Delivery and expression of fluid shear stress-inducible promoters to the vessel wall: Applications for cardiovascular gene therapy

Human Gene Therapy

Volumn 10, Issue 18, 1999, Pages 3031-3044

  Houston, Parul ^a   White, Brian P ^a   Campbell, Callum J ^a   Braddock, Martin ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ATHEROSCLEROSIS; BINDING SITE; CARDIOVASCULAR DISEASE; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN CELL; PERIPHERAL OCCLUSIVE ARTERY DISEASE; SHEAR STRESS;

ANIMALS; BASE SEQUENCE; CARDIOVASCULAR DISEASES; CELLS, CULTURED; DNA PRIMERS; ENDOTHELIUM, VASCULAR; GENE THERAPY; HUMANS; PROMOTER REGIONS (GENETICS); RABBITS; TRANSCRIPTION, GENETIC; TRANSFECTION;

ORYCTOLAGUS CUNICULUS;

EID: 0033544947     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950016429     Document Type: Article

References (78)

1. ANDO, J., TSUBOI, H., KORENAGA, R., TAKADA, Y., TOYAMA-SORIMACHI, N., MIYASAKA, M., and KAMIYA, A. (1995). Down-regulation of vascular adhesion molecule-1 by fluid shear stress in cultured mouse endothelial cells. Ann. N.Y. Acad. Sci. 748, 148-157.
2. ARAP, W., PASQUALINI, R., and RUOSLAHTI, E. (1998). Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 279, 377-380.
3. BOM, N., LI, W., VAN DER STEEN, A.F., LANCEE, C.T., CESPEDES, E.I., SLAGER, C.J., and DE KORTE, C.L. (1998). New developments in intravascular ultrasound imaging. Eur. J. Ultrasound 7, 9-14.
4. BRADDOCK, M., SCHWACHTGEN, J.-L., HOUSTON, P., DICKSON, M.C., LEE, M.J., and CAMPBELL, C.J. (1998). Fluid shear stress modulation of gene expression in endothelial cells. News Physiol. Sci. 13, 241-246.
5. BUDKER, V., GUREVICH, V., HAGSTROM, J.E., BORTZOV, F., and WOLFF, J.A. (1996). pH-sensitive, cationic liposomes: A new synthetic virus-like vector. Nature Biotechnol. 14, 760-764.
6. CARO, C.G., FITZ-GERALD, J.M., and SCHROTER, R.C. (1969). Arterial wall shear and distribution of early atheroma in man. Nature (London) 223, 1159-1160.
7. CARO, C.G., FITZ-GERALD, J.M., and SCHROTER, R.C. (1971). Atheroma and arterial wall shear, observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis. Proc. R. Soc. London Ser. B Biol. Sci. 177, 109-159.
8. CHANDRAN, K.B., VONESH, M.J., ROY, A., GREENFIELD, S., KANE, B., GREENE, R., and McPHERSON, D.D. (1996). Computation of vascular flow dynamics from intravascular ultrasound images. Med. Eng. Phys. 18, 295-304.
9. CHANNON, K.M., QIAN, H., YOUNGBLOOD, S.A., OLMEZ, E., SHETTY, G.A., NEPLIOUEVA, V., BLAZING, M.A., and GEORGE, S.E. (1998). Acute host-mediated endothelial injury after adenoviral gene transfer in normal rabbit arteries. Impact on trans-gene expression and endothelial function. Circ. Res. 82, 1253-1262.
10. CHIEN, S., LI, S., and SHYY, Y.J. (1998). Effects of mechanical forces on signal transduction and gene expression in endothelial cells. Hypertension 31, 162-169.
11. COX, D.A., VITA, J.A., TREASURE, C.B., FISH, R.D., ALEXANDER, R.W., GANZ, P., and SELWYN, A.P. (1989). Atheroslcerosis impairs flow-mediated dilatation of coronary arteries in humans. Circulation 80, 458-465.
12. CUI, M.Z., PARRY, G.C., OETH, P., LARSON, H., SMITH, M., HUANG, R.P., and ADAMSON, E.D., and MACKMAN, N. (1996). Transcriptioanl regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and Egr-1. J. Biol. Chem. 271, 2731-2739.
