Cytokine dysregulation and increased oxidation is prevented by dehydroepiandrosterone in mice infected with murine leukemia retrovirus

Proceedings of the Society for Experimental Biology and Medicine

Volumn 216, Issue 3, 1997, Pages 386-391

  Araghi Niknam, Mohsen ^a   Zhang, Zhen ^a   Jiang, Shuguang ^a   Call, Omar ^a   Eskelson, Cleamond D ^b   Watson, Ronald R ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 6; PRASTERONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG SCREENING; FEMALE; HELPER CELL; HORMONE ACTION; MOUSE; MURINE LEUKEMIA; MURINE LEUKEMIA VIRUS; NONHUMAN; ORAL DRUG ADMINISTRATION; OXIDATION; RETROVIRUS INFECTION;

ANIMALIA; MURINAE; MURINE LEUKEMIA VIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0030732570     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.3181/00379727-216-44186     Document Type: Article

References (38)

1. Watts RR, Hulls A, Araghi-Niknam M, Chung S. Dehydroepiandrosterone and diseases of aging. Drugs Aging 9:272-291, 1996.
2. Yen SS, Morals AJ, Charm O. Replacement of DHEA in aging men and women. Potential remedial effects. Ann N Y Acad Sci 774:128-142, 1995.
3. Suzuki T, Suzuki N, Engleman EG, Minzushima Y, Sakane T. Low serum levels of dehydroepiandrosterone may cause deficient IL-2 production by lymphocytes in patients with systemic lupus erythromatosus. Clin Exp Immunol 99:251-255, 1995.
4. Aragno M, Tamagno E, Bocuzzi G, Brignardello E, Pizzini A, Danni O. DHEA pretreatment protects rats against the pro-oxidant and necrogenic effects of carbon tetrachloride. Biochem Pharmacol 46:1689-1694, 1993.
5. Liang B, Chung S, Araghi-Niknam M, Lane L. Vitamins and immunomodulation in AIDS. Nutr Sci 12:1-7, 1996.
6. Watson RR, Ed. Nutrition and AIDS. Boca Raton, FL: CRC Press, pp1-275, 1994.
7. Watson RR. Murine models for acquired deficiency syndrome. Life Sci 44:i-xii, 1989.
8. Araghi-Niknam M, Liang B, Zhen Zhang, Watson RR. Maintenance of immune dysfunction during murine retrovirus infection in old mice by DHEA. Immunology 90:344-349, 1997.
9. Raheja RK, Kaur C, Singh A, Bhatia IS. New calorimetric method for the quantitative estimation of phospholipid without acid digestion. J Lipid Res 14:695-697, 1973.
10. Zak B. Total and free cholesterol. In: Meitid S, Ed. Standards of Clinical Chemistry. New York: Academic Press, Vol 5:79-99, 1965.
11. Dugan RE, Frigero NA, Siebrt JM. Fluorometric determination of vitamin A and its derivative with trifluoroacetic acid. Anal Chem 36:114-117, 1964.
12. Watson RR, Wang JY, Dehghanpisheh K, Haung D, Wood S, Liang B, Marchelonis JJ. T cell receptor Vβ complementarity determining region 1 peptides administration moderates immune dysregulation induced by murine retrovirus infection. J Immunol 155:2282-2291, 1995.
13. Laudat A, Blum L, Guechot J, Picard O, Cabane J. Changes in systemic gonadal and adrenal steroids in asymptomatic human immunodeficiency virus-infected men: Relationship with the CD4 cell counts. Eur J Endocrinol 133:418-424, 1995.
14. Daynes RA, Dudley A, Araeno AB. Regulation of murine lymphokine production in vivo. II. Dehydroepiandrosterone is a natural enhancer of IL-2 synthesis by helper T cells. Eur J Immunol 20:793-802, 1990.
15. Kanagawa O, Vaupel BA, Gayama S, Koehler G, Kopf M. Resistance of mice deficient in IL-4 to retrovirus-induced immunodeficiency syndrome (MAIDS). Science 262:175-176, 1993.
16. Poli G, Fauci AS. Role of cytokines in the pathogenesis of human immunodeficiency virus infection. In: Aggarwal BB, Puri RK, Eds. Human Cytokines: Their Role in Disease and Therapy. Cambridge, MA: Blackwell Science, pp421-150, 1995.
