
+ T cells with a predominant Vβ usage during the primary immune response to HIV. Nature. 370:1994;463-467.
-
(1994)
Nature
, vol.370
, pp. 463-467
-
-
Pantaleo, G.1
Demarest, J.F.2
Soudeyns, H.3
Graziosi, C.4
Denis, F.5
Adeisberger, J.W.6
Borrow, P.7
Saag, M.S.8
Shaw, G.M.9
Sekaly, R.10
Fauci, A.S.11
-
12
-
-
0027965585
-
+ cell levels
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+ cell levels. J Infect Dis. 170:1994;775-781.
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(1994)
J Infect Dis
, vol.170
, pp. 775-781
-
-
Giorgi, J.V.1
Ho, H.N.2
Hirji, K.3
Chou, C.C.4
Hultin, L.E.5
ORourke, S.6
Park, L.7
Margolick, J.B.8
Ferbas, J.9
Phair, J.P.10
-
13
-
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0024578238
-
Very high frequencies of HIV specific cytotoxic T lymphocytes in humans
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Hoffenbach A, Langlade-Demoyen P, Vilmer E, Dadaglio G, Michel F, Mayaud C, Autran B, Plata F. Very high frequencies of HIV specific cytotoxic T lymphocytes in humans. J Immunol. 142:1989;452-456.
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(1989)
J Immunol
, vol.142
, pp. 452-456
-
-
Hoffenbach, A.1
Langlade-Demoyen, P.2
Vilmer, E.3
Dadaglio, G.4
Michel, F.5
Mayaud, C.6
Autran, B.7
Plata, F.8
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14
-
-
0024313784
-
Cell mediated suppression of HIV-specific cytotoxic T lymphocytes
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Joly P, Guillon JM, Mayaud C, Plata F, Theodorou I, Denis M, Debre P, Autran B. Cell mediated suppression of HIV-specific cytotoxic T lymphocytes. J Immunol. 143:1989;2193-2201.
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(1989)
J Immunol
, vol.143
, pp. 2193-2201
-
-
Joly, P.1
Guillon, J.M.2
Mayaud, C.3
Plata, F.4
Theodorou, I.5
Denis, M.6
Debre, P.7
Autran, B.8
-
15
-
-
0025118874
-
High frequency of memory and effector Gag-specific cytotoxic T lymphocytes in HIV seropositive individuals
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Gotch FM, Nixon DF, Alp N, McMichael AJ, Borysievicz LK. High frequency of memory and effector Gag-specific cytotoxic T lymphocytes in HIV seropositive individuals. Int Immuno. 2:1990;707-712.
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(1990)
Int Immuno
, vol.2
, pp. 707-712
-
-
Gotch, F.M.1
Nixon, D.F.2
Alp, N.3
McMichael, A.J.4
Borysievicz, L.K.5
-
16
-
-
0028978720
-
Gag-specific cytotoxic responses to HIV type 1 are associated with a decreased risk of progression to AIDS-related complex or AIDS
-
of special interest. One of those rare studies that can show a correlation between CTL recognition and lack of disease progression.
-
Rivière Y, McChesney MB, Porrot F, Tanneau-Salvadori F, Sansonetti P, Lopez O, Pialoux G, Feuillie V, Mollereau M, Chamaret S, et al. Gag-specific cytotoxic responses to HIV type 1 are associated with a decreased risk of progression to AIDS-related complex or AIDS. of special interest AIDS Res Hum Retroviruses. 118:1995;903-907 One of those rare studies that can show a correlation between CTL recognition and lack of disease progression.
-
(1995)
AIDS Res Hum Retroviruses
, vol.118
, pp. 903-907
-
-
Rivière, Y.1
McChesney, M.B.2
Porrot, F.3
Tanneau-Salvadori, F.4
Sansonetti, P.5
Lopez, O.6
Pialoux, G.7
Feuillie, V.8
Mollereau, M.9
Chamaret, S.10
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17
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-
14844341454
-
Cytotoxic T lymphocytes from lymphoid organs recognize an optimal HLA-A2 and -B52 restricted nonpeptide and several epitopes in the C-terminal region of HIV-1 Nef
-
of special interest. In this study a new CTL epitope is defined in the carboxy-terminal region of Nef as recognized in the context of several HLA-A2 subtypes; the functional definition correlates with findings of CTL recognition in the context of several HLA-A2 subtypes.
