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T cell costimulatory pathways: Promising novel targets for immunosuppression and tolerance induction
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Sayegh MH, Turka LA: T cell costimulatory pathways: promising novel targets for immunosuppression and tolerance induction. J Am Soc Nephrol 1995, 6:1143-1150.
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(1995)
J Am Soc Nephrol
, vol.6
, pp. 1143-1150
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Sayegh, M.H.1
Turka, L.A.2
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47
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0027255487
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Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalotigenic peptide
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Khoury SJ, Sayegh MH, Gallon L, Hancock WW, Carpenter CB, Weiner HL: Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalotigenic peptide. J Exp Med 1993, 178:559-566.
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(1993)
J Exp Med
, vol.178
, pp. 559-566
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Khoury, S.J.1
Sayegh, M.H.2
Gallon, L.3
Hancock, W.W.4
Carpenter, C.B.5
Weiner, H.L.6
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48
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0029164864
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Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: Thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo
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Khoury SJ, Gallon L, Chen W, Betres K, Russell ME, Hancock WW, Carpenter CB, Sayegh MH, Weiner HL: Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo. J Exp Med 1995, 181:357-366. This study investigates the mechanisms of acquired thymic tolerance in an autoimmune model. The results showed that thymic dendritic-enriched cells mediate the induction of tolerance. Interaction of primed T cells with thymic dendritic-enriched cells resulted in anergy or deletion of these cells leading to antigen-specific systemic tolerance.
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(1995)
J Exp Med
, vol.181
, pp. 357-366
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Khoury, S.J.1
Gallon, L.2
Chen, W.3
Betres, K.4
Russell, M.E.5
Hancock, W.W.6
Carpenter, C.B.7
Sayegh, M.H.8
Weiner, H.L.9
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49
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0345156463
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Applicability of acquired thymic unresponsiveness in humans
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Sayegh MH: Applicability of acquired thymic unresponsiveness in humans [Editorial]. J Nephrol 1994, 7:3-4.
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(1994)
J Nephrol
, vol.7
, pp. 3-4
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Sayegh, M.H.1
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51
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0028202792
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Oral tolerance: Immunologic mechanisms and treatment of murine and human organ specific autoimmune diseases by oral administration of autoantigens
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Weiner HL, Friedman A, Miller A, Khoury SJ, Al-Sabbagh A, Santos L, Sayegh MH, Nussenblatt RB, Trentham DE, Hafler DA: Oral tolerance: immunologic mechanisms and treatment of murine and human organ specific autoimmune diseases by oral administration of autoantigens. Ann Rev Immun 1994, 12:809-837.
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(1994)
Ann Rev Immun
, vol.12
, pp. 809-837
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Weiner, H.L.1
Friedman, A.2
Miller, A.3
Khoury, S.J.4
Al-Sabbagh, A.5
Santos, L.6
Sayegh, M.H.7
Nussenblatt, R.B.8
Trentham, D.E.9
Hafler, D.A.10
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52
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0026595059
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Orally administered alloantigen down-regulates the immune response to histocompatibility antigens and prevents sensitization by skin allografts
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Sayegh MH, Zhang ZJ, Hancock WW, Kwok CA, Carpenter CB, Weiner HL: Orally administered alloantigen down-regulates the immune response to histocompatibility antigens and prevents sensitization by skin allografts. Transplantation 1992, 53:163-166.
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(1992)
Transplantation
, vol.53
, pp. 163-166
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Sayegh, M.H.1
Zhang, Z.J.2
Hancock, W.W.3
Kwok, C.A.4
Carpenter, C.B.5
Weiner, H.L.6
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53
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0027324854
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Oral but not intravenous alloantigen prevents accelerated allograft rejection by selective intragraft Th2 cell activation
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Hancock WW, Sayegh MH, Kwok CA, Weiner HL, Carpenter CB: Oral but not intravenous alloantigen prevents accelerated allograft rejection by selective intragraft Th2 cell activation. Transplantation 1993, 55:1112-1118.
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(1993)
Transplantation
, vol.55
, pp. 1112-1118
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Hancock, W.W.1
Sayegh, M.H.2
Kwok, C.A.3
Weiner, H.L.4
Carpenter, C.B.5
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54
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0026770220
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Induction of immunity and oral tolerance with polymorphic class II MHC allopeptides in the rat
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Sayegh MH, Khoury SK, Hancock WW, Weiner HL, Carpenter CB: Induction of immunity and oral tolerance with polymorphic class II MHC allopeptides in the rat Proc Natl Acad Sci U S A 1992, 89:7762-7766.
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(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 7762-7766
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Sayegh, M.H.1
Khoury, S.K.2
Hancock, W.W.3
Weiner, H.L.4
Carpenter, C.B.5
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56
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0028059264
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A synthetic peptide from the third hypervariable region of major histocompatibility complex class β II chain as a vaccine for treatment of experimental autoimmune encephalomyelitis
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s antibodies and thereby prevent the development of EAE. When given after the development of disease this peptide was shown to decrease the relapse rate.
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(1996)
Proc Natl Acad Sci U S A
, vol.91
, pp. 8005-8009
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Topham, D.1
Nag, B.2
Subhashini, A.3
Sriram, S.4
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57
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0028893272
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Inhibition of the alloimmune response with synthetic non-polymorphic class II MHC peptides
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Murphy B, Akalin E, Watschinger B, Carpenter CB, Sayegh MH: Inhibition of the alloimmune response with synthetic non-polymorphic class II MHC peptides. Transplant Proc 1995, 27:409.
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(1995)
Transplant Proc
, vol.27
, pp. 409
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Murphy, B.1
Akalin, E.2
Watschinger, B.3
Carpenter, C.B.4
Sayegh, M.H.5
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58
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8944241889
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Synthetic peptides derived from highly conserved regions of the MHC class II alpha chain immunomodulate the alloimmune response in vitro
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Murphy B, Waaga A, Carpenter C, Sayegh M: Synthetic peptides derived from highly conserved regions of the MHC class II alpha chain immunomodulate the alloimmune response in vitro [Abstract]. J Am Soc Nephrol 1995, 5:1368.
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(1995)
J Am Soc Nephrol
, vol.5
, pp. 1368
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Murphy, B.1
Waaga, A.2
Carpenter, C.3
Sayegh, M.4
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