Magnitude of 5-HT(1B) and 5-HT(1A) receptor activation in guinea-pig and rat brain: Evidence from sumatriptan dimer-mediated [35S]GTPγS binding responses

Molecular Brain Research

Volumn 67, Issue 1, 1999, Pages 107-123

  Dupuis, Delphine S ^a   Perez, Michel ^a   Halazy, Serge ^a   Colpaert, Francis C ^a   Pauwels, Petrus J ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

5 HT(1A) receptor; 5 HT(1B) receptor; 35S GTP S binding and autoradiography; G protein activation; Rat and guinea pig brain; Sumatriptan dimer

Indexed keywords

2,3,6,7 TETRAHYDRO 1' METHYL 5 [[2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL) 4 BIPHENYLYL]CARBONYL]SPIRO[FURO[2,3 F]INDOLE 3,4' PIPERIDINE]; DIMER; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KETANSERIN; MONOMER; RECEPTOR SUBTYPE; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SUMATRIPTAN; 5 (NONYLOXY)TRYPTAMINE; 5-(NONYLOXY)TRYPTAMINE; DIAGNOSTIC AGENT; GUANOSINE DIPHOSPHATE; HTR1B PROTEIN, HUMAN; MEMBRANE PROTEIN; N [4 [5 [3 (2 AMINOETHYL) 1H INDOL 5 YL] 1,2,4 OXADIAZOL 3 YL]BENZYL]METHANESULFONAMIDE; OXADIAZOLE DERIVATIVE; SEROTONIN 1 RECEPTOR; SEROTONIN AGONIST; SEROTONIN RECEPTOR; SULFUR; TRYPTAMINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN; CERCOPITHECIDAE; CONTROLLED STUDY; DIMERIZATION; GUINEA PIG; HIPPOCAMPUS; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA; SUPERIOR COLLICULUS; ANIMAL; BINDING COMPETITION; BRAIN LEVEL; DRUG EFFECT; GLIOMA; HELA CELL; METABOLISM; PHYSIOLOGY; RADIOASSAY; SPRAGUE DAWLEY RAT;

ANIMALS; AUTORADIOGRAPHY; BINDING, COMPETITIVE; BRAIN CHEMISTRY; DIMERIZATION; GLIOMA; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUINEA PIGS; HELA CELLS; HUMANS; MALE; MEMBRANE PROTEINS; OXADIAZOLES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SULFUR RADIOISOTOPES; SUMATRIPTAN; TRYPTAMINES;

EID: 0033528694     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00052-2     Document Type: Article

References (52)

