Synthesis and evaluation of hydroxyproline-derived isoprenyltransferase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 14, 1999, Pages 2095-2100

  O'Connell, Celeste E ^a   Ackermann, Karen ^a   Rowell, Cheryl A ^a   Garcia, Ana Maria ^a   Lewis, Michael D ^a   Schwartz, C Eric ^a  

^a EISAI RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; ISOPRENYLTRANSFERASE INHIBITOR; N (8 AMINO 2 BENZYL 5 ISOPROPYL 9 MERCAPTO 3,6 NONADIENOYL)METHIONINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER THERAPY; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION;

3T3 CELLS; ALKYL AND ARYL TRANSFERASES; ANIMALS; DRUG DESIGN; ENZYME INHIBITORS; HYDROXYPROLINE; INHIBITORY CONCENTRATION 50; METHIONINE; MICE; MOLECULAR MIMICRY; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033584225     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00342-X     Document Type: Article

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