Simultaneous genetic chemoprotection of normal marrow cells and genetic chemosensitization of breast cancer cells in a mouse cancer gene therapy model

Clinical Cancer Research

Volumn 3, Issue 2, 1997, Pages 281-286

  Hanania, Elie G ^a,c   Deisseroth, Albert B ^b,d  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b YALE CANCER CENTER   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; PACLITAXEL; ZINC CHLORIDE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; BREAST CANCER; CONTROLLED STUDY; DRUG SENSITIZATION; GENE THERAPY; GENETIC TRANSFECTION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BONE MARROW CELLS; CHEMOPREVENTION; DISEASE MODELS, ANIMAL; DNA, COMPLEMENTARY; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE THERAPY; HUMANS; MAMMARY NEOPLASMS, ANIMAL; METALLOTHIONEIN; MICE; MICE, INBRED BALB C; P-GLYCOPROTEIN; PACLITAXEL; PROMOTER REGIONS (GENETICS); PROMOTER REGIONS, GENETIC; RETROVIRIDAE; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031020622     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Pastan, I., and Gottesman, M. M. Multiple drug resistance in human cancer. N. Engl. J. Med., 316: 1388-1393, 1987.
2. Gerlach, J. H., Kartner, N., Bell, D. R., and Ling, V. Multidrug, resistance. Cancer Surv., 5: 25-46, 1986.
3. Georges, E., Sharom, F. J., and Ling, V. Multiple resistance and chernosensitization: therapeutic implications for cancer chemotherapy. Adv. Pharmacol., 21: 185-220, 1990.
4. Hanania, E. G., and Deisseroth, A. B. Serial transplantation shows that early hematopoietic precursor cells are transduced by MDR-1 retroviral vector in a mouse gene therapy model. Cancer Gene Ther., 1: 21-25, 1994.
5. Hanania, E. G., Fu, S., Roninson, I., Zu, Z., Gottesman, M. M., and Deisseroth, A. B. Resistance to taxol chemotherapy produced in mouse marrow cells by safety-modified retroviruses containing a human MDR-1 transcription unit. Gene Ther., 2: 279-284, 1995.
6. Sorrentino, B. P., Brandt, S. J., Bodine, D., Gottesman, M., Pastan, I., Cline, A., and Nienhuis, A. W. Selection of drug resistant bone marrow cells in vivo after retroviral transfer of human MDR1. Science (Washington DC), 257: 99-102, 1992.
7. Podda, S., Ward, M., Himelstein, A., Richardson, C., DelaFlor-Weiss, E., Smith, L., Gottesman, M., Pastan, I., and Bank, A. Transfer and expression of the human multiple drug resistance gene into live mice. Proc. Natl. Acad. Sci. USA, 89: 9676-9680, 1992.
8. Mickisch, G. H., Licht, T., Merlino, G. T., Gottesman, M. M., and Pastan, I. Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: efficacy, potency and toxicity. Cancer Res., 51: 5417-5424, 1991.
9. Mickisch, G. H., Merlino, G. T., Galski, H., Gottesman, M. M., and Pastan, I. Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance. Proc. Natl. Acad. Sci. USA, 88: 547-551, 1991.
10. Pastan, I., Gottesman, M. M., Ueda, K., Lovelace, E., Rutherford, A. V., and Willingham, M. C. A retrovirus carrying an MDR-1 cDNA confers multidrug resistance and polarized expression of p-glycoprotein in MDCK cells. Proc. Natl. Acad. Sci. USA, 55: 4486-4490, 1988.
11. Vogelstein, B. and Kinzler, K. W. P53 function and dysfunction. Cell, 70: 523-526, 1992.
12. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. C. P53 mutations in human cancers. Science (Washington DC), 253: 49-53, 1991.
13. Hinds, P., Finlay, C., and Levine, A. Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation. J. Virol., 63: 739-746, 1989.
14. Eliyahu, D., Michalovitz, D., Eliyahu, S., Pinhasi-Kimhi, O., and Oren, M. Wild-type p53 can inhibit oncogene-mediated focus formation. Proc. Natl. Acad. Sci. USA, 86: 8763-8767, 1989.
