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Volumn 100, Issue 7, 1997, Pages 1894-1901

Evidence that calcineurin is rate-limiting for primary human lymphocyte activation

Author keywords

Calcineurin; Cyclosporine; Immunosuppression; Lymphocytes; Signal transduction

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; MESSENGER RNA; NUCLEAR FACTOR;

EID: 0030931934     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119719     Document Type: Article
Times cited : (77)

References (60)
  • 1
    • 0027071861 scopus 로고
    • Solution structure of cyclosporin A and a nonimmunosuppressive analog bound to fully deuterated cyclophilin
    • Hsu, V.L., and I.M. Armitage. 1992. Solution structure of cyclosporin A and a nonimmunosuppressive analog bound to fully deuterated cyclophilin. Biochemistry. 31:12778-12784.
    • (1992) Biochemistry , vol.31 , pp. 12778-12784
    • Hsu, V.L.1    Armitage, I.M.2
  • 4
    • 0026643141 scopus 로고
    • Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
    • Clipstone, N.A., and G.R. Crabtree. 1992. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature (Lond.). 357:695-697.
    • (1992) Nature (Lond.) , vol.357 , pp. 695-697
    • Clipstone, N.A.1    Crabtree, G.R.2
  • 6
    • 0026575932 scopus 로고
    • The mechanism of action of cyclosporin A and FK506
    • Schreiber, S.L., and G.R. Crabtree. 1992. The mechanism of action of cyclosporin A and FK506. Immunol. Today. 13:136-142.
    • (1992) Immunol. Today , vol.13 , pp. 136-142
    • Schreiber, S.L.1    Crabtree, G.R.2
  • 7
    • 0024472603 scopus 로고
    • A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase
    • Harding, M.W., A. Galat, D.E. Uehling, and S.L. Schreiber. 1989. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature (Lond.). 341:758-760.
    • (1989) Nature (Lond.) , vol.341 , pp. 758-760
    • Harding, M.W.1    Galat, A.2    Uehling, D.E.3    Schreiber, S.L.4
  • 8
    • 0024315353 scopus 로고
    • Inhibition of T-lymphocyte activation by the immunosuppressive drug FK-506
    • Kay, J.E., C.R. Benzie, M.R. Goodier, C.J. Wick, and S.E.A. Doe. 1989. Inhibition of T-lymphocyte activation by the immunosuppressive drug FK-506. Immunology. 67:473-477.
    • (1989) Immunology , vol.67 , pp. 473-477
    • Kay, J.E.1    Benzie, C.R.2    Goodier, M.R.3    Wick, C.J.4    Doe, S.E.A.5
  • 13
    • 0027400610 scopus 로고
    • Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes
    • Ullman, K.S., J.P. Northrop, A. Admon, and G.R. Crabtree. 1993. Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes. Genes Drv. 7:188-196.
    • (1993) Genes Drv. , vol.7 , pp. 188-196
    • Ullman, K.S.1    Northrop, J.P.2    Admon, A.3    Crabtree, G.R.4
  • 14
    • 0027936441 scopus 로고
    • AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes
    • Rincón, M., and R.A. Flavell. 1994. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO (Eur. Mol. Biol. Organ.) J. 13:4370-4381.
    • (1994) EMBO (Eur. Mol. Biol. Organ.) J. , vol.13 , pp. 4370-4381
    • Rincón, M.1    Flavell, R.A.2
  • 15
    • 0028291525 scopus 로고
    • JNK is involved in signal integration during costimulation of T lymphocytes
    • Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell. 77:727-736.
    • (1994) Cell , vol.77 , pp. 727-736
    • Su, B.1    Jacinto, E.2    Hibi, M.3    Kallunki, T.4    Karin, M.5    Ben-Neriah, Y.6
  • 16
    • 0030589362 scopus 로고    scopus 로고
    • 2+ influx. Functional synergy between Raf and calcineurin