-
Hadida F, Haas G, Zimmermann N, Hosmalin A, Spohn R, Jung R, Debré P, Autran B. Cytotoxic T lymphocytes from lymphoid organs recognize an optimal HLA-A2 and -B52 restricted nonpeptide and several epitopes in the C-terminal region of HIV-1 Nef. of special interest J Immunol. 154:1995;4174-4186 In this study a new CTL epitope is defined in the carboxy-terminal region of Nef as recognized in the context of several HLA-A2 subtypes; the functional definition correlates with findings of CTL recognition in the context of several HLA-A2 subtypes.
-
(1995)
J Immunol
, vol.154
, pp. 4174-4186
-
-
Hadida, F.1
Haas, G.2
Zimmermann, N.3
Hosmalin, A.4
Spohn, R.5
Jung, R.6
Debré, P.7
Autran, B.8
-
18
-
-
0029008971
-
+ T lymphocytes in spleens of human immunodeficiency virus-positive patients
-
of special interest. A study based on limiting dilution polymerase chain reactions showing that a very small fraction of dendritic are infected with HIV in the lymphoid organs.
-
+ T lymphocytes in spleens of human immunodeficiency virus-positive patients. of special interest J Virol. 69:1995;4737-4745 A study based on limiting dilution polymerase chain reactions showing that a very small fraction of dendritic are infected with HIV in the lymphoid organs.
-
(1995)
J Virol
, vol.69
, pp. 4737-4745
-
-
Mcllroy, D.1
Autran, B.2
Cheynier, R.3
Wain-Hobson, S.4
Clauvel, J.P.5
Oksenhendler, E.6
Debré, P.7
Hosmalin, A.8
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19
-
-
0028938947
-
+ positive cytotoxic lymphocytes in Acquired Immunodeficiency Syndrome lymphomas
-
of special interest. This study indicates that primed CTL effectors persist in lymphoid organs and tumors in AIDS patients and suggest that at this stage the Th1 defect does not impair amplification and persistence of effector CTLs in vivo.
-
+ positive cytotoxic lymphocytes in Acquired Immunodeficiency Syndrome lymphomas. of special interest Hum Pathol. 26:1995;284-290 This study indicates that primed CTL effectors persist in lymphoid organs and tumors in AIDS patients and suggest that at this stage the Th1 defect does not impair amplification and persistence of effector CTLs in vivo.
-
(1995)
Hum Pathol
, vol.26
, pp. 284-290
-
-
Devergne, O.1
Raphael, M.2
Autran, B.3
Leger-Ravet, M.B.4
Coumbaras, J.5
Crevon, M.C.6
Galanaud, P.7
Emilie, D.8
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20
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0022967777
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+ lymphocytes can control HIV infection in vitro by suppressing virus replication
-
+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science. 234:1986;1563-1565.
-
(1986)
Science
, vol.234
, pp. 1563-1565
-
-
Walker, C.M.1
Moody, D.J.2
Stites, D.P.3
Levy, J.A.4
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22
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0029119411
-
Oligoclonal CD8 lymphocytes from persons with asymptomatic human immunodeficiency virus (HIV) type 1 infection inhibit HIV-1 replication
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Toso JF, Chen CH, Mohr JR, Piglia L, Oei C, Ferrari G, Greenberg ML, Weinhood KJ. Oligoclonal CD8 lymphocytes from persons with asymptomatic human immunodeficiency virus (HIV) type 1 infection inhibit HIV-1 replication. J Infect Dis. 172:1995;964-973.
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(1995)
J Infect Dis
, vol.172
, pp. 964-973
-
-
Toso, J.F.1
Chen, C.H.2
Mohr, J.R.3
Piglia, L.4
Oei, C.5
Ferrari, G.6
Greenberg, M.L.7
Weinhood, K.J.8
-
23
-
-
0027945247
-
+ cytotoxic T lymphocytes protect human peripheral blood leukocyte-severe combined immunodeficient mice from HIV-1 infection by an HLA-unrestricted mechanism
-
+ cytotoxic T lymphocytes protect human peripheral blood leukocyte-severe combined immunodeficient mice from HIV-1 infection by an HLA-unrestricted mechanism. J Immunol. 153:1995;4826-4833.
