Inhibitory effects of JTE-522, a novel prostaglandin H synthase-2 inhibitor, on adjuvant-induced arthritis and bone changes in rats

Inflammation Research

Volumn 47, Issue 4, 1998, Pages 187-192

  Masaki, M ^a   Matsushita, M ^a   Wakitani, K ^a  

^a JAPAN TOBACCO INC   (Japan)

Author keywords

Adjuvant arthritis; Bone change; JTE 522; Non steroidal antiinflammatory drugs (NSAIDs); Prostaglandin H synthase 2 (PGHS 2)

Indexed keywords

ANTIRHEUMATIC AGENT; DEOXYPYRIDINOLINE; INDOMETACIN; PROSTAGLANDIN SYNTHASE INHIBITOR; PYRIDINIUM DERIVATIVE; TILMACOXIB; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE METABOLISM; BONE MINERAL; CONTROLLED STUDY; MALE; NONHUMAN; OSTEOLYSIS; PAW EDEMA; RAT; STOMACH LESION; URINALYSIS; URINARY EXCRETION;

ADMINISTRATION, ORAL; AMINO ACIDS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; BENZENESULFONATES; BONE DENSITY; CYCLOOXYGENASE INHIBITORS; HINDLIMB; INDOMETHACIN; MALE; OXAZOLES; PYRIDINIUM COMPOUNDS; RATS; RATS, INBRED LEW; STOMACH;

EID: 0031943154     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110050316     Document Type: Article

References (33)