    • 2+ influx. Functional synergy between Raf and calcineurin. J. Immunol. 157:5277-5283.
    • (1996) J. Immunol. , vol.157 , pp. 5277-5283
    • Kanno, T.1    Siebenlist, D.2
  • 18
    • 0028245317 scopus 로고
    • NF-AT-AP-1 and Rel-bZIP: Hybrid vigor and binding under the influence
    • Nolan, G.P. 1994. NF-AT-AP-1 and Rel-bZIP: hybrid vigor and binding under the influence. Cell. 77:795-798.
    • (1994) Cell , vol.77 , pp. 795-798
    • Nolan, G.P.1
  • 19
    • 0027331410 scopus 로고
    • ras and calcineurin synergize to regulate the nuclear factor of activated T cells
    • ras and calcineurin synergize to regulate the nuclear factor of activated T cells. J. Exp. Med. 178:1517-1522.
    • (1993) J. Exp. Med. , vol.178 , pp. 1517-1522
    • Woodrow, M.1    Clipstone, N.A.2    Cantrell, D.3
  • 20
    • 0028936711 scopus 로고
    • NFATp, a cyclosplorin-sensitive transcription factor implicated in cytokine gene induction
    • Rao, A. 1995. NFATp, a cyclosplorin-sensitive transcription factor implicated in cytokine gene induction. J. Leukocyte Biol. 57:536-542.
    • (1995) J. Leukocyte Biol. , vol.57 , pp. 536-542
    • Rao, A.1
  • 22
    • 0026632557 scopus 로고
    • FK-506 and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
    • O'Keefe, S.J., J. Tamura, R.L. Kincaid, M.J. Tocci, and E.A. O'Neill. 1992. FK-506 and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature (Lond.). 357:692-694.
    • (1992) Nature (Lond.) , vol.357 , pp. 692-694
    • O'Keefe, S.J.1    Tamura, J.2    Kincaid, R.L.3    Tocci, M.J.4    O'Neill, E.A.5
  • 25
    • 0029028666 scopus 로고
    • Calcineurin activity is only partially inhibited in leukocytes of cyclosporine-treated patients
    • Batiuk, T.D., F. Pazderka, and P.F. Halloran. 1995. Calcineurin activity is only partially inhibited in leukocytes of cyclosporine-treated patients. Transplantation (Baltimore). 59:1400-1404.
    • (1995) Transplantation (Baltimore) , vol.59 , pp. 1400-1404
    • Batiuk, T.D.1    Pazderka, F.2    Halloran, P.F.3
  • 26
    • 0027985339 scopus 로고
    • Inhibition of calcineurin phosphatase activity in adult bone marrow transplant patients treated with cyclosporine A
    • Pai, S.Y., D.A. Fruman, T. Leong, D. Neuberg, T.G. Rosano, C. McGarigle, J.H. Antin, and B.E. Bierer. 1994. Inhibition of calcineurin phosphatase activity in adult bone marrow transplant patients treated with cyclosporine A. Blood 84:3974-3979.
    • (1994) Blood , vol.84 , pp. 3974-3979
    • Pai, S.Y.1    Fruman, D.A.2    Leong, T.3    Neuberg, D.4    Rosano, T.G.5    McGarigle, C.6    Antin, J.H.7    Bierer, B.E.8
  • 27
    • 0029122765 scopus 로고
    • Cyclosporine inhibition of calcineurin activity in human leukocytes in vivo is rapidly reversible
    • Batiuk, T.D., F. Pazderka, J. Enns, L. DeCastro, and P.F. Halloran. 1995. Cyclosporine inhibition of calcineurin activity in human leukocytes in vivo is rapidly reversible. J. Clin. Invest. 96:1254-1260.
    • (1995) J. Clin. Invest. , vol.96 , pp. 1254-1260
    • Batiuk, T.D.1    Pazderka, F.2    Enns, J.3    DeCastro, L.4    Halloran, P.F.5
  • 30
    • 0026503434 scopus 로고
    • Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A
    • Fruman, D.A., C.B. Klee, B.E. Bierer, and S.J. Burakoff. 1992. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A. Proc. Natl. Acad. Sci. USA. 89:3686-3690.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 3686-3690
    • Fruman, D.A.1    Klee, C.B.2    Bierer, B.E.3    Burakoff, S.J.4
  • 31
    • 0030049160 scopus 로고    scopus 로고