-
(1995)
J Immunol
, vol.153
, pp. 4826-4833
-
-
Van Kuyk, R.1
Torbett, B.E.2
Gulizia, R.J.3
Leath, S.4
Mosier, D.E.5
Koenig, S.6
-
24
-
-
0029072719
-
Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors
-
of special interest. This study shows frequencies of TCR CDR3 subsets of HIV-specific CTLs using a polymerase chain reaction limiting-dillution technique.
-
Moss PAH, Rowland-Jones SL, Frodsham PM, McAdam S, Giangrande P, McMichael AJ, Bell JI. Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors. of special interest Proc Natl Acad Sci USA. 92:1995;5773-5777 This study shows frequencies of TCR CDR3 subsets of HIV-specific CTLs using a polymerase chain reaction limiting-dillution technique.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5773-5777
-
-
Moss, P.A.H.1
Rowland-Jones, S.L.2
Frodsham, P.M.3
McAdam, S.4
Giangrande, P.5
McMichael, A.J.6
Bell, J.I.7
-
25
-
-
0028950823
-
Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: A longitudinal analysis of rapid progressors and long-term asymptomatics
-
of special interest. A comparative study to determine factors for rapid disease progression.
-
Klein MR, VanBaalen CA, Holwerda AM, Garde KSR, Bende RJ, Keet IPM, Eeftinck-Schattenkerk JKM, Osterhaus ADME, Schuitemaker H, Miedema F. Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics. of special interest J Exp Med. 181:1995;1365-1372 A comparative study to determine factors for rapid disease progression.
-
(1995)
J Exp Med
, vol.181
, pp. 1365-1372
-
-
Klein, M.R.1
VanBaalen, C.A.2
Holwerda, A.M.3
Garde, K.S.R.4
Bende, R.J.5
Keet, I.P.M.6
Eeftinck-Schattenkerk, J.K.M.7
Osterhaus, A.D.M.E.8
Schuitemaker, H.9
Miedema, F.10
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26
-
-
0028323247
-
Longitudinal analysis of T cell receptor (TCR) gene usage by Human Immunodeficiency Virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire
-
Kalams SA, Johnson RP, Trocha AK, Dynan MJ, Ngo HS, D'aguila RT, Kurnick JT, Walker BD. Longitudinal analysis of T cell receptor (TCR) gene usage by Human Immunodeficiency Virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. J Exp Med. 179:1994;1261-1271.
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(1994)
J Exp Med
, vol.179
, pp. 1261-1271
-
-
Kalams, S.A.1
Johnson, R.P.2
Trocha, A.K.3
Dynan, M.J.4
Ngo, H.S.5
D'aguila, R.T.6
Kurnick, J.T.7
Walker, B.D.8
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27
-
-
0027959373
-
HIV and T cell expansion in splenic white pulps is accompanied by infiltration of HIV-specific cytotoxic T lymphocytes
-
Cheynier R, Henrichwark S, Hadida F, Pelletier E, Oksenhendler E, Autran B, Wain-Hobson W. HIV and T cell expansion in splenic white pulps is accompanied by infiltration of HIV-specific cytotoxic T lymphocytes. Cell. 78:1994;373-387.
-
(1994)
Cell
, vol.78
, pp. 373-387
-
-
Cheynier, R.1
Henrichwark, S.2
Hadida, F.3
Pelletier, E.4
Oksenhendler, E.5
Autran, B.6
Wain-Hobson, W.7
-
28
-
-
0028176469
-
Normal immune function and inability to isolate virus in culture in an individual with long-term human immunodeficiency virus type 1 infection
-
Greenough TC, Somasundaran M, Brettler DB, Hesselton RM, Alimenti A, Kirschoff F, Panicali D, Sullivan JL. Normal immune function and inability to isolate virus in culture in an individual with long-term human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses. 10:1994;395-403.