15. Hollstein, M., Rice, K., Greenblatt, M. S., Soussi, T., Fuchs, R., Sorlie, T., Hovig, E., Smith-Sorensen, B., Montesano, R., and Harris, C. C. Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res., 22: 3551-3555, 1994.
16. Lowe, S. W., Bodis, S., McClatchey, A., Remington, L., Ruley, H. E., Fisher, D. E., Housman, D. E., and Jacks, T. P53 status and the efficacy of cancer therapy in vivo. Science (Washington DC), 266: 807-810, 1994.
17. Lowe, S. W., Jacks, T., Housman, D. E., and Ruley, H. E. Abrogation of oncogene-associated a poptosis allows transformation of p53-deficient cells. Proc. Natl. Acad. Sci. USA, 91: 2026-2030, 1994.
18. Lowe, S. W., Ruley, H. E., Jacks, T., and Housman, D. E. P53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74: 957-967, 1993.
19. Harris, C. C., and Hollstein, M. Clinical implications of the p53 tumor-suppressor gene. N. Engl. J. Med., 329: 1318-1327, 1993.
20. Adams, L. M., Ethier, S. P., and Ullrich, R. L. Enhanced in vitro proliferation and in vivo tumorigenic potential of mammary epithelium from BALB/c mice exposed in vivo to radiation and/or 7,12 dimethylbenz[a] anthracene. Cancer Res., 47: 4425-4431, 1987.
21. Hanania, E. G., Au, W. W., Ullrich, R. L., and Papaconstantinou, J. Regulation of retino-blastoma gene expression in a mouse mammary tumor model. Cancer Gene Ther., 2: 251-261, 1995.
22. Au, W. W., Anwar, W. R., and Hanania, E. G. Chromosome and associated changes in malignant transformation of mouse mammary cells. Cancer Res. Ther. Control, 4: 109-118.1994.
23. Hanania, E. G., Au, W. W., Ullrich, R. L., and Papaconstantinou, J. The involvement of the retinoblastoma gene in a mouse mammary tumor model. Cancer Res. Ther. Control, 4: 67-76, 1994.
24. Zhang, W., Guo, X-Y., Hu, G-Y., Liu, W-B., Shay, J. W., and Deisseroth, A. B. A temperature-sensitive mutant of human p53. EMBO J., 13: 2535-2544, 1994.
25. Hu, G-Y., Liu, W-B., Hanania, E. G., Fu, S., Wang, T., and Deisseroth, A. B. Suppression of tumorigenesis by transcription units expressing the antisense E6 and E7 and messenger RNA (mRNA) for the transforming proteins of the human papilloma virus and sense mRNA for the retinoblastoma gene in cervical carcinoma cells. Cancer Gene Ther., 2: 19-32, 1995.
26. Bardeesy, N., Falkoff, D., Petruzzi, M. J., Nowak, N., Zabel, B., Adam, M., Aguiar, M. C., Grundy, P., Shows, T., and Pelletier, J. Anaplastic Wilms' tumor, a subtype displaying poor prognosis, harbours p53 gene mutations. Nat. Genet., 7: 91-97, 1994.
27. Wada, M., Bartram, C. R., Nakamura, H., Hachiya, M., Chen, D. L., Borenstein, J., Miller, C. W., Ludwig, L., Hansen-Hagge, T. E., Ludwig, W. D., et al. Analysis of p53 mutations in a large series of lymphoid hematologie malignancies of childhood. Blood, 82: 3163-3169, 1994.
28. Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., and Wyllie, A. H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature (Lond.), 362: 786-787, 1993.
29. Yonish-Rouach, E., Resnitzky, D., Lotem, J., Sachs, L., Kimchi, A., and Oren, M. Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6. Nature (Lond.), 352: 345-347, 1991.
30. Yonish-Rouach, E., Grunwald, D., Wilder, S., Kimchi, A., May, E., Lawrence, J. J., May, P., and Oren, M. P53-mediated cell death: relationship to cell cycle control. Mol. Cell. Biol., 13: 1415-1423, 1993.
31. Bonham, L., Kwok, J., Chisholm, O., and Symonds, G. Inducible transformation of fibroblasts using a metallothionein-v-myc gene construct. Oncogene, 6: 1073-1077, 1991.
32. Culotta, V. C., and Hamer, D. H. Fine mapping of a mouse metal-lothionein gene metal 14 response element. Mol. Cell. Biol., 9: 1376-1380, 1989.
33. Shaw, P., Bovey, R., Tardy, S., Sahli, R., Sordat, B., and Costa, J. Induction of apoptosis by wild-type p53 in a human colon tumorderived cell line. Proc. Natl. Acad. Sci. USA. 89: 5595-5599, 1992.