1. 1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits, J. Biol. Chem. 267 (1992) 8200-8206.
2. 1D receptor messenger RNA and ligand binding sites in guinea-pig brain and trigeminal ganglion: clues for function, Neuroscience 82 (1998) 469-484.
3. 1D binding sites, J. Neurochem. 58 (1992) 951-959.
4. M.M. Bradford, A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem. 72 (1976) 248-254.
5. A.G. Buzzi, M.A. Moskowitz, S.J. Peroutka, B. Byun, Further characterisation of the putative 5-HT receptor which mediates blockade of neurogenic plasma extravasion in rat dura mater, Br. J. Pharmacol. 103 (1991) 1421-1428.
6. 1A receptor in rat brain coronal sections, Abstr. Soc. Neurosci. 23 (1997) 131.
7. 35S]GTPγS binding, J. Neurochem. 70 (1998) 1258-1268.
8. 1F ligand LY334370 in guinea-pig brain sections and recombinant cell lines, Br. J. Pharmacol. 124 (1998) 283-290.
9. 1A receptor, J. Biol. Chem. 264 (1989) 14848-14852.
10. + channels, Eur. J. Pharmacol. 340 (1997) 259-266.
11. 1D receptors: a serotonin receptor population for the 1990s, Drug News Perspect. 6 (1993) 390-405.
12. 1B/1D agonist, J. Med. Chem. 39 (1996) 4920-4927.
13. 1D serotonin receptors in rat: structural and pharmacological comparison of the two cloned receptors, Mol. Cell. Neurosci. 3 (1992) 578-587.
14. E. Hazum, K.J. Chang, H.J. Leighton, W.O. Lever, O.P. Cuatrecasas, Increased biological activity of dimers of oxymorphone and enkephalin: possible role of receptor cross-linking, Biochem. Biophys. Res. Commun. 104 (1982) 347-353.
15. 2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation, J. Biol. Chem. 271 (1996) 16384-16392.
16. R. Hen, Of mice and flies: commonalities among 5-HT receptors, Trends Pharmacol. Sci. 13 (1992) 160-165.
17. D. Hoyer, D.E. Clarke, J.R. Fozard, P.R. Hartig, G.R. Martin, E.J. Mylecharane, P.R. Saxena, P.P.A. Humphrey, International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin), Pharmacol. Rev. 46 (1994) 157-203.
18. 1A sites in rat brain: in vitro binding and autoradiographic studies, J. Pharmacol. Exp. Ther. 272 (1995) 429-437.
19. K. Le Boulluec, R.J. Mattson, C.D. Mable, R.T. McGovern, H.P. Nowak, A.J. Gentile, Bivalent indoles exhibiting serotonergic binding affinity, Bioorg. Med. Chem. Lett. 5 (1995) 123-126.
20. W.S. Lee, M.A. Moskowitz, Conformationally restricted sumatriptan analogs, CP-122288 and CP-122638 exhibit enhanced potency against neurogenic inflammation in dura mater, Brain Res. 626 (1993) 303-305.
21. + current, Naunyn-Schmiedeberg's Arch. Pharmacol. 358 (1998) 608-615.
22. T.J. Luparello, Stereotaxic Atlas of the Forebrain of the Guinea-pig, S. Karger, Basel, Switzerland, 1967.
23. 1A agonists, Mol. Pharmacol. 37 (1990) 231-237.
24. 355 Asn site directed mutagenesis, Biochem. Pharmacol. 44 (1992) 1917-1920.
25. D.N. Middlemiss, M.E. Bremer, S.M. Smith, A pharmacological analysis of the 5-HT receptors mediating inhibition of 5-HT release in the guinea-pig frontal cortex, Eur. J. Pharmacol. 157 (1988) 101-107.
26. G. Milligan, Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding G-proteins, Biochem. J. 255 (1988) 1-13.
27. 1A receptors, Eur. J. Pharmacol. 307 (1996) 107-111.
28. 1B receptors, Nature 360 (1992) 161-163.
29. 1B receptors, J. Neurochem. 60 (1993) 380-383.
30. 1A receptors that are negatively coupled to adenylate cyclase in permanently transfected HeLa cells, Biochem. Pharmacol. 45 (1993) 375-383.
31. 1B receptors, Naunyn-Schmiedeberg's Arch. Pharmacol. 253 (1996) 144-156.
32. 1Dβ receptor sites in stably transfected C6 glial cells promotes cell growth, J. Neurochem. 66 (1996) 65-73.
33. 1B/D receptor ligands: an answer from GTPS binding studies with stably transfected C6-glial cell lines, Neuropharmacology 36 (1997) 499-512.
34. 1A receptor agonists in recombinant cell lines: modulation of apparent efficacy by G-protein activation state, Naunyn-Schmiedeberg's Arch. Pharmacol. 356 (1997) 551-561.
35. 1B receptor activation by sumatriptan and related agonists, Recept. Channels 5 (1998) 367-373.
36. 1B receptor, Br. J. Pharmacol. 123 (1998) 51-62.
37. G. Paxinos, C. Watson, The Rat Brain Stereotaxic Coordinates, Academic Press, New York, 1986.
38. 1B agonist, Bioorg. Med. Chem. Lett. 8 (1998) 675-680.
39. 1B/1D receptor subtypes, Biol. Med. Chem. Lett. 8 (1998) 1407-1412.
40. P.S. Portoghese, Bivalent ligands and the message-address concept in the design of selective opioid receptor antagonists, Trends Pharmacol. Sci. 10 (1989) 230-235.
41. 1A receptors to inhibitory G protein α-subunits and lack of coupling to Gsa, Biochemistry 32 (1993) 11064-11073.
42. 35S]GTPγS binding in rat brain. Br. J. Pharmacol. 120 (Proceedings Suppl.) (1997) 297pp.
43. 2-adrenoreceptor-mediated signaling, J. Biol. Chem. 273 (1998) 5109-5116.
44. 1 binding sites: a comparative autoradiographic study between rat and guinea-pig, Brain Res. 555 (1991) 295-304.
45. 35S]thio]-triphosphate binding, Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 7242-7246.
46. L.J. Sim, D.E. Selley, R. Xiao, S.R. Childers, Differences in G-protein activation by mu- and delta-opioid, and cannabinoid, receptors in rat striatum, Eur. J. Pharmacol. 307 (1996) 97-105.
47. 35S]GTPγS binding, Eur. J. Pharmacol. 320 (1997) 267-275.
48. 35S]GTPγS binding. Br. J. Pharmacol. 120 (Proceedings Suppl.) (1997) 121pp.
49. 3H] 5-carboxamidotryptamine binding sites in the guinea pig and rat brain, Eur. J. Pharmacol. 283 (1995) 31-46.
50. 35S]guanosine-5′-O-(3-thio)triphosphate binding to rodent brain sections as visualized by in vitro autoradiography, Mol. Pharmacol. 52 (1997) 623-631.
51. 1A receptor gene is sufficient for its in vitro expression, Neurosci. Res. Commun. 19 (1996) 75-82.
52. 1Dβ receptors stably expressed in murine fibroblasts: inhibition of adenylate cyclase and elevation of intracellular calcium concentrations via pertussis toxin-sensitive G proteins, Mol. Pharmacol. 44 (1993) 575-582.