-
(1994)
AIDS Res Hum Retroviruses
, vol.10
, pp. 395-403
-
-
Greenough, T.C.1
Somasundaran, M.2
Brettler, D.B.3
Hesselton, R.M.4
Alimenti, A.5
Kirschoff, F.6
Panicali, D.7
Sullivan, J.L.8
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29
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0027939480
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HIV-1 specific cytotoxic T lymphocyte response in healthy long-term nonprogressing seropositive persons
-
(suppl 2)
-
Harrer E, Harrer T, Buchbinder S, Mann DL, Feinberg M, Yilma T, Johnson RP, Walker BD. HIV-1 specific cytotoxic T lymphocyte response in healthy long-term nonprogressing seropositive persons. (suppl 2) AIDS Res Hum Retrovirus. 10:1994;77-78.
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(1994)
AIDS Res Hum Retrovirus
, vol.10
, pp. 77-78
-
-
Harrer, E.1
Harrer, T.2
Buchbinder, S.3
Mann, D.L.4
Feinberg, M.5
Yilma, T.6
Johnson, R.P.7
Walker, B.D.8
-
30
-
-
0029116868
-
High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T lymphocyte activity and low viral load are associated with lack of disease in HIV-1 infected long-term nonprogressors
-
of outstanding interest. A study that succeeds in correlating low viral load, strong CTL activity and slow disease progression.
-
Rinaldo C, Huang XL, Fan ZF, Ding M, Beltz L, Logar A, Panicali D, Mazzara G, Liebman J, Cottril M. High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T lymphocyte activity and low viral load are associated with lack of disease in HIV-1 infected long-term nonprogressors. of outstanding interest J Virol. 69:1995;5838-5842 A study that succeeds in correlating low viral load, strong CTL activity and slow disease progression.
-
(1995)
J Virol
, vol.69
, pp. 5838-5842
-
-
Rinaldo, C.1
Huang, X.L.2
Fan, Z.F.3
Ding, M.4
Beltz, L.5
Logar, A.6
Panicali, D.7
Mazzara, G.8
Liebman, J.9
Cottril, M.10
-
31
-
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0029880783
-
Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection
-
of special interest. The characterization of HIV-specific CTLs in LTNPs shows that CTLs recognize multiple HIV proteins or epitopes and that a high viral load may not be required to generate a strong CTL response.
-
Harrer T, Harrer E, Kalams SA, Barbosa P, Trocha A, Johnson RP, Elbeik T, Feinberg MB, Buchbinder SP, Walker BD. Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. of special interest J Immunol. 156:1996;2616-2623 The characterization of HIV-specific CTLs in LTNPs shows that CTLs recognize multiple HIV proteins or epitopes and that a high viral load may not be required to generate a strong CTL response.
-
(1996)
J Immunol
, vol.156
, pp. 2616-2623
-
-
Harrer, T.1
Harrer, E.2
Kalams, S.A.3
Barbosa, P.4
Trocha, A.5
Johnson, R.P.6
Elbeik, T.7
Feinberg, M.B.8
Buchbinder, S.P.9
Walker, B.D.10
-
32
-
-
0029084730
-
+ lymphocyte activity
-
of outstanding interest. An extensive virological and immunological study delineating the heterogenecity among AIDS patients, nonprogressors and long-term survivors at the CTL level and defining differences between them.
-
+ lymphocyte activity. of outstanding interest J Infect Dis. 172:1995;329-339 An extensive virological and immunological study delineating the heterogenecity among AIDS patients, nonprogressors and long-term survivors at the CTL level and defining differences between them.
-
(1995)
J Infect Dis
, vol.172
, pp. 329-339
-
-
Ferbas, J.1
Kaplan, A.H.2
Hausner3
Hultin, L.E.4
Matud, J.L.5
Liu, Z.6
Panicali, D.L.7
Nerng-Ho, H.8
Detels, R.9
Giorgi, J.V.10
-
33
-
-
0006582115
-
Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection
-
of outstanding interest. A major study linking several HLA class I or class II alleles with a slow rate of disease progression in a subset of the MACS cohort. These promising results strengthen our belief in the role of immune responses in determining favourable outcomes.
