Role of p53 in Apoptosis

Advances in Pharmacology

Volumn 41, Issue C, 1997, Pages 429-460

  Canman, Christine E ^a   Kastan, Michael B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ANIMAL; APOPTOSIS; GENE THERAPY; GENETICS; IMMUNOLOGY; REVIEW;

ANIMALS; APOPTOSIS; GENE THERAPY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030630531     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)61068-6     Document Type: Article

References (241)

1. Lane D.P., and Crawford L.V. Nature 278 (1979) 261-263
2. Linzer D.I.H., and Levine A.J. Cell 17 (1979) 43-52
3. Deleo A.B., Jay G., Appells E., Dubois G.C., Law L.W., and Old L.J. Proc. Natl. Acad. Sci. USA 76 (1979) 2420-2424
4. Crawford L. Int. Rev. Exp. Pathol. 25 (1983) 1-50
5. Eliyahu D., Raz A., Gruss P., Givol D., and Oren M. Nature 312 (1984) 646-649
6. Hinds P.W., Finlay C.A., and Levine A.J. J. Virol. 63 (1989) 739-746
7. Baker S.J., Markowitz S., Fearon E.R., Willson J.K.V., and Vogelstein B. Science 249 (1990) 912-915
8. Diller L., Kassel J., Nelson C.E., Gryka M.A., Litwak G., Gebhardt M., Bressac B., Ozturk M., Baker S.J., Vogelstein B., and Friend S.J. Mol. Cell. Biol. 10 (1990) 5772-5781
9. Martinez J., Georgoff I., and Levine A.J. Genes Dev. 5 (1991) 151-159
10. Eliyahu D., Michalovicz D., Eliyahu S., Pinhasi-Kimhi O., and Oren M. Proc. Natl. Acad. Sci. USA 86 (1989) 8763 4767
11. Finlay C.A., Hinds P.W., and Levine A.J. Cell 57 (1989) 1083-1093
12. Hollstein M., Sidransky K., Vogelstein B., and Harris C.C. Science 253 (1991) 49-53
13. Kern S., Kinzler K.W., Bruskin A., Jarosz D., Friedman P., Prives C., and Vogelstein B. Science 256 (1991) 1708-1711
14. Farmer G.E., Bargonetti J., Zhu H., Friedman P., Prywes R., and Prives C. Nature 358 (1992) 83-86
15. Bargonetti J., Friedman P., Kern S.E., and Prives C. Cell 65 (1991) 1083-1091
16. Zambetti G.P., Bargonetti J., Walker K., Prives C., and Levine A.J. Genes Dev. 6 (1992) 1143-1152
17. Funk W.D., Pak D.T., Karas R.H., Wright W.E., and Shay J.W. Mol. Cell. Biol. 12 (1992) 2866-2871
18. Vogelstein B., and Kinzler K.W. Cell 70 (1992) 523-526
19. Zambetti G.P., and Levine A.J. FASEB J. 7 (1993) 855-865
20. Raycroft L., Wu H.J., and Lozano G. Science 249 (1990) 1049-1051
21. Kern S.E., Kinzler K.W., Baker S.J., Nigro J.M., Rotter V., Levine A.J., Friedman P., Prives C., and Vogelstein B. Oncogene 9 (1991) 131-136
22. Unger T., Nau M.M., Segal S., and Minna J.D. EMBO J. 11 (1992) 1383-1390
23. Kraiss S., Quaiser A., Oren M., and Montenarh M. J. Virol. 62 (1988) 4737-4744
24. Sturzbecher H.W., Brain R., Addison C., Rudge K., Remm M., Grimaldi M., Keenan E., and Jenkins J.R. Oncogene 7 (1992) 1513-1523
25. Stenger J., Mayr G., Mann K., and Tegtmeyer P. Mol. Carcinogen. 5 (1992) 102-106
26. Milner J., and Medcalf E.A. Cell 65 (1991) 765-774
27. Kern S., Pietenpol J.A., Thiagalingam S., Seymour A., Kinsler K., and Vogelstein B. Science 256 (1992) 827-830
28. Dittmer D., Zambetti G., Chu S., Teresky A.K., Moore M., Finlay C., and Levine A.J. Nature Genet. 4 (1993) 42-46
29. Momand J., Zambetti G.P., Olson D.C., George D.L., and Levine A.J. Cell 69 (1992) 1237-1245