13. DAVIES, P.F. (1997). Haemodynamic influences on vascular remodelling. Transplant. Immunol. 5, 243-245.
14. DAVIES, P.F., ROBOTEWSKYJ, A., GRIEM, M.L., DULL, R.O., and POLACEK, D.C. (1992). Hemodynamic forces and vascular cell communication in arteries. Arch. Pathol. Lab. Med. 116, 1301-1306.
15. DOBRIN, P.D., LITTOY, F.N., and ENDEAN, E.D. (1989). Mechanical factors predisposing to intimal hyperplasia and medial thickening in autogenous vein grafts. Surgery 105, 393-400.
16. DZIMIRI, N., CHESTER, A.H., ALLEN, S.P., DURAN, C., and YACOUB, M.H. (1996). Vascular reactivity of arterial coronary artery bypass grafts-implications for their performance. Clin. Cardiol. 19, 165-171.
17. FRIEDMAN, M.H., HUTCHINS, G.M., BARGERON, C.B., DETERS, O.J., and MARK, F.F. (1991). Correlation between intimal thickness and fluid shear in human arteries. Atherosclerosis 39, 425-436.
18. GALLIE, D.R., and KADO, C.I. (1989). A translational enhancer derived from tobacco mosaic virus is functionally equivalent to a Shine-Dalgarno sequence. Proc. Natl. Acad. Sci. U.S.A. 86, 129-132.
19. GALLIE, D.R., SLEAT, D.E., WATTS, J.W., TURNER, P.C., and WILSON, T.M. (1988). Mutational analysis of the tobacco mosaic virus 5′-leader for altered ability to enhance translation. Nucleic Acids Res. 16, 883-893.
20. GIMBRONE, M.A., JR., NAGEL, T., and TOPPER, J.N. (1997). Biomechanical activation: An emerging paradigm in endothelial adhesion biology. J. Clin. Invest. 99, 1809-1813.
21. GLAGOV, S., ZARINS, C., GIDDENS, D.P., and KU, D.N. (1988). Hemodynamics and atherosclerosis, insights and perspectives gained from studies of human arteries. Arch. Pathol. Lab. Med. 112, 1018-1031.
22. GLAGOV, S., BASSIOUNY, H.S., GIDDENS, D.P., and ZARINS, C.K. (1995). Pathobiology of plaque modeling and complication. Surg. Clin. North Am. 75, 545-556. [Review]
23. GNASSO, A., CARALLO, C., IRACE, C., SPAGNUOLO, V., DE NOVARA, G., MATTIOLO, P.L., and PUJIA, A. (1996). Association between intima-media thickness and wall shear stress in common carotid arteries in healthy male subjects. Circulation 94, 3257-3262.
24. GOLLEDGE, J., TURNER, R.J., HARLEY, S.L., SPRINGALL, D.R., and POWELL, J.T. (1997). Circumferential deformation and shear stress induce differential responses in saphenous vein endothelium exposed to arterial flow. J. Clin. Invest. 99, 2719-2726.
25. HE, X., and KU, D.N. (1996). Pulsatile flow in the human left coronary artery bifurcation: Average conditions. J. Biomech. Eng. 118, 74-82.
26. HOUSTON, P., DICKSON, M.C., LUDBROOK, V., WHITE, B.P., SCHWACHTGEN, J.L., McVEY, J.H., MACKMAN, N., REESE, J.M., GORMAN, D.G., CAMPBELL, C.J., and BRADDOCK, M. (1999). Fluid shear stress induction of the tissue factor promoter in vitro and in vivo is mediated by Egr-1. Arterioscler. Thromb. Vasc. Biol. 19, 241-249.
27. ICHIOKA, S., SHIBATA, M., KOSAKI, K., SATO, Y., HARII, K., and KAMIYA, A. (1997). Effects of shear stress on wound-healing angiogenesis in the rabbit ear chamber. J. Surg. Res. 72, 29-35.
28. IGAWA, T., NAGAMURA, Y., OZEKI, Y., ITOH, H., and UNEMI, F. (1995). Stenosis enhances role of platelets in growth of regional thrombus and intimal wall thickneing in rat carotid arteries. Circ. Res. 77, 310-316.
29. KEOGH, M.-C., CHEN, D., LUPU, F., SCHMITT, J.F., KAKKAR, V.V., and LEMOINE, N.R. (1997). High efficiency reporter gene transtection of vascular tissue in vitro and in vivo using a cationic lipid-DNA complex. Gene Ther. 4, 162-171.