-
Kaslow RA, Carrington M, Apple R, Park L, Munoz A, Saah AJ, Goedert JJ, Winkler C, OBrien SJ, Rinaldo C, et al. Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection. of outstanding interest Nat Med. 24:1996;405-411 A major study linking several HLA class I or class II alleles with a slow rate of disease progression in a subset of the MACS cohort. These promising results strengthen our belief in the role of immune responses in determining favourable outcomes.
-
(1996)
Nat Med
, vol.24
, pp. 405-411
-
-
Kaslow, R.A.1
Carrington, M.2
Apple, R.3
Park, L.4
Munoz, A.5
Saah, A.J.6
Goedert, J.J.7
Winkler, C.8
OBrien, S.J.9
Rinaldo, C.10
-
34
-
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0026746352
-
Cytotoxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus-1 infected mothers
-
Cheynier R, Langlade-Demoyen P, Marescot MR, Blanche S, Blondin G, Wain-Hobson S, Griscelli C, Vilmer E, Plata F. Cytotoxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus-1 infected mothers. Eur J Immunol. 22:1992;2211-2217.
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(1992)
Eur J Immunol
, vol.22
, pp. 2211-2217
-
-
Cheynier, R.1
Langlade-Demoyen, P.2
Marescot, M.R.3
Blanche, S.4
Blondin, G.5
Wain-Hobson, S.6
Griscelli, C.7
Vilmer, E.8
Plata, F.9
-
35
-
-
0028093432
-
Multispecific and heterogeneous recognition of the gag protein by cytotoxic T lymphocytes (CTL) from HIV-infected patients: Factors other than the MHC control the epitopic specificities
-
Buseyna F, Janvier G, Fleury B, Schmidt D, Rivière Y. Multispecific and heterogeneous recognition of the gag protein by cytotoxic T lymphocytes (CTL) from HIV-infected patients: factors other than the MHC control the epitopic specificities. Clin Exp Immunol. 97:1994;353-360.
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(1994)
Clin Exp Immunol
, vol.97
, pp. 353-360
-
-
Buseyna, F.1
Janvier, G.2
Fleury, B.3
Schmidt, D.4
Rivière, Y.5
-
36
-
-
0028815220
-
HIV-1-specific cytotoxic T lymphocyte responses in the first year of life
-
of outstanding interest. An important study of HIV-specific CTLs in children the results indicate that CTL responses were not detectable in exposed, noninfected infants.
-
Luzuriaga K, Holmes D, Hereema A, Wong J, Panicali DL, Sullivan JL. HIV-1-specific cytotoxic T lymphocyte responses in the first year of life. of outstanding interest J Immunol. 154:1995;433-443 An important study of HIV-specific CTLs in children the results indicate that CTL responses were not detectable in exposed, noninfected infants.
-
(1995)
J Immunol
, vol.154
, pp. 433-443
-
-
Luzuriaga, K.1
Holmes, D.2
Hereema, A.3
Wong, J.4
Panicali, D.L.5
Sullivan, J.L.6
-
37
-
-
0027973482
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0029875421
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Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
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Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic regions of the Human Immunodeficiency Virus 1 Nef protein
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of special interest. Some RT viral variants have been found to induce antagonistic effects by the inhibition of CTL recognition of wild-type peptides without affecting viral viability.
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Meier, U.C.1
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52
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of special interest. This study indicates that viral variant persistence is mostly transient and may create successive waves of new variants and specific CTLs.
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Haas G, Debré P, Dudoit Y, Bonduelle O, Katlama C, Maier B, Plikat U, Meyerhans A, Ihlenfeldt HG, Jung G, Autran B. Time course adaptation of HIV-1 Nef-specific CTL to epitope variations [abstract]. of special interest J Cell Biochem. 21a:1995;142 This study indicates that viral variant persistence is mostly transient and may create successive waves of new variants and specific CTLs.
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53
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Sequence constraints and recognition by CTL of an HLA-B27-restricted HIV-1 gag epitope
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of special interest. Some HIV Gag viral variants that are not recognized by specific CTLs result in reduced viral infectivity.