30. Oliner J.D., Pietenpol J.A., Thiagalingam S., Gyuris J., Kinzler K.W., and Vogelstein B. Nature 362 (1993) 857-860
31. Fakharzadeh S.S., Trusko S.P., and George D.L. EMBO J. 10 (1991) 1565-1569
32. Oliner J.D., Kinzler K.W., Meltzer P., George D.L., and Vogelstein B. Nature 358 (1992) 80-83
33. Reifenberger G., Liu L., Ichimura K., Schmidt E.E., and Collins V.P. Cancer Res. 53 (1993) 2736-2739
34. Hartwell L.H., and Weinart T.A. Science 246 (1989) 629-634
35. Kastan M.B., Onyekwere O., Sidransky D., Vogelstein B., and Craig R.W. Cancer Res. 51 (1991) 6304-6311
36. Kuerbitz S.J., Plunkett B.S., Walsh W.V., and Kastan M.B. Proc. Natl. Acad. Sci. USA 89 (1992) 7491-7495
37. Kessis T.D., Slebos R.J., Nelson R.J., Kastan M.B., Plunkett B.S., Han S.M., Lorincz A.T., Hedrick L., and Cho K.R. Proc. Natl. Acad. Sci. USA 90 (1993) 3988-3992
38. Kastan M.B., Zhan Q., El-Deiry W., Carrier F., Jacks T., Walsh W.V., Plunkett B.S., Vogelstein B., and Fornace Jr. A.J. Cell 71 (1992) 587-597
39. Paules R.S., Levedakou E.N., Wilson S.J., Innes C.L., Rhodes N., Tlsty T.D., Galloway D.A., Donehower L.A., Tainsky M.A., and Kaufmann W.K. Cancer Res. 55 (1995) 1763-1773
40. Agarwal M.L., Agarwal A., Taylor W.R., and Stark G.R. Proc. Natl. Acad. Sci. USA 92 (1995) 8493-9497
41. Nelson W.G., and Kastan M.B. Mol. Cell. Biol. 14 (1994) 1815-1823
42. Zahn Q., Bae I., Kastan M.B., and Fornace Jr. A.J. Cancer Res. 54 (1994) 2755-2760
43. Kinneret S., Bar-Shira A., Gilad S., Rotman G., Ziv Y., Vanagaite L., Tagle D.A., Smith S., Uziel T., Sfez S., Ashkenazi M., Pecker I., Frydman M., Harnik R., Patanjali S.R., Simmons A., Clines G.A., Sartiel A., Gatti R.A., Chessa L., Sanal O., Lavin M.F., Jaspers N.G.J., Taylor A.M.R., Arlett C.F., Miki T., Weissman S.M., Lovett M., Collins F.S., and Shiloh Y. Science 268 (1995) 1749-1753
44. Zakian V.A. Cell 82 (1995) 685-687
45. Keith C.T., and Schreiber S.L. Science 270 (1995) 50-51
46. Khanna K.K., and Lavin M.F. Oncogene 8 (1993) 3307-3312
47. Canman C.E., Wolff A.C., Chen C.Y., Fornace Jr. A.J., and Kastan M.B. Cancer Res. 54 (1994) 5054-5058
48. Papathanasiou M.A., Kerr N.C., Robbins J.H., McBride O.W., Alamo Jr. I., Barrett S.F., Hickson I.D., and Fornace Jr. A.J. Mol. Cell. Biol. 11 (1991) 1006-1016
49. Zahn Q., Lord K.A., Alamo Jr. I., Hollander M.C., Carrier F., Ron D., Kohn K.W., Hoffman B., Liebermann D.A., and Fornace Jr. A.J. Mol. Cell. Biol. 14 (1994) 2361-2371
50. Smith M.L., Chen I.-T., Zhan Q., Bae I., Chen C.-Y., Gilmer T.M., Kastan M.B., O'Conner P.M., and Fornace Jr. A.J. Science 266 (1994) 1376-1380
51. Xiong Y., Zhang H., and Beach D. Genes Dev. 7 (1993) 1572-1583
52. Xiong Y., Hannon G.J., Zhang H., Casso D., Kobayashi R., and Beach D. Nature 366 (1993) 701-704
53. El-Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., Lin K., Mercer W.E., Kinzler K.W., and Vogelstein B. Cell 75 (1993) 817-825
54. Harper J.W., Adami G.R., Wei N., Keyomarsi K., and Elledge S.J. Cell 75 (1993) 805-816
55. Noda A., Ning Y., Vanable S.F., Pereira-Smith O.M., and Smith J.R. Exp. Cell Res. 211 (1994) 90-98
56. Sherr C.J. Cell 79 (1994) 551-555
57. Sherr C.J., and Roberts J.M. Genes Dev. 9 (1995) 1149-1163
58. Deng C., Zhang P., Harper J.W., Elledge S.J., and Leder P. Cell 82 (1995) 675-684
