Monoclonal anti-endothelial cell antibodies from a patient with Takayasu arteritis activate endothelial cells from large vessels

Arthritis and Rheumatism

Volumn 42, Issue 7, 1999, Pages 1421-1432

  Blank, Miri ^a   Krause, Ilan ^a   Goldkorn, Tzipora ^f   Praprotnik, Sonja ^a   Livneh, Avi ^a   Langevitz, Pnina ^a   Kaganovsky, Ella ^b   Morgenstern, Sara ^b   Cohen, Shlomo ^a   Barak, Vivian ^c   Eldor, Amiram ^d   Weksler, Babette ^e   Shoenfeld, Yehuda ^a  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^d TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

^f Sheba Medical Center ^*

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MONOCLONAL ANTIBODY; TRANSCRIPTION FACTOR; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AORTA ARCH SYNDROME; ARTICLE; AUTOIMMUNITY; BONE MARROW CELL; CASE REPORT; ELECTROPHORETIC MOBILITY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GREAT BLOOD VESSEL; HUMAN; IMMUNOHISTOCHEMISTRY; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; VIRUS TRANSFORMATION;

ADULT; ANTIBODIES, MONOCLONAL; ANTIBODY FORMATION; CELL ADHESION; CELL ADHESION MOLECULES; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MONOCYTES; NF-KAPPA B; TAKAYASU'S ARTERITIS; U937 CELLS; UMBILICAL VEINS;

EID: 0033508775     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199907)42:7<1421::AID-ANR16>3.0.CO;2-O     Document Type: Article

References (60)

1. Meroni PL, Khamashta MA, Youinou P, Shoenfeld Y. Conference report, mosaic of anti-endothelial antibodies, review of the first international workshop on anti-endothelial antibodies: clinical and pathological significance. Lupus 1995;4:95-9.
2. Adler Y, Salozhin K, Le Tonqueze M, Shoenfeld Y, Youinou P. Anti-endothelial cell antibodies: a need for standardization. Lupus 1994;3:77-84.
3. Youinou P, Meroni PL, Khamashta MA, Shoenfeld Y. A need for standardization of the anti-endothelial-cell antibody test. Immunol Today 1995;16:363-4.
4. Rosenbaum J, Pottinger BE, Woo P, Black CM, Loiza S, Byron MA, et al. Measurement and characterization of circulating anti-endothelial cell IgG in connective tissue diseases. Clin Exp Immunol 1988;72:450-6.
5. Bodolay E, Bojan F, Szegedi G, Stenzky V, Farid NR. Cytotoxic endothelial cell antibodies in mixed connective tissue disease. Immunol Lett 1989;20:163-7.
6. Cines DB, Tomaski A, Tannenbaum S. Immune endothelial cell injury in heparin associated thrombocytopenia. N Engl J Med 1987;316:581-9.
7. Del Papa N, Meroni PL, Barcellini W, Sinicio A, Radice A, Tincani A, et al. Antibodies to endothelial cells in primary vasculitides mediate in vitro endothelial cytotoxicity in the presence of normal peripheral blood mononuclear cells. Clin Immunol Immunopathol 1992;63:267-74.
8. Ferraro G, Meroni PL, Tincani A, Sinicio A, Barcellini W, Radice A, et al. Anti-endothelial cell antibodies in patients with Wegener's granulomatosis and microscopic polyarthritis. Clin Exp Immunol 1990;79:47-53.
9. Navarro M, Cervera R, Font J, Reverter JC, Monteagudo J, Escolar G, et al. Anti-endothelial cell antibodies in systemic autoimmune diseases: prevalence and clinical significance. Lupus 1997;6:521-6.
10. Damianovich M, Gilburd B, George J, Del Papa N, Afek A, Goldberg I, et al. Pathogenic role of antiendothelial cell antibodies (AECA) in vasculitis: an idiotype experimental model. J Immunol 1996;156:4946-51.
11. George J, Blank M, Levy Y, Meroni P, Damianovich M, Tincani A, et al. Differential effects of anti-beta2-glycoprotein I antibodies on endothelial cells and on the manifestations of experimental antiphospholipid syndrome. Circulation 1998;97:900-6.
12. Levy Y, Gilburd B, George J, Del Papa N, Mallone R, Damianovich M, et al. Characterization of murine monoclonal anti-endothelial cell antibodies (AECA) produced by idiotypic manipulation with human AECA. Int Immunol 1998;10:861-8.
13. Carvalho D, Savage COS, Black CM, Pearson J. IgG anti-endothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. J Clin Invest 1996;97:111-9.
14. Simantov R, LaSala JM, Lo SK, Gharavi AE, Sammaritano LR, Salmon JE, et al. Activation of cultured vascular endothelial cells by antiphospholipid antibodies. J Clin Invest 1995;96:2211-9.
15. 2-glycoprotein I and induce endothelial activation. Arthritis Rheum 1997;40:551-61.
16. Del Papa N, Guidali L, Sironi M, Shoenfeld Y, Mantovani A, Tincani A, et al. Anti-endothelial cell IgG antibodies from patients with Wegener's granulomatosis bind to human endothelial cells in vitro and induce adhesion molecule expression and cytokine secretion. Arthritis Rheum 1996;39:758-66.
17. Kerr GS, Hallahan CW, Giordano J, Leavitt RY, Fauci AS, Rottem M, et al. Takayasu's arteritis. Ann Intern Med 1994;120: 919-29.
18. Ishikawa K. Diagnostic approach and proposed criteria for the clinical diagnosis of Takayasu's arteriopathy. J Am Coll Cardiol 1988;12:964-72.
19. Kerr GS. Takayasu's arteritis. Rheum Dis Clin North Am 1995; 21:1041-58.
20. Shelhamer JH, Volkman DJ, Parillo JE, Lawley TJ, Johnston MR, Fauci AS. Takayasu's arteritis and its therapy. Ann Intern Med 1985;103:121-6.
21. Hall S, Barr W, Lie JT, Stanson AW, Kazmier FJ, Hunder GG. Takayasu's arteritis: a study of 32 North American patients. Medicine (Baltimore) 1985;64:89-99.
22. Nakao K, Ikeda K, Kimata M. Takayasu's arteritis: clinical report of 84 cases and immunological studies of 7 cases. Circulation 1967;53:1141-4.
23. Dhingra R, Talwar KK, Chopra P, Kumar R. An enzyme linked immunosorbent assay for detection of anti-aorta antibodies in Takayasu arteritis patients. Int J Cardiol 1993;40:237-42.
24. Sima D, Thiele B, Turowski A, Wilke K, Hiepe F, Volk D, et al. Anti-endothelial antibodies in Takayasu arteritis. Arthritis Rheum 1994;37:441-3.
25. Eichhorn J, Sima D, Thiele B, Lindschau C, Turowski A, Schmidt H, et al. Anti-endothelial cell antibodies in Takayasu's arteritis. Circulation 1996;94:2396-401.
26. Nityanand S, Mishra K, Shrivastava S, Holm G, Lefvert AK. Autoantibodies against cardiolipin and endothelial cells in Takayasu's arteritis: prevalence