Inhibition of allorecognition by a human class II MHC-derived peptide through the induction of apoptosis

Journal of Clinical Investigation

Volumn 103, Issue 6, 1999, Pages 859-867

  Murphy, Barbara ^a   Magee, Colm C ^b   Alexander, Stephen I ^b   Waaga, Ana Maria ^b   Snoeck, Hans W ^a   Vella, John P ^b   Carpenter, Charles B ^b   Sayegh, Mohamed H ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DQ ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLOIMMUNITY; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FLOW CYTOMETRY; HUMAN; IMMUNOMODULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MIXED LYMPHOCYTE REACTION; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0033559381     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI5734     Document Type: Article

References (35)

1. Sloan-Lancaster, J., Evavold, B., and Allen, P. 1993. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature. 363:156-159.
2. Chicz, R.M., et al. 1992. Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size. Nature. 358:764-768.
3. Chicz, R.M., et al. 1993. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J. Exp. Med. 178:27-47.
4. Hunt, D.F., et al. 1992. Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad. Science. 256:1817-1820.
5. Magee, C.C., and Sayegh, M.H. 1997. Peptide-mediated immunosuppression. Curr. Opin. Immunol. 9:669-675.
6. Boytim, M.L., et al. 1998. Inhibition of cell cycle progression by a synthetic peptide corresponding to residues 65 79 of an HLA class II sequence: functional similarities but mechanistic differences with the immunosuppressive drug rapamycin. J. Immunol. 160:2215-2222.
7. Gallon, L., et al. 1995. Indirect pathway of allorecognition: the occurrence of self-restricted T cell recognition of allo-MHC peptides early in acute allograft rejection and its inhibition by conventional immunosuppression. Transplantation. 59:612-616.
8. Watschinger, B., Gallon, L., Carpenter, C.B., and Sayegh, M.H. 1994. Mechanisms of allorecognition: recognition by in vivo primed T-cells of specific major histocompatibility complex polymorphisms presented as peptides by responder antigen-presenting cells. Transplantation. 57:572-577.
9. Sayegh, M.H., et al. 1991. Effects of BWH-4 anti-CD4 monoclonal antibody on rat vascularized cardiac allografts before and after engraftment. Transplantation. 51:296-299.
10. Waaga, A.M., et al. 1997. Mechanisms of indirect allorecognition: characterization of MHC class II allopeptide-specific T helper cell clones from animals undergoing acute allograft rejection. Transplantation. 65:876-883.
11. Chen, W.J., et al. 1996. Mechanisms of indirect allorecognition: class II MHC allopeptide-specific T cell clones transfer delayed type hypersensitivity responses in vivo. Transplantation. 62:705-710.
12. Khoury, S.J., et al. 1993. Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide. J. Exp. Med. 178:559-566.
13. Khoury, S.J., et al. 1995. Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo. J. Exp. Med. 181:357-366.
14. Sayegh, M.H., and Turka, L.A. 1998. The role of T-cell costimulation in transplant rejection. N. Engl. J. Med. 338:1813-1821.
15. Turka, L.A., et al. 1992. T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. Proc. Natl. Acad. Sci. USA. 89:11102-11105.
16. Akalin, E. 1996. CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: inhibition of cell-mediated and humoral immune responses in vivo. Transplantation. 62:1942-1945.
17. Harris, P.E., Zhuoru, L., and Suciu-Foca, N. 1992. MHC class II binding of peptides derived from HLA-DRI. J. Immunol. 148:2169-2174.
18. Zavazava, N., and Kronke, M. 1996. Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes. Nat. Med. 2:1005-1010.
19. Sayegh, M.H., and Carpenter, M.H. 1996. Role of indirect allorecognition in allograft rejection. Int. Rev. Immunol. 13:221-229.
20. Eckels, D.D., Gorski, J., Rothbard, J., and Lamb, J.R. 1988. Peptide-mediated modulation of T-cell allorecognition. Proc. Natl. Acad. Sci. USA. 85:8191-8195.
21. Murphy, B., and Sayegh, M.H. 1996. Immunomodulatory function of MHC-derived peptides. Curr. Opin. Nephrol. Hypertens. 5:262-268.
22. Sayegh, M.H., and Krensky, A.M. 1996. Novel immunotherapeutic strategies using MHC derived peptides. Kidney Int. 49:S13-S20.
23. Giral, M., et al. 1997. Decreased cytotoxic activity of natural killer cells in kidney allograft recipients treated with human HLA-derived peptide. Transplantation. 63:1004-1011.
24. Krensky, A.M., and Clayberger, C. 1997. HLA-derived peptides as novel immunosuppressives. Nephrol Dial. Transplant. 12:865-868.
25. Nossner, E., et al. 1996. HLA-derived peptides which inhibit T cell function bind to members of the heat-shock protein 70 family. J. Exp. Med. 183:339-348.
26. Iyer, S., et al. 1998. Characterization and biological significance of immunosuppressive peptide D2702.75-84 (E-V) binding protein. J. Biol. Chem. 273:2692-2697.
27. Shen, X., et al. 1996. Peptides corresponding to CD4-interacting regions of murine MHC class II molecules modulate immune responses of CD4+ T lymphocytes in vitro and in vivo. J. Immunol. 157:87-100.
28. Paliakasis, K., et al. 1996. Novel structural features of the human histocompatibility molecules HLA-DQ as revealed by modeling based on the published structure of the related molecule HLA-DR. J. Struct. Biol. 117:145-163.
29. Fields, B.A., et al. 1995. Crystal structure of the V alpha domain of a T cell antigen receptor. Science. 270:1821-1824.
30. Brown, J.H., et al. 1993. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature. 364:33-39.
31. Valitutti, S., and Lanzavecchia, A. 1997. Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition. Immunol. Today. 18:299-304.
32. Mueller, D.L., and Jenkins, M.K. 1995. Molecular mechanisms underlying functional T-cell unresponsiveness. Curr. Opin. Immunol. 7:375-381.
33. Rhode, P.R., et al. 1996. Single-chain MHC class II molecules induce T cell activation and apoptosis. J. Immunol. 157:4885-4891.
34. Fields, B.A., and Mariuzza, R.A. 1996. Structure and function of the T-cell receptor: insights from X-ray crystallography. Immunol. Today. 17:330-336.
35. Skov, S., Bregenholt, S., and Claesson, M.H. 1997. MHC class I ligation of human T cells activates the ZAP70 and p56lck tyrosine kinase, leads to an alternative phenotype of the TCR/CD3 zeta chain, and induces apoptosis. J. Immunol. 158:3189-3196.