17. Liang B, Zhang Z, Araghi-Niknam M, Eskelson C, Watson RR. Prevention of retrovirus induced aberrant cytokine secretion, excessive lipid peroxidation, and tissue vitamin E deficiency by T cell receptor peptide treatments in C57BL/6 mice. Proc Soc Exp Biol Med 214:87-94, 1997.
18. Van Kooten C, Rensnink T, Arden L, Van oers R. Effects of IL-4 and IL-6 on the proliferation and differentiation of B-CLL cell. Leukemia 7:618-624, 1993.
19. Daynes RA, Araneo BA, Ershler WB, Malone C, Li GZ, Ryu SY. Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in DHEA and its sulfated derivatives. J Immunol 150:5219-5230, 1993.
20. H2 switch is a critical step in the etiology of HIV infection. Immunol Today 14:107-111, 1993.
21. Yang YJ, Schwartz A, Henderson EE. Inhibition of 3′azido-3′deoxythymidine-resistant HIV-1 infection by dehydroepiandrosterone in vitro. Biochem Biophys Res Commun 201:1424-1432, 1994.
22. Chen LH, Xi S, Cohen DA. Liver endogenous antioxidant defense in mice fed AIDS 76A diet and infected with murine AIDS. Chem Biol Interact 99:17-28, 1996.
23. Delmas-Beauvieux MC, Penchant E, Couchron A, Constans J, Sergent C, Simonoff M. The enzymatic antioxidant system in blood and glutathion status in HIV-infected patients. Am J Clin Nutr 64:101-107, 1996.
24. Favier F, Sappey C, Leclerc P, Faure P, Micoud M. Antioxidant status and lipid peroxidation in patients infected with HIV. Chem Biol Interact 91:165-180, 1994.
25. Ralston A, Lin R, Beaupartant P, Wainberg MA, Hiscott J. Regulation of human immunodeficiency virus typ.1 and cytokine gene expression in myeloid cells by NF-KB/rel transcription factors. Microbiol Rev 59:481-505, 1995.
26. Vlach J, Pitha M. Activation of human immunodeficiency virus type1 provirus in T-cell and macrophages is associated with induction of inducer-specific NF-Kβ binding proteins. Virology 187:63-72, 1992.
27. Hegner D, Platt D. Effect of essential phospholipid on the properties at ATPases of isolated rat liver plasma membrane of young and old animals. Mech Ageing Dev 4:191-211, 1975.
28. Wang Y, Liang B, Watson RR. Normalization of nutritional status by various levels of vitamin E supplementation during murine AIDS. Nutr Res 14:1375-1386, 1994.
29. Tisdale MJ. Newly identified factors that alter host metabolism in cancer cachexia. Trends Pharmacol Sci 11:473-475, 1990.
30. Pape ME, Kim KH. Effects of tumor necrosis factor on acetyl-CoA enzyme A carboxylase gene expression and pre-adipocyte differentiation. Mol Endocrinol 2:395-403, 1988.
31. Pekala PH, Price SR, Horn CA, Horn BE, Moss J, Cerami A. Selective inhibition of synthesis of enzymes for de novo fatty acid biosynthesis by an endotoxin-induced mediator from exudate cells. Proc Nat Acad Sci U S A 80:2743-2747, 1983.
32. Torti FM, Dieckamn B, Beutler B, Cerami A, Ringold GM. A macrophage factor inhibits adipocytes gene expression: An in vitro Model of Cachexia. Science 229:867-869, 1985.
33. Fiengold KR, Grunfeld C. Tumor necrosis alpha stimulates hepatic lipogenesis in the rat in vivo. J Clin Invest 80:184-190, 1987.
34. Greenfield C, Paladin MA. Tumor necrosis factor: Immunologic, anti-tumor, metabolic and cardiovascular activities. Adv Intern Med 35:45-71, 1990.
35. Garcia-Martinez C, Lopez-Soriano FJ, Argiles JM. Acute treatment with tumor necrosis factor-α induces changes in protein metabolism in rat skeletal muscle. Mol Cell Biochem 125:11-18, 1993.
36. Daynes RA, Duddley DJ, Araeno BA. Dehydroepiandrosterone enhances IL-2 synthesis by helper T cells. Eur J Immunol 61:202-211, 1990.
37. Mclauchlan JA, Serkin CD, Bakouche O. Dehydroepiandrosterone modulation of lipopolysaccharide-stimulated monocytes cytotoxicity. J Immunol 15:328-335, 1996.
38. Yang JY, Schwartz A, Henderson EE. Inhibition HIV-1 latency reactivation by dehydroepiandrosterone (DHEA) and analog of DHEA. AIDS Res Hum Retroviruses 9:747-754, 1993.