59. Brugarolas J., Chandrasekaran C., Gordon J.I., Beach D., Jacks T., and Hannon G. Nature 377 (1995) 552-557
60. Waldman T., Kinzler K.W., and Vogelstein B. Cancer Res. 55 (1995) 5187-5190
61. Waldman T., Lengauer C., Kinzler K.W., and Vogelstein B. Nature 381 (1996) 713-716
62. Nevins J.R. Science 258 (1992) 424-429
63. Dulic V., Kaufman W.K., Wilson S.J., Tlsty T.D., Lees E., Harper J.W., Elledge S.J., and Reed S.I. Cell 76 (1994) 1013-1023
64. El-Deiry W.S., Harper J.W., O'Connor P.M., Velculescu V.E., Canman C.E., Jackman J., Pietenpol J.A., Burrell M., Hill D.E., Wang Y., Wiman K.G., Mercer W.E., Kastan M.B., Kohn K.W., Elledge S.J., Kinzler K.W., and Vogelstein B. Cancer Res. 54 (1994) 1169-1174
65. Slebos R.J., Lee M.H., Plunkett B.S., Kessis T.D., Williams B.O., Jacks T., Hedrick L., Kastan M.B., and Cho K.R. Proc. Natl. Acad. Sci. USA 91 (1994) 5320-5324
66. Demers G.W., Foster S.A., Halbert C.L., and Galloway D.A. Proc. Natl. Acad. Sci. USA 91 (1994) 4382-4386
67. Degregori J., Kowalik T., and Nevins J.R. Mol. Cell. Biol. 15 (1995) 4215-4224
68. Degregori J., Leone G., Ohtani K., Miron A., and Nevins J.R. Genes Dev. 9 (1995) 2873-2887
69. Flores-Rozas J., Kelman Z., Dean F.B., Pan Z.-Q., Harper J.W., Elledge S.J., O'Donnel M., and Hurwitz J. Proc. Natl. Acad. Sci. USA 91 (1994) 8655-8659
70. Waga S., Hannon G.J., Beach D., and Stillman B. Nature 369 (1994) 574-578
71. Li R., Waga S., Hannon G.J., Beach D., and Stillman B. Nature 371 (1994) 534-537
72. Dutta A., Ruppert J.M., Aster J.C., and Winchester E. Nature 365 (1993) 79-82
73. Welch P.J., and Wang J.Y.J. Cell 75 (1993) 779-790
74. Welch P.J., and Wang J.Y.J. Genes Dev. 9 (1995) 31-46
75. Wech P.J., and Wang J.Y.J. Mol. Celt. Biol. 15 (1995) 5542-5551
76. Sawyers C.L., McLaughlin J., Goga A., Havlik M., and Witte O. Cell 77 (1994) 121-131
77. Goga A., Liu X., Hambuch T.M., Senechal K., Major E., Berk A.J., Witte O.N., and Sawyers C.L. Oncogene 11 (1995) 791-799
78. Kharbanda S., Ren R.B., Pandey P., Shafman T.D., Feller S.M., Weichselbaum R.R., and Kufe D.W. Nature 376 (1995) 785-788
79. Yaun Z.M., Huang Y.Y., Whang Y., Sawyers C., Weichselbaum R., Kharbanda S., and Kufe D. Nature 382 (1996) 272-274
80. Barak Y., Juven T., Haffner R., and Oren M. EMBO J. 12 (1993) 461-468
81. Otto A., and Deppert W. Oncogene 8 (1993) 2591-2603
82. Juven T., Barak Y., Zauberman A., George D.L., and Oren M. Oncogene 8 (1993) 3411-3416
83. Chen C.-Y., Oliner J.D., Zahn Q., Fornace Jr. A.J., Vogelstein B., and Kastan M.B. Proc. Natl. Acad. Sci. USA 91 (1994) 2684-2688
84. Wu X.W., Bayle J.H., Olson D., and Levine A.J. Genes Dev. 7 (1993) 1126-1132
85. Montes de Oca Luna R., Wagner D.S., and Lozano G. Nature 378 (1995) 203-206
86. Jones S.N., Roe A.E., Donehower L.A., and Bradley A. Nature 378 (1995) 206-208
87. Okada S., Altman K.I., Gerber G.B., and Okada S. Radiation Biochemistry (1970), Academic Press, New York pp. 247-285
88. Yamada T., Ohyama H., Kinja Y., and Watanabe M. Radiat. Res. 85 (1981) 544-553
89. Umansky S.R., Koro' B.A., and Nelipovich P.A. Biochim. Biophys. Acta 655 (1981) 9-17