30. KHACHIGIAN, L.M., and COLLINS, T. (1997). Inducible expression of Egr-1-dependent genes. a paradigm of transcriptional activation in vascular endothelium. Circ. Res. 81, 457-461.
31. KHACHIGIAN, L.M., and COLLINS, T. (1998). Early growth response factor 1: A pleiotropic mediator of inducible gene expression. J. Mol. Med. 76, 613-616.
32. KHACHIGIAN, L.M., RESNICK, N., GIMBRONE, M.A., JR., and COLLINS, T. (1995a). Nuclear factor-κB interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress. J. Clin. Invest. 96, 1169-1175.
33. KHACHIGIAN, L.M., WILLIAMS, A.J., and COLLINS, T. (1995b). Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells. J. Biol. Chem. 270, 27679-27686.
34. KHACHIGIAN, L.M., LINDNER, V., WILLIAMS, A.J., and COLLINS, T. (1996). Egr-1-induced endothelial gene expression: A common theme in vascular injury. Science 271, 1427-1431.
35. KHACHIGIAN, L.M., ANDERSON, K.R., HALNON, N.J., GIMBRONE, M.A., JR., RESNICK, N., and COLLINS, T. (1997). Egr-1 is activated in endothelial cells exposed to fluid shear stress and interacts with a novel shear-stress-response element in the PDGF A-chain promoter. Arterioscler. Thromb. Vasc. Biol. 17, 2280-2286.
36. KRAMS, R., WENTZEL, J.J., OOMEN, J.A.F., VINKE, R., SCHUURBIERS, J.C.H., DE FEYTER, P.J., SERRUYS, P.W., and SLAGER, C.J. (1997). Evaluation of endothelial shear stress and 3D geometry as factors determining the development of atherosclerosis and remodelling in human coronary arteries in vivo. Arterioscler. Thromb. Vasc. Biol. 17, 2061-2065.
37. KU, D.N. (1997). Blood flow in arteries. Annu. Rev. Fluid Mech. 29, 399-434.
38. KU, D.N., GIDDENS, D.P., ZARINS, C.K., and GLAGOV, S. (1985). Pulsatile flow and atherosclerosis in the human carotid bifurcation: positive correlation between plaque location and low and oscillating shear stress. Arteriosclerosis 5, 293-302.
39. LAFONT, A., LOIRAND, G., PACAUD, P., VILDE, F., LEMARCHAND, P., and ESCANDE, D. (1997). Vasomotor dysfunction early after exposure of normal rabbit arteries to an adenoviral vector. Hum. Gene Ther. 8, 1033-1040.
40. LAFONT, A., DURAND, E., VILDE, F., MOREYRA, C., DRECHSEL, S., MIRSHAHI, S.S., MIRSHAHI, M., GUEROT, C., and LEMARCHAND, P. (1998). Thrombus generation after adenovirus-mediated gene transfer into atherosclerotic arteries. Hum. Gene Ther. 9, 2795-2800.
41. LAN, Q., MERCURIUS, K.O., and DAVIES, P.F. (1994). Stimulation of transcription factors NF-κB and AP1 in endothelial cells subjected to shear stress. Biochem. Biophys. Res. Commun. 201, 950-956.
42. LANGILLE, B.L., and OJHA, M. (1997). Blood flow dynamics, atherosclerosis and bypass graft failure. Trends Cardiovasc. Med. 7, 111-118.
43. LEE, Y.I., and KIM, S.J. (1996). Transcriptional repression of human insulin-like growth factor-II p4 promoter by Wilms' tumor suppressor WT1. DNA Cell Biol. 15, 99-104.
44. LIN, M.C., ALMUS-JACOBS, F., CHEN, H.H., PARRY, G.C., MACKMAN, N., SHYY, J.Y., and CHIEN, S. (1997). Shear stress induction of the tissue factor gene. J. Clin. Invest. 99, 737-744.
45. MACISAAC, A.I., THOMAS, J.D., and TOPOL, E.J. (1993). Toward the quiescent coronary plaque. J. Am. Coll. Cardiol. 22, 1228-1241.
46. MALEK, A.M., and IZUMO, S. (1994). Molecular aspects of signal transduction of shear stress in the endothelial cell. J. Hypertension 12, 989-999.
