An approach to combinatorial library generation of galactofuranose mimics as potential inhibitors of mycobacterial cell wall biosynthesis: Synthesis of a peptidomimetic of uridine 5'-diphosphogalactofuranose (UDP-Galf)

Tetrahedron Letters

Volumn 40, Issue 49, 1999, Pages 8689-8692

  Lee, Richard E ^a,b   Smith, Martin D ^a   Pickering, Lea ^a   Fleet, George W J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Office of the Director   (United States)

Author keywords

Amide; Combinatorial chemistry; Galactofuranose; Inhibition; Transferase; Tuberculosis

Indexed keywords

AMIDE; CARBOHYDRATE; DIAMINE DERIVATIVE; DRUG ANALOG; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; URIDINE 5' DIPHOSPHOGALACTOFURANOSE; URIDINE DIPHOSPHATE SUGAR;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0033521171     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01844-4     Document Type: Article

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14. All new compounds have satisfactory microanalysis and/or high resolution mass spectrometry data.
15. 3S) 77.1 (d), 75.6 (d), 70.1 (d), 69.0 (d), 63.6 (t), 59.2 (d), 36.3 (t).
16. 3) 77.1 (d), 75.7 (d), 70.1 (d), 69.0 (d), 63.6 (t), 58.4 (d), 45.4 (t), 34.7 (q).
17. 3) 130.8 (d), 130.1 (d), 77.0 (d), 75.7 (d), 70.1 (d), 69.0 (d), 63.5 (d), 58.9 (t), 43.5 (t).
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24. 2O) 171.6 (s), 166.8 (s), 166.6 (s), 151.9 (s), 142.7 (d), 102.7 (d), 90.9 (d), 82.1 (d), 76.3 (d), 75.9 (d), 73.4 (d), 70.8 (d), 68.4 (d), 65.9 (d), 63.3 (t), 62.2 (d), 43.1 (t), 41.0 (t).
25. 2O) 174.9 (s), 166.9 (s), 166.2 (s), 143.2 (d), 103.1 (d), 91.5 (d), 82.7 (d), 76.9 (d), 76.2 (d), 73.8 (d), 71.3 (d), 68.8 (d), 66.5(d), 63.8 (t), 62.8 (d), 41.5 (t), 37.1 (t), 35.8 (t).
26. This work has been supported by Glaxo Wellcome, EPSRC and BBSRC