90. Nikonova L.V., Nelipovich P.A., and Umansky S.R. Biochim. Biophys. Acta 699 (1982) 281-289
91. Arends M.J., Morris R.G., and Wyllie A.H. Am. J. Pathol. 136 (1990) 593-608
92. Duvall E., and Wyllie A.H. Immunol. Today 7 (1986) 115-119
93. Tomei L.D., and Cope F.O. Apoptosis: The Molecular Basis of Cell Death. (1991), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
94. Potten C.S. Cancer Metastasis Rev. 11 (1992) 179-195
95. Inouye M., Tamarus M., and Kamayama Y. Int. J. Radiat. Biol. 61 (1992) 669-674
96. Warters R.L. Cancer Res. 52 (1992) 883-890
97. Sellins K.S., and Cohen J.J. J. Immunol. 139 (1987) 3199-3206
98. Yonish-Rouach E., Resnitzky D., Lotem J., Sachs L., Kimchi A., and Oren M. Nature 352 (1991) 345-347
99. Shaw P., Bovey R., Tardy S., Sahli R., Sordat B., and Costa J. Proc. Natl. Acad. Sci. USA 89 (1992) 4495-4499
100. Ryan J.J., Danish R., Gottlieb C.A., and Clarke M.F. Mol. Cell. Biol. 13 (1993) 711-719
101. Wang Y., Ramqvist T., Szekely L., Axelson H., Klein G., and Wiman K.G. Cell Growth Differ. 4 (1993) 467-473
102. Ramqvist T., Magnusson K.P., Wang Y., Szekely L., Klein G., and Wiman K.G. Oncogene 8 (1993) 1495-1500
103. Yonish-Rouach E., Grunwald D., Wilder S., Kimchi A., May E., Lawrence J., May P., and Oren M. Mol. Cell. Biol. 13 (1993) 1415-1423
104. Michalovitz D., Halevy O., and Oren M. Cell 62 (1990) 671-680
105. Slichenmyer W.J., Nelson W.G., Slebos R.J., and Kastan M.B. Cancer Res. 53 (1993) 4164-4168
106. Donehower L.A., Harvey M., Slagle B.L., McArthur M.J., Montgomery Jr. C.A., Butel J.S., and Bradley A. Nature 356 (1992) 215-221
107. Lowe S.W., Schmitt E.M., Smith S.W., Osborne B.A., and Jacks T. Nature 362 (1993) 847-849
108. Clarke A.R., Purdie C.A., Harrison D.J., Morris R.G., Bird C.C., Hooper M.L., and Wyllie A.H. Nature 362 (1993) 849-852
109. Lotem J., and Sachs L. Blood 82 (1993) 1092-1096
110. Merritt A.J., Potten C.S., Kemp C.J., Hickman J.A., Balmain A., Lane D.P., and Hall P.A. Cancer Res. 54 (1994) 614-617
111. Clark A.R., Gledhill S., Hooper M.L., Bird C.C., and Wyllie A.H. Oncogene 9 (1994) 1767-1773
112. Wood K.A., and Youle R.J. J. Neurosci. 15 (1995) 5851-5857
113. Lane D.P. Nature 362 (1993) 786-787
114. Miyashita T., Krajewski S., Krafewska M., Wang H.G., Lin H.K., Liebermann D.A., Hoffman B., and Reed J.C. Oncogene 9 (1994) 1799-1805
115. Selvakumaran M., Lin H.K., Miyashita T., Wang H.G., Krafewski S., Reed J.C., Hoffman B., and Liebermann D.A. Oncogene 9 (1994) 1791-1798
116. Oltvai Z.N., Milliman C.L., and Korsmeyer S.J. Cell 74 (1993) 609-619
117. Bakhshi A., Jensen J.P., Goldman P., Wright J.J., McBride O.W., Epstein A.L., and Korsmeyer S.J. Cell 14 (1985) 889-906
118. Cleary M., and Sklar J. Proc. Natl. Acad. Sci. USA 82 (1985) 7439-7443
119. Tsujimoto Y., Cossman J., Jaffe E., and Croce C.M. Science 226 (1984) 1097-1099
120. Sentman C.L., Shutter J.R., Hockenbery D., and Korsmeyer S.J. Cell 67 (1991) 879-888
121. White E. Genes Dev. 10 (1996) 1-15
122. Yin X.M., Oltval Z.N., and Korsmeyer S.J. Nature 369 (1994) 321-323
123. Miyashita T., and Reed J.C. Cell 80 (1995) 293-299
124. Selvakumaran M., Lin H.K., Miyashita T., Wang H.G., Krajewski S., Hoffman B., and Liebermann D. Oncogene 9 (1994) 1791-1798