    • Cyclosporine inhibition of leukocyte calcineurin is much less in whole blood than in culture medium
    • Batiuk, T.D., F. Pazderka, J. Enns, L. DeCastro, and P.F. Halloran. 1996. Cyclosporine inhibition of leukocyte calcineurin is much less in whole blood than in culture medium. Transplantation (Baltimore). 61:158-161.
    • (1996) Transplantation (Baltimore) , vol.61 , pp. 158-161
    • Batiuk, T.D.1    Pazderka, F.2    Enns, J.3    DeCastro, L.4    Halloran, P.F.5
  • 32
    • 0026726758 scopus 로고
    • Effects of cyclosporin A and PK506 on Fcγ receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: Resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12
    • Kaye, R.E., D.A. Fruman, B.E. Bierer, M.W. Albers, L.D. Zydowsky, S.I. Ho, Y.J. Jin, M.C. Castells, S.L. Schreiber, C.T. Walsh, et al. 1992. Effects of cyclosporin A and PK506 on Fcγ receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12. Proc. Natl. Acad. Sci. USA. 89:8542-8546.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8542-8546
    • Kaye, R.E.1    Fruman, D.A.2    Bierer, B.E.3    Albers, M.W.4    Zydowsky, L.D.5    Ho, S.I.6    Jin, Y.J.7    Castells, M.C.8    Schreiber, S.L.9    Walsh, C.T.10
  • 33
    • 0029870950 scopus 로고    scopus 로고
    • Identification of a calcium inducible, cyclosporine-sensitive element in the IFN-γ promoter that is a potential NFAT binding site
    • Campbell, P.M., J. Pimm, V. Ramassar, and P.F. Halloran. 1996. Identification of a calcium inducible, cyclosporine-sensitive element in the IFN-γ promoter that is a potential NFAT binding site. Transplantation (Baltimore). 61: 933-939.
    • (1996) Transplantation (Baltimore) , vol.61 , pp. 933-939
    • Campbell, P.M.1    Pimm, J.2    Ramassar, V.3    Halloran, P.F.4
  • 34
    • 0026552626 scopus 로고
    • An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals
    • 33a. Abe, E., R. De Waal Malefyt, I. Matsuda, K. Arai, and N. Arai. 1992. An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals. Proc. Natl. Acad. Sci. USA. 89:2864-2868.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 2864-2868
    • Abe, E.1    De Waal Malefyt, R.2    Matsuda, I.3    Arai, K.4    Arai, N.5
  • 36
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 37
    • 0019061278 scopus 로고
    • Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose
    • Thomas, P.S. 1980. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. USA. 77:5201-5205.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 5201-5205
    • Thomas, P.S.1
  • 38
    • 0030011176 scopus 로고    scopus 로고
    • The functional consequences of partial calcineurin inhibition in human peripheral blood mononuclear leucocytes
    • Pazderka, F., J. Enns, T.D. Batiuk, and P.F. Halloran. 1996. The functional consequences of partial calcineurin inhibition in human peripheral blood mononuclear leucocytes. Transpl. Immunol. 4:23-31.
    • (1996) Transpl. Immunol. , vol.4 , pp. 23-31
    • Pazderka, F.1    Enns, J.2    Batiuk, T.D.3    Halloran, P.F.4
  • 39
    • 0024353079 scopus 로고
    • Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann, T.R., and R.L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol. 10:145-173.
    • (1989) Ann. Rev. Immunol. , vol.10 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 40
    • 0029928417 scopus 로고    scopus 로고
    • The expanding universe of T-cell subsets: Th1, Th2 and more
    • Mosmann, T.R., and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today. 17:138-146.
    • (1996) Immunol. Today , vol.17 , pp. 138-146
