Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: Synthesis, activity, and modeling

Journal of Medicinal Chemistry

Volumn 41, Issue 5, 1998, Pages 674-681

  Barlocco, Daniela ^a   Cignarella, Giorgio ^a   Tondi, Donatella ^a   Vianello, Paola ^a   Villa, Stefania ^a   Bartolini, Alessandro ^b   Ghelardini, Carla ^b   Galeotti, Nicoletta ^b   Anderson, David J ^c   Kuntzweiler, Theresa A ^c   Colombo, Diego ^d   Toma, Lucio ^e  

^a UNIVERSITY OF MILAN   (Italy)

^b Dipto Farmacol Preclinica e Clin   (Italy)

^c ABBOTT LABORATORIES   (United States)

^d Metallorganica e Analitica   (Italy)

^e Dipartimento di Chimica   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 (6 CHLORO 3 PYRIDAZINYL) 3,8 DIAZABICYCLO[3.2.1]OCTANE; ANALGESIC AGENT; BICYCLO[3.2.1]OCTANE DERIVATIVE; CHOLINERGIC RECEPTOR; CLOMIPRAMINE; DIPHENHYDRAMINE; EPIBATIDINE; MECAMYLAMINE; MORPHINE; NALOXONE; NICOTINE; NICOTINIC RECEPTOR; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HOT PLATE TEST; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ABDOMINAL MUSCLES; ANALGESIA; ANALGESICS, NON-NARCOTIC; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CEREBRAL CORTEX; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MECAMYLAMINE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUSCLE CONTRACTION; NALOXONE; NARCOTIC ANTAGONISTS; PAIN THRESHOLD; PYRIDAZINES; PYRIDINES; RATS; RECEPTORS, CHOLINERGIC;

EID: 15144351544     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970427p     Document Type: Article

References (24)

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