125. Zhan Q., Fan S., Bae I., Guillouf C., Liebermann D.A., O'Connor P.M., and Fornace Jr. A.J. Oncogene 9 (1994) 3743-3751
126. Canman C.E., Gilmer T.M., Coutts S.B., and Kastan M.B. Genes Dev. 9 (1995) 600-611
127. Knudson C.M., Tung K.S.K., Tourtellotte W.G., Brown G.A.J., and Korsmeyer S.J. Science 270 (1995) 96-99
128. Boise L.H., Gonzalez-Garcia M., Postema C.E., Ding M., Lindsten T., Turka L.A., Mao X., Nunez G., and Thompson C.B. Cell 74 (1993) 597-608
129. Kozopas K.M., Yang T., Buchan H.L., Zhou P., and Craig R.W. Proc. Natl. Acad. Sci. USA 90 (1993) 3516-3520
130. Lin E.Y., Orlofsky A., Berger M.S., and Prystowsky M.B. J. Immunol. 151 (1993) 1979-1988
131. White E., Sabbatini P., Debbas M., Wold W.S.M., Kusher D.I., and Gooding L. Mol. Cell. Biol. 12 (1992) 2570-2580
132. Sedlak T.W., Oltvai Z.N., Yang E., Wang K., Boise L.H., Thompson C.B., and Korsmeyer S. Proc. Natl. Acad. Sci. USA 92 (1995) 7834-7838
133. Sato T., Hanada M., Bodrug S., Irie S., Iwama N., Boise L.H., Thompson C.B., Golemis E., Fong L., Wang H.G., and Reed J.C. Proc. Natl. Acad. Sci. USA 91 (1994) 9238-9242
134. Chittenden T., Harrington E.A., O'Connor R., Flemington C., Lutz R.J., Evan G.I., and Guild B.C. Nature 374 (1995) 733-736
135. Klefer M.C., Brauer M.J., Powers V.C., Wu J.J., Umansky S.R., Tomei L.D., and Barr P.J. Nature 374 (1995) 736-739
136. Farrow S.N., White J.H.M., Martinou I., Raven T., Pun K.T., Grinham C.J., Martinou J.C., and Brown R. Nature 374 (1995) 731-733
137. Yang E., Zha J., Jockel J., Boise L.H., Thompson C.B., and Korsmeyer S.J. Cell 80 (1995) 285-291
138. Owen-Schaub L.B., Zhang W., Cusack J.C., Angelo L.S., Santee S.M., Fujiwara T., Roth J.A., Deisseroth A.B., Zhang W.W., Kruzel E., and Radinsky R. Mol. Cell. Biol. 15 (1995) 3032-3040
139. Nagata S., and Golstein P. Science 267 (1995) 1449-1456
140. Caellis C., Heimberg A., and Karin M. Nature 370 (1994) 220-223
141. Mack D.H., Vartikar J., Pipas J.M., and Laimins L.A. Nature 363 (1993) 281-283
142. Ginsberg D., Mechta R.F., Yaniv M., and Oren M. Proc. Natl. Acad. Sci. USA 88 (1991) 9979-9983
143. Shen Y., and Shenk T. Proc. Natl. Acad. Sci. USA 91 (1994) 8940-8944
144. Sabbatini P., Chiou S.-K., Rao L., and White E. Mol. Cell. Biol. 15 (1995) 1060-1070
145. Prives C. Cell 78 (1994) 543-546
146. Ko L.J., and Prives C. Genes Dev. 10 (1996) 1054-1072
147. Haupt Y., Rowan S., Shaulian E., Vousden K.H., and Oren M. Genes Dev. 9 (1995) 2170-2183
148. Lin J.Y., Chen J.D., Elenbaas B., and Levine A.J. Genes Dev. 8 (1994) 1235-1246
149. Thut C.J., Chen J.L., Klemm R., and Tjian R. Science 267 (1995) 100-104
150. Sabbatini P., Lin J., Levine A.J., and White E. Genes Dev. 9 (1995) 2184-2192
151. Friedberg E.C. Annu. Rev. Biochem. 65 (1996) 15-42
152. Wang X.W., Vermeulin W., Coursen J.D., Gibson M., Lupold S.E., Forrester K., Xu G., Elmore L., Yeh H., Hoeijmakers J.H.J., and Harris C.C. Genes Dev. 10 (1996) 1219-1232
153. Wang X.W., Yeh H., Shaeffer L., Roy R., Moncollin V., Egly J.-M., Wang Z., Friedberg E.C., Evans M.K., Taffe B.G., Bohr V.A., Weeda B., Hoeijmakers J.H.J., Forrester K., and Harris C.C. Nature Genet. 10 (1995) 188-195
