Synthesis of sulfur-containing olefinic peptide mimetic farnesyl transferase inhibitors using the Nozaki-Hiyama-Kishi reaction and cuprate S(N)2' displacements

Journal of Organic Chemistry

Volumn 64, Issue 1, 1999, Pages 242-251

  Yang, Hu ^a   Sheng, Xiaoning C ^a   Harrington, Edmund M ^a   Ackermann, Karen ^a   Garcia, Ana Maria ^a   Lewis, Michael D ^a  

^a EISAI RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (PHENYLMETHYL) 5 ISOPROPYL 8 AMINO 9 MERCAPTO 2,6 NONADIENYLMETHIONINE; ALKENE DERIVATIVE; N (8 AMINO 2 BENZYL 5 ISOPROPYL 9 MERCAPTO 3,6 NONADIENOYL)METHIONINE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; DIASTEREOISOMER; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SPECIFICITY; HYDROPHOBICITY; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

EID: 0033534699     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo981892c     Document Type: Article

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