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Nietfield W, Bauer M, Fevrier M, Maier R, Holzwarth B, Frank R, Maier B, Riviere Y, Meyerhans A. Sequence constraints and recognition by CTL of an HLA-B27-restricted HIV-1 gag epitope. of special interest J Immunol. 1995;2188-2197 Some HIV Gag viral variants that are not recognized by specific CTLs result in reduced viral infectivity.
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Nietfield, W.1
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55
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of outstanding interest. The authors predict using a mathematical model that fluctuations in HIV viral variation and CTL responses are a function of immunodominance of viral epitopes.
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Nowak MA, May RM, Phillips RE, Rowland-Jones S, Lalloo D, McAdam S, Klenerman P, Köppe B, Sigmund K, Bangham CRM, McMichael AJ. Antigenic oscillations and shifting immunodominance in HIV-1 infections. of outstanding interest Nature. 375:1995;606-611 The authors predict using a mathematical model that fluctuations in HIV viral variation and CTL responses are a function of immunodominance of viral epitopes.
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Nowak, M.A.1
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McMichael, A.J.11
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56
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0029985351
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of outstanding interest. Additional model to suggest the impact of CTL responsiveness to and recognition of viral epitopes on viral load and disease progression in HIV-1 and HIV infections.
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Nowak MA, Bangham CR. Population dynamics of immune responses to persistent viruses. of outstanding interest Science. 272:1996;74-79 Additional model to suggest the impact of CTL responsiveness to and recognition of viral epitopes on viral load and disease progression in HIV-1 and HIV infections.
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67
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of outstanding interest. Demonstrates the presence of specific CTLs and highly diverse virus types in nonprogressors, while rapid progressors show low diversity and no specific CTLs.
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Wolinsky SM, Korber BTM, Neumann AU, Daniels M, Kunstman KJ, Whetsell AJ, Furtado MR, Cao Y, Do DD, Safrit JT, Koup RA. Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection. of outstanding interest Science. 272:1996;537-542 Demonstrates the presence of specific CTLs and highly diverse virus types in nonprogressors, while rapid progressors show low diversity and no specific CTLs.
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Science
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Wolinsky, S.M.1
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Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression
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of outstanding interest. A passive HIV-specific CTL transfer study in a single HIV progressor using expanded in vitro CTL clones. Continuing disease progression and induction of a massive escape phenomenon demostrate the limits of immune therapy based upon a clonal CTL approach and its potentially deleterious effects.
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Koenig S, Conley AJ, Brewah YA, Jones GM, Leath S, Boots LJ, Davey V, Pantaleo G, Demarest JF, Carter C, et al. Transfer of HIV-1 specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression. of outstanding interest Nat Med. 4:1995;330-336 A passive HIV-specific CTL transfer study in a single HIV progressor using expanded in vitro CTL clones. Continuing disease progression and induction of a massive escape phenomenon demostrate the limits of immune therapy based upon a clonal CTL approach and its potentially deleterious effects.
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of outstanding interest. A passive HIV-specific CTL transfer study in progressors using Gag-specific CTL clones transfected with the TK suicide gene. Transfer-induced potent TK-specific CTL activity that prompted rapid elimination of the transferred CTLs, thus demonstrating the capacity to prime new CTLs in vivo in progressors.
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Riddell ST, Elliott M, Lewinsohn DA, Gilbert MJ, Wilson L, Manley SA, Lupton SD, Overell RW, Reynolds RC, Corey L, Greenberg PD. T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. of outstanding interest Nat Med. 2:1996;216-223 A passive HIV-specific CTL transfer study in progressors using Gag-specific CTL clones transfected with the TK suicide gene. Transfer-induced potent TK-specific CTL activity that prompted rapid elimination of the transferred CTLs, thus demonstrating the capacity to prime new CTLs in vivo in progressors.
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Riddell, S.T.1
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Lieberman J, Fabry JA, Shankar P, Beckett J, Skolnik PR. Ex vivo expansion of HIV type-1 specific cytolytic T cells from HIV type 1-seropositive subjects. of outstanding interest AIDS Res Hum Retroviruses. 11:1995;257-271 Transfer of HIV-specific CTLs does not induce major side effects or negative impact on disease progression like the transfer of a single clone in [69].
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