154. Sarnow P., Ho Y.S., Williams J., and Levine A.J. Cell 28 (1982) 387-394
155. Werness B.A., Levine A.J., and Howley P.M. Science 248 (1990) 76-79
156. Mietz J.A., Unger T., Huibregtse J.M., and Howley P.M. EMBO J. 11 (1992) 5013-5020
157. Yew P.R., and Berk A.J. Nature 357 (1992) 82-85
158. Scheffner M., Werness B.A., Hulbregtse J.M., Levine A.J., and Howley P.M. Cell 63 (1990) 1129-1136
159. DeCaprio S., Ludlow J.W., Figge J., Shew J.Y., Huang C.M., Lee W.H., Marsilio E., Paucha E., and Livingston D.M. Cell 54 (1988) 275-283
160. Dyson N., Buchkovich K., Whyte P., and Harlow E. Cell 58 (1989) 249-255
161. Whyte P., Buchkovich K.J., Horowitz J.M., Friend S.H., Raybuck M., Weinberg R., and Harlow E. Nature 334 (1988) 124-129
162. Dyson N., Howley P.M., Munger K., and Harlow E. Science 243 (1989) 934-937
163. Munger K., Werness B.A., Dyson N., Phelps W.C., Harlow E., and Howley P.M. EMBO J. 8 (1989) 4099-4105
164. Whyte P., Williamson N.M., and Harlow E. Cell 56 (1989) 67-75
165. Dyson N., Guida P., Munger K., and Harlow E. J. Virol. 66 (1992) 6893-6902
166. Davies R., Hicks R., Crook T., Morris J., and Vousden K. J. Virol. 67 (1993) 2521-2528
167. Chellappan S., Hiebert S., Mudryj M., Horowitz J.M., and Nevins J.R. Cell 65 (1989) 1053-1061
168. Chellappan S., Kraus V.B., Kroger B., Munger K., Howley P.M., Phelps W.C., and Nevins J.R. Proc. Natl. Acad. Sci. USA 89 (1992) 4549-4553
169. Rao L., Debbas M., Sabbatini P., Hockenbery D., Korsmeyer S., and White E. Proc. Natl. Acad. Sa. USA 89 (1992) 7742-7746
170. Lowe S.W., and Ruley H.E. Gemne Dev. 7 (1993) 535-545
171. Debbas M., and White E. Genes Dev. 7 (1993) 546-554
172. Lowe S.W., Jacks T., Housman D.E., and Ruley H.E. Proc. Natl. Acad. Set. USA 91 (1994) 2026-2030
173. Lowe S.W., Ruley H.E., Jacks T., and Housman D.E. Cell 74 (1993) 957-967
174. Wu X., and Levine A.J. Proc. Natl. Acad. Sci. USA 91 (1994) 3602-3606
175. Qin X.-Q., Livingston D.M., Kaelin Jr. W.G., and Adams P.D. Proc. Natl. Acad. Sci. USA 91 (1994) 10918-10922
176. Jacks T., Fazeli A., Schmitt E.M., Bronson R.T., Goodell M.A., and Weinberg R.A. Nature 2359 (1992) 295-300
177. Lee E.Y., Chang C.Y., Hu N., Wang Y.C., Lai C.C., Herrup K., and Lee W.H. Nature 359 (1992) 288-294
178. Clarke A.R., Maandag E.R., van Roon M.N.M., van der Lugt M., van der Valk, Hooper M.L., Berns A., and te Riele H. Nature 359 (1992) 328-330
179. Morgenbesser S.D., Williams B.O., Jacks T., and DePinho R.A. Nature 371 (1994) 72-74
180. Pan H., and Griep A.E. Genes Dev. 8 (1994) 1285-1299
181. Howes K.A., Ransom N., Papermaster D.S., Lasudry J.G.H., Albert D.M., and Windle J.J. Genes Dev. 8 (1994) 1300-1310
182. Evan G.I., Wyllie A.H., Gilbert C.S., Littlewood T.D., Land H., Brooks M., Waters C.M., Penn L.Z., and Hancock D.C. Cell 69 (1992) 119-128
183. Askew D.S., Ashmun R.A., Simmons B.C., and Cleveland J.L. Oncogene 6 (1991) 1915-1922
184. Hermeking H., and Eick D. Science 265 (1994) 2091-2093
185. Wagner A.J., Kokontis J.M., and Hay N. Genes Dev. 8 (1994) 2817-2830
186. Sakamuro D., Eviner V., Elliott K.J., Showe L., White E., and Prendergast G.C. Oncogene 11 (1995) 2411-2418
187. Hiebert S.W., Packman G., Strom D.K., Haffner R., Oren M., Zambetti G., and Cleveland J.L. Mol. Cell. Biol. 15 (1995) 6864-6874