1. O'Neill GP, Ford-Hutchinson AW. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett 1993;330:156-60.
2. Moncada S, Gryglewski R, Bunting S, Vane JR. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 1976;263:663-5.
3. Whittle BJR, Higgs GA, Eakins KE, Moncada S, Vane JR. Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa. Nature 1980;284:271-3.
4. Maier JAM, Hla T, Maciag T. Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial colls. J Biol Chem 1990;265:10805-8.
5. Xie W, Chipman JG, Robertson DL, Erikson RL, Simmons DL. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 1991;88:2692-6.
6. Kujubu DA, Fletcher BS, Varnum BC, Lim RW, Herschman HR. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 1991;266: 12866-72.
7. Crofford LJ, Wilder RL, Ristimäki AP, Sano H, Remmers EF, Epps HR, et al. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues: Effects of interleukin-1β, phorbol ester, and corticosteroids. J Clin Invest 1994;93:1095-101.
8. Kang RY, Freire-Moar J, Sigal E, Chu C-Q. Expression of cyclooxygenase-2 in human and an animal model of rheumatoid arthritis. Br J Rheumatol 1996;35:711-8.
9. 2 and cyclooxygense-2. Eur J Biochem 1994;226: 125-31.
10. Seitz M, Loetscher P, Dewald B, Towbin H, Ceska M, Baggiolini M. Production of interleukin-1 receptor antagonist, inflammatory chemotactic proteins, and prostaglandin E by rheumatoid and osteoarthritic synoviocytes - regulation by 1FN-γ and IL-4. J Immunol 1994;152:2060-5.
11. Matsushita M, Masaki M, Yagi Y, Tanaka T, Wakitani K. Pharmacological profile ot JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats. Inflamm Res 1997;46:461-6.
12. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983;16:109-10.
13. Newbould BB. Chemotherapy of arthritis induced in rats by mycobacterial adjuvant. Br J Pharmacol 1963;21:127-36.
14. Jaffe M. Über den Niederschlag, welchen Pikrinsäure in normalem Harm erzugt und über eine neue Reaktion des Kreatinins. Hoppe Seylers Z Physiol Chem 1886;10:391-400.
15. Anderson GD, Hauser SD, McGarity KL, Bremer ME, Isakson PC, Gregory SA. Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. J Clin Invest 1996;97:2672-9.
16. Sano H, Hla T, Maier JAM, Crofford LJ, Case JP, Maciag T, et al. In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. J Clin Invest 1992;89:97-108.
17. Brinckerhoff CE, Coffey JW, Sullivan AC. Inflammation and collagenase production in rats with adjuvant arthritis reduced with 13-cis-retinoic acid. Science 1983;221:756-8.
18. Hayward MA, Howard GA, Neuman RG, Wood DD, Weichman BM, Van Sickle DC. Prostagladins in inflammatory bone pathology: Mechanism and therapeutic benefit of etodolac. Agents Actions 1989;26:310-8.
19. 2 in cultured neonatal mouse calvariae. Endocrinology 1994; 135:1157-64.
20. Sato T, Morita I, Sakaguchi K, Nakahama K, Smith WL, Dewitt DL, et al. Involvement of prostaglandin endoperoxide H synthase-2 in osteoclast-like cell formation induced by interleukin-1β. J Bone Min Res 1996;11:392-400.
21. Rico H, Alamo C, Revilla M, Villa LF, Alguacil LF. Effect of adjuvant-induced arthritis on bone mass in rats and its prevention hy non-steroid anti-inflammatory drugs (NSAIDs). Clin Exp Rheumatol 1992;10:595-7.
22. Hartman DA, Ochalski SJ, Carlson RP. The effects of anti-inflammatory and antiallergic drugs on the release of IL-1β and TNF-α in the human whole blood assay. Agents Actions 1993;39(Spec Conf Issue):C70-2.
23. Puseas I, Coltau M, Pasca R. Nonsteroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action. J Pharmacol Exp Ther 1996;277:1464-6.
24. Smith-Oliver T, Noel LS, Stimpson SS, Yarnall DP, Connolly KM. Elevated levels of TNF in the joints of adjuvant arthritic rats. Cytokine 1993;5:298-304.
25. DiMartino M, Wolff C, High W, Stroup G, Hoffman S, Laydon J, et al. Anti-arthritic activity of hydroxamic acid-based pseudopeptide inhibitors of matrix metalloproteinases and TNFα processing. Inflamm Res 1997;46:211-5.
26. Neidel J, Schulze M, Lindschau J. Association between degree of bone-erosion and synovial fluid-levels of tumor necrosis factor α in the knee-joints of patients with rheumatoid arthritis. Inflamm Res 1995;44:217-21.
27. Kenny AD. Role of carbonic anhydrase in bone: Partial inhibition of disuse atrophy of bone by parenteral acetazolamide. Calcif Tissue Int 1985;37:126-33.
28. Hall TJ, Higgins W, Tardif C, Chambers TJ. A comparison of the effects of inhibitors of carbonic anhydrase on osteoclastic bone resorption and purified carbonic anhydrase isozyme II. Calcif Tissue Int 1991;49:328-32.
29. Nose T, Segawa Y, Nozaki M, Tsurumi K, Fujimura H. Polymorphonuclear leukocyte responses in adjuvant arthritis rats. Eur J Pharmacol 1990;183:2247.
30. Segawa Y, Nakamura T, Aota S, Tanaka Y, Yoshida K, Tsuzuike N, et al. Changes in urinary deoxypyridinoline level and vertebral bone mass in the development of adjuvant-induced arthritis in rats. Bone 1995;17:57-62.
31. Aota S, Nakamura T, Suzuki K, Tanaka Y, Okazaki Y, Segawa Y. et al. Effects of indomethacin administration on bone turnover and bone mass in adjuvant-induced arthritis in rats. Calcif Tissue Int 1996;59:385-91.
32. Tordjman C, Lhumeau A, Pastoureau P, Meunier F. Serkiz B, Volland JP, et al. Evaluation and comparison of urinary pyridinium crosslinks in two rat models of bone loss -ovariectomy and adjuvant polyarthritis - using a new automated HPLC method. Bone Mineral 1994;26:155-67.
33. Seibel MJ, Duncan A, Robins SP. Urinary hydroxy-pyridinium crosslinks provide indices of cartilage and bone involvement in arthritic diseases. J Rheumatol 1989;16:964-70.