    • Mosmann, T.R.1    Sad, S.2
  • 41
    • 0028982517 scopus 로고
    • Th1 and Th2 subsets: Paradigms lost?
    • Kelso, A. 1995. Th1 and Th2 subsets: paradigms lost? Immunol. Today. 16:374-379.
    • (1995) Immunol. Today , vol.16 , pp. 374-379
    • Kelso, A.1
  • 42
    • 0028069577 scopus 로고
    • Severe combined immunodeficiency, interleukin-2 (IL-2), and the IL-2 receptor: Experiments of nature continue to point the way
    • Voss, S.D., R. Hong, and P.M. Sondel. 1994. Severe combined immunodeficiency, interleukin-2 (IL-2), and the IL-2 receptor: experiments of nature continue to point the way. Blood. 83:626-635.
    • (1994) Blood , vol.83 , pp. 626-635
    • Voss, S.D.1    Hong, R.2    Sondel, P.M.3
  • 45
    • 0028292001 scopus 로고
    • Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
    • Elder, M.E., D. Lin, J. Clever, A.C. Chan, T.J. Hope, A. Weiss, and T.G. Parslow. 1994. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science (Wash. DC). 264:1596-1599.
    • (1994) Science (Wash. DC) , vol.264 , pp. 1596-1599
    • Elder, M.E.1    Lin, D.2    Clever, J.3    Chan, A.C.4    Hope, T.J.5    Weiss, A.6    Parslow, T.G.7
  • 53
    • 0029761681 scopus 로고    scopus 로고
    • Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4
    • Shibasaki, F., E.R. Price, D. Milan, and F. McKeon. 1996. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature (Lond.). 382:370-373.
    • (1996) Nature (Lond.) , vol.382 , pp. 370-373
    • Shibasaki, F.1    Price, E.R.2    Milan, D.3    McKeon, F.4
  • 54
    • 0342688448 scopus 로고
    • Side effects (with emphasis on renal dysfunction) and recommendations for use
    • R. Schindler, editor. Springer-Verlag, Berlin/Heidelberg
    • von Graffenried, B., and W.B. Harrison. 1993. Side effects (with emphasis on renal dysfunction) and recommendations for use. In Ciclosporin in Autoimmune Diseases. R. Schindler, editor. Springer-Verlag, Berlin/Heidelberg. 60-73.
    • (1993) Ciclosporin in Autoimmune Diseases , pp. 60-73
    • Von Graffenried, B.1    Harrison, W.B.2
  • 55
    • 0027027651 scopus 로고
    • Rejection episodes
    • P.I. Terasaki and J.M. Cecka, editors. UCLA Tissue Typing Laboratory, Los Angeles
    • Koyama, H., and J.M. Cecka. 1992. Rejection episodes. In Clinical Transplants. P.I. Terasaki and J.M. Cecka, editors. UCLA Tissue Typing Laboratory, Los Angeles. 391-404.
    • (1992) Clinical Transplants , pp. 391-404
    • Koyama, H.1    Cecka, J.M.2
  • 57
  • 58
    • 0024976004 scopus 로고
    • Cyclosporine
    • Kahan, B.D. 1989. Cyclosporine. N. Engl. J. Med. 321:1725-1738.
    • (1989) N. Engl. J. Med. , vol.321 , pp. 1725-1738
    • Kahan, B.D.1
  • 59
    • 0026636583 scopus 로고
    • Cyclosporine therapy for autoimmune disease
    • Fathman, C.G., and B.D. Myers. 1992. Cyclosporine therapy for autoimmune disease. N. Engl. J. Med. 326:1693-1695.
    • (1992) N. Engl. J. Med. , vol.326 , pp. 1693-1695
    • Fathman, C.G.1    Myers, B.D.2
  • 60
    • 0029812955 scopus 로고    scopus 로고
    • Pharmacodynamic assessment of mycophenolic acid-induced immunosuppression in renal transplant recipients
    • Langman, L.J., D.F. LeGatt, P.F. Halloran, and R.W. Yatscoff. 1996. Pharmacodynamic assessment of mycophenolic acid-induced immunosuppression in renal transplant recipients. Transplantation (Baltimore). 62:666-672.
    • (1996) Transplantation (Baltimore) , vol.62 , pp. 666-672
    • Langman, L.J.1    Legatt, D.F.2    Halloran, P.F.3    Yatscoff, R.W.4


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