188. Chiou S., Rao L., and White E. Mol. Cell. Biol. 14 (1994) 2556-2563
189. Wang Y., Szedely L., Okan I., Klein G., and Wiman K.G. Oncogene 8 (1993) 3427-3431
190. Guillouf C., Grana X., Selvakumaran M., De Luca A., Giordano A., Hoffman B., and Liebermann D.A. Blood 85 (1995) 2691-2698
191. Wang Y., Okan I., Szekely L., Klein G., and Wiman K.G. Cell Growth Differ. 6 (1995) 1071-1075
192. Pietenpol J.A., Papasdopoulas N., Markowitz S., Willson J.K.V., Kinzler K.W., and Vogelstein B. Cancer Res. 54 (1994) 3714-3717
193. Sachs L., and Lotem J. In: Gregory C.D. (Ed). Apoptosis and the Immune System (1995), Wiley-Liss, New York 371-403
194. Harrington E.A., Bennett M.R., Fanidi A., and Evan G.I. EMBO J. 13 (1994) 3286-3295
195. Lin Y., and Benchimol S. Mol. Cell. Biol. 15 (1995) 6045-6054
196. Abrahamson J.L.A., Lee J.M., and Bernstein A. Mol. Cell. Biol. 15 (1995) 6953-6960
197. Collins M.K.L., Marvel J., Malde P., and Lopez-Rivas A. J. Exp. Med. 176 (1992) 1043-1051
198. Zhang J., Harmon G.J., and Beach D. Genes Dev. 8 (1994) 1750-1758
199. Polyak K., Waldman T., He T.-C., Kinzler K.W., and Vogelstein B. Genes Dev. 10 (1996) 1945-1952
200. Lin H.-J.L., Eviner V., Prendergast G.C., and White E. Mol. Cell. Biol. 15 (1995) 4536-4544
201. Harvey M., McArthur M.J., Montgomery Jr. C.A., Butel J.S., Bradley A., and Donehower L.A. Nature Gen. 5 (1993) 225-229
202. Purdie C.A., Harrison D.J., Peter A., Dobbie L., White S., Howie S.E.M., Salter D.M., Bird C.C., Wyllie A.H., Hooper M.L., and Clarke A.R. Oncogene 9 (1994) 603-609
203. McCarthy S.A., Symonds H.S., and Van Dyke T. Proc. Natl. Acad. Sci. USA 91 (1994) 3979-3983
204. Symonds H., Krall L., Remington L., Saenz-Robles M., Lowe S., Jacks T., and Van Dyke T. Cell 78 (1994) 703-711
205. Yin Y., Tainsky M.A., Bischoff F.Z., Strong L.C., and Wahl G.M. Cell 70 (1992) 937-948
206. Livingstone L.R., White A., Sprouse J., Livanos E., Jacks T., and Tlsty T.D. Cell 70 (1992) 923-935
207. White A.E., Livanos E.M., and Tlsty T.D. Genes Dev. 8 (1994) 666-677
208. Carder P., Wyllie A.H., Purdie C.A., Morris R.G., White S., Piris J., and Bird C.C. Oncogene 8 (1993) 1397-1401
209. Graeber T.G., Peterson J.F., Tsai M., Monica K., Fornace Jr. A.J., and Giaccia A.J. Mol. Cell. Biol. 14 (1994) 6264-6277
210. Graeber T.G., Osmanian C., Jacks T., Housman D.E., Koch C.J., Lowe S.W., and Giaccia A.J. Nature 379 (1996) 88-91
211. Ziegler A., Jonason A.S., Leffell D.J., Simon J.A., Sharma H.W., Kimmelman J., Remington L., Jacks T., and Brash D.E. Nature 372 (1994) 773-776
212. Lotem J., and Sachs L. Cell Growth Differ. 4 (1993) 41-47
213. Lee J.M., and Bernstein A. Proc. Natl. Acad. Sci. USA 90 (1993) 5742-5746
214. O'Connor P.M., Jackman J., Jondle D., Bhatia K., Magrath I., and Kohn K.W. Cancer Res. 53 (1993) 4776-4780
215. Fan S., El-Deiry W.S., Bae I., Freeman J., Jondle D., Bhatia K., Fornace Jr. A.J., Magrath I., Kohn K.W., and O'Connor P.M. Cancer Res. 54 (1994) 5824-5830
216. Lowe S.W., Bodis S., McClatchey A., Remington L., Ruley H.E., Fisher D.E., Housman D.E., and Jacks T. Science 266 (1994) 807-810