47. MALEK, A.M., JACKMAN, R., ROSENBERG, R.D., and IZUMO, S. (1994). Endothelial expression of thrombomodulin is reversibly regulated by fluid shear stress. Circ. Res. 74, 852-860.
48. MIYASHIRO, J.K., POPPA, V., and BERK, B.C. (1997). Flow-induced vascular remodeling in the rat carotid artery diminishes with age. Circ. Res. 81, 311-319.
49. MONDY, J.S., LINDNER, V., MIYASHIRO, J.K., BERK, B.C., DEAN, R.H., and GEARY, R.L. (1997). Platelet-derived growth factor ligand and receptor expression in response to altered blood flow in vivo. Circ. Res. 81, 320-327.
50. MORGAN, V.L., GRAHAM, T.P., JR., ROSELLI, R.J., and LORENZ, C.H. (1998). Alterations in pulmonary artery flow patterns and shear stress determined with three-dimensional phase-contrast magnetic resonance imaging in fontan patients. J. Thorac. Cardiovasc. Surg. 116, 294-304.
51. MORINAGA, K., OKADOMA, K., KUROKI, M., MIYAZAKI, T., MUTO, Y., and INOKUCHI, K. (1985). Effect of wall shear stress on intimal thickening of arterially transplanted autogenous veins in dogs. J. Vasc. Surg. 2, 430-433.
52. MORITA, T., YOSHIZUMI, M., KURIHARA, H., MAEMURA, K., NAGAI, R., and YAZAKI, Y. (1993). Shear stress increases heparin-binding epidermal growth factor-like growth factor mRNA levels in human vascular endothelial cells. Biochem. Biophys. Res. Commun. 197, 256-262.
53. NAGEL, T., RESNICK, N., ATKINSON, W.J., DEWEY, C.F., JR., and GIMBRONE, M.A. JR., (1994). Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells. J. Clin. Invest. 94, 885-891.
54. NEWMAN, K.D., DUNN, P.F., OWENS, J.W., SCHULICK, A.H., VIRMANI, R., SUKHOVA, G., LIBBY, P., and DICHEK, D.A. (1995). Adenovirus-medaited gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation and neointimal hyperplasia. J. Clin. Invest. 96, 2955-2965.
55. OHNO, M., COOKE, J.P., DZAU, V.J., and GIBBONS, G.H. (1995). Fluid shear stress induces transforming growth factor β1 transcription and production: Modulation by potassium channel blockade. J. Clin. Invest. 95, 1363-1369.
56. OOBOSHI, H., RIOS, C.D., CHU, Y., CHRISTENSON, S.D., FARACI, F.M., DAVIDSON, B.L., and HEISTAD, D.D. (1997). Augmented adenovirus-mediated gene transfer to atherosclerotic vessels. Arterioscler. Thromb. Vasc. Biol. 17, 1786-1792.
57. OYRE, S., RINGGAARD, S., KOZERKE, S., PAASKE, W.P., ERLANDSEN, M., BOESIGER, P., and PEDERSEN, E.M. (1998). Accurate non-invasive quantitation of blood flow, cross-sectional lumen vessel area and wall shear stress by three-dimensional paraboloid modeling of magnetic resonance imaging velocity data. J. Am. Coll. Cardiol. 32, 128-134.
58. PASQUALINI, R., and RUOSLAHTI, E. (1996). Organ targeting in vivo using phage display peptide libraries. Nature (London) 380, 364-366.
59. PATRICK, C.J., JR., and McINTIRE, L.V. (1995). Shear stress and cyclic strain modulation of gene expression in vascular endothelial cells. Blood Purif. 13, 112-124.
60. PATRICK, C.W., JR., and McINTIRE, L.V. (1996). Bioengineering contributions in vascular biology at the cellular and molecular level. Trends Cardiovasc. Med. 6, 122-129.
61. REKHTER, M.D., SIMARI, R.D., WORK, C.W., NABEL, G.J., NABEL, E.G., and GORDON, D. (1998). Gene transfer into normal and atherosclerotic human blood vessels. Circ. Res. 82, 1243-1252.
