Gene therapy for head and neck cancer: Comparing the tumor suppressor gene p53 and a cell cycle regulator WAF1/CIP1 (p21)

Archives of Otolaryngology - Head and Neck Surgery

Volumn 122, Issue 5, 1996, Pages 489-493

  Clayman, Gary L ^a   Liu, Ta Jën ^a   Overholt, S Mark ^a   Mobley, Steven R ^a   Wang, Mary ^a   Janot, Francois ^a   Goepfert, Helmuth ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; PROTEIN P21; PROTEIN P53;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL GROWTH; CONTROLLED STUDY; CYTOMEGALOVIRUS; GENE THERAPY; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT; VIRUS RECOMBINANT;

ADENOVIRUSES, HUMAN; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELLS, CULTURED; GENE EXPRESSION REGULATION, VIRAL; GENE THERAPY; GENES, P53; GENES, TUMOR SUPPRESSOR; HEAD AND NECK NEOPLASMS; HUMANS; RECOMBINATION, GENETIC;

EID: 0029882466     PISSN: 08864470     EISSN: None     Source Type: Journal    
DOI: 10.1001/archotol.1996.01890170025006     Document Type: Article

References (11)

1. Liu T-J, Zhang WW, Taylor DL, Roth JA, Goepfert H, Clayman GL. Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Res. 1994;54:3662-3667.
2. Clayman GL, El-Naggar AK, Roth JA, et al In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma Cancer Res. 1995;55:1-6.
3. American Cancer Society Facts and Figures. Washington, DC: American Cancer Society; 1993. Publication 93-400.
4. Crystal RG, McElvaney NG, Rosenfeld MA, et al. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis Nat Genet. 1994;8:42-51.
5. Graham FL, Smiley J, Russell WC, Nairn R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol. 1977; 36.59-72.
6. 1 arrest and apoptosis. Cancer Res. 1994;54:1169-1174.
7. Clayman G, Wang SW, Nicolson GL, et al. Regulation of urokinase-type plasminogen activator expression in squamous-cell carcinoma of the oral cavity. Int J Cancer. 1993;54.73-80.
8. Sacks PG, Parnes SM, Gallick GE, et al. Establishment and characterization of two new squamous cell carcinoma cell lines derived from tumors of the head and neck. Cancer Res. 1988;48:2858-2866.
9. Zhang WW, Fang X, Mazur W, French BA, Georges RN, Roth JA. High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gen Ther. 1994; 1:1-10.
10. Clayman GL, Trapnell BC, Mittereder N, et al. Transduction of normal and malignant oral epithelium by an adenovirus vector: the effect of dose and treatment time on transduction efficiency and tissue penetration Cancer Gen Ther. 1995;2:105-111.
11. Liu T-J, El-Naggar AK, McDonnell TJ, et al Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck. Cancer Res. 1995,55:3117-3122.