217. Rusch V., Klimstra D., Venkatraman E., Oliver J., Martini N., Gralla R., Kris M., and Dmitrovsky E. Cancer Res. 55 (1995) 5038-5042
218. Wattel E., Preudhomme C., Hecquet B., Vanrumbeke M., Quesnel B., Dervite I., Morel P., and Fenaux P. Blood 84 (1994) 3148-3157
219. El Royby B.S., Thomas A., Costin D., Rosenberg C.R., Potmesil M., Silber R., and Newcomb E.W. Blood 82 (1994) 3452-3459
220. Bardeesy N., Beckwith J.B., and Pelletier J. Cancer Res. 55 (1995) 215-219
221. Hsiao M.H., Yu A.L., Yeargin J., Ku D., and Haas M. Blood 83 (1994) 2922-2930
222. Diccianni M.B., Yu J., Hsiao M., Mukherjee S., Shao L.E., and Yu A.L. Blood 84 (1994) 3105-3112
223. Kaufmann S.H. Cancer Res. 49 (1989) 5870-5878
224. Gorczyca W., Gong J., Ardelt B., Traganos F., and Darzynkiewicz Z. Cancer Res. 53 (1993) 3186-3192
225. Strasser A., Harris A.W., Jacks T., and Cory S. Cell 79 (1994) 329-339
226. Tamura T., Ishihara M., Lamphier M.S., Tanaka N., Oishi I., Aizawa S., Matsuyama T., Mak T.W., Taki S., and Taniguchi T. Nature 376 (1995) 596-599
227. Tanaka N., Ishihara M., Kitagawa M., Harada H., Kimura T., Matsuyama T., Lamphier M.S., Aizawa S., Mak T.W., and Taniguche T. Cell 77 (1994) 829-839
228. Fufiwara T., Grimm E.A., Mukhopadhyay T., Cai D.W., Owen-Schaub L.B., and Roth J.A. Cancer Res. 53 (1994) 4129-4133
229. Liu T.J., Zhang W.W., Taylor D.L., Roth J.A., Goepfert H., and Clayman G.L. Cancer Res. 54 (1994) 3662-3667
230. Clayman G.L., El-Nagger A.K., Zhang W.W., Taylor D.L., Roth J.A., Goepfert H., and Lui T.J. Cancer Res. 55 (1995) 1-6
231. Lui T.J., El-Nagger A.K., McDonnell T.J., Steele K.D., Wang M., Taylor D.L., and Clayman G.L. Cancer Res. 55 (1995) 3117-3122
232. Roth J.A., Nguyen D., Lawrence D.D., Kemp B.L., Carrasco C.H., Ferson D.Z., Hong W.K., Komaki R., Lee J.J., Nesbitt J.C., Pisters K.M.W., Putman J.B., Schea R., Shin D.M., Walsh G.L., Dolormente M.M., Han C.-I., Martin F.D., Yen N., Xu K., Stephens L.C., McDonnell T.J., Mukhopadhyay T., and Cai D. Nature Med. 2 (1996) 985-991
233. Lesoon-Wood L.A., Kim W.H., Kleinman H.K., Weintraub B.D., and Mixson A.J. Hum. Gene Ther. 6 (1995) 395-405
234. Fujiwara T., Grimm E.A., Mukhopadhyay T., Zhang W.W., Owen-Schaub L.B., and Roth J.A. Cancer Res. 54 (1994) 2287-2291
235. Yang Z.-Y., Perkins N.D., Ohno T., Nabel E.G., and Nabel G.J. Nature Med. 10 (1995) 1052-1056
236. Katayose D., Wersto R., Cowan K.H., and Seth P. Cell Growth and Differ. 6 (1995) 1207-1212
237. Eastham J.A., Hall S.J., Sehgal I., Wang J., Timme T.L., Yang G., Connell-Crowley L., Elledge S.J., Zhang W.-W., Harper J.W., and Thompson T.C. Cancer Res. 55 (1995) 5151-5155
238. Sumantran V.N., Ealovega M.W., Nunez G., Clarke M.F., and Wicha M.S. Cancer Res. 55 (1995) 2507-2510
239. Clarke M.F., Apel I.J., Benedict M.A., Eipers P.G., Sumantran V., Gonzalez-Garcia M., Doedens M., Fukunaga N., Davidson B., Dick J.E., Minn A.J., Boise L.H., Thompson C.B., Wicha M., and Nunez G. Proc. Natl. Acad. Sci. USA 92 (1995) 11024-11028
240. Sachs L., and Lotem J. Blood 82 (1993) 15-21
241. Fuks Z., Persaud R.S., Alfieri A., McLoughlin M., Ehleiter D., Schwartz J.L., Seddon A.P., Cordon-Cardo C., and Haimovitz-Friedman A. Cancer Res. 54 (1994) 2582-2590