62. RESNICK, N., and GIMBRONE, M.A., JR. (1995). Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J. 9, 874-882,
63. RESNICK, N., COLLINS, T., ATKINSON, W., BONTHRON, D.T., DEWEY, C.F., JR., and GIMBRONE, M.A. JR. (1993). Platelet-derived growth factor B chain promoter contains a cis-acting shear-stress-responsive element. Proc. Natl. Acad. Sci. U.S.A. 90, 4591-4595.
64. RESNICK, N., YAHAV, H., KHACHIGIAN, L.M., COLLINS, T., ANDERSON, K.R., DEWEY, F.C., and GIMBRONE, M.A., JR. (1997). Endothelial gene regulation by laminar shear stress. In Analytical and Quantitative Cardiology. (Plenum Press, New York) pp. 155-164.
65. SATO, M., and OHSHIMA, N. (1990). Effect of wall shear rate on thrombogenesis in microvessels of the rat mesentery. Circ. Res. 66, 941-949.
66. SCHWACHTGEN, J.L., HOUSTON, P., CAMPBELL, C., SUKHATME, V., and BRADDOCK, M. (1998). Fluid shear stress activation of Egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway. J. Clin. Invest. 101, 2540-2549.
67. SHYY, J.Y., LI, Y.-S., LIN, M.-C., CHEN, W., YUAN, S., USAMI, S., and CHIEN, S. (1995). Multiple cis-elements mediate shear stress-induced gene expression. J. Biomech. 28, 1451-1457.
68. SILVERMAN, E.S., KHACHIGIAN, L.M., LINDNER, V., WILLIAMS, A.J., and COLLINS, T. (1997). Inducible PDGF A-chain transcription in smooth muscle cells is mediated by Egr-1 displacement of Sp1 and Sp3. Am. J. Physiol. 273, H1415-H1426.
69. SINGH, T.M., ABE, K.Y., SASAKI, T., ZHUANG, Y.-J., MASUDA, H., and ZARINS, C.K. (1998). Basic fibroblast growth factor expression precedes flow-induced arterial enlargment. J. Surg. Res. 77, 165-173.
70. SLEAT, D.E., GALLIE, D.R., JEFFERSON, R.A., BEVAN, M.W., TURNER, P.C., and WILSON, T.M. (1987). Characterisation of the 5′-leader sequence of tobacco mosaic virus RNA as a general enhancer of translation in vitro. Gene 60, 217-225.
71. TAKADA, Y., SHINAKI, F., KONDO, S., YAMAMOTO, S., TSUBOI, H., KORENGA, R., and ANDO, J. (1994). Fluid shear stress increases the expression of thrombomodulin by cultured human endothelial cells. Biochem. Biophys. Res. Commun. 205, 1345-1352.
72. TRAUB, O., and BERK, B.C. (1998). Laminar shear stress: Mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler. Thromb. Vasc. Biol. 18, 677-685.
73. VITA, J.A., TREASURE, C.B., GANZ, P., COX, D.A., FISH, R.D., and SELWYN, A.P. (1989). Control of shear stress in the epicardial coronary arteries of human: Impairment by atherosclerosis. J. Am. Coll. Cardiol. 14, 1193-1199.
74. WALPOLA, P.L., GOTLIEB, A.I., CYBULSKY, M.I., and LANGILLE, B.L. (1995). Expression of ICAM-1 and VCAM-1 and monocyte adherence in arteries exposed to altered shear stress. Arterioscler. Thromb. Vasc. Biol. 15, 2-10.
75. WANG, X., CHU, W., and BREEMEN, C. (1996). Potentiation of acetylcholine-induced responses in freshly isolated rabbit aortic endothelial cells. J. Vasc. Res. 33, 414-424.
76. WARD-SMITH, A.J. (1980). Internal Fluid Flow: The Fluid Dynamics of Flow in Pipes and Ducts. (Clarendon Press, Oxford).
77. WELLS, D.R., ARCHIE, J.J.P., and KLEINSTREUER, C. (1996). Effect of carotid artery geometry on the magnitude and distribution of wall shear stress gradients. J. Vasc. Surg. 23, 667-678.
78. ZARINS, C.K., GIDDENS, D.P., BHARADVAJ, B.K., SOTTIURAI, V.S., MABON, R.F., and GLAGOV, S. (1983). Carotid bifurcation atherosclerosis: Quantitative correlation of plaque localization with flow velocity profiles and wall shear stress. Circ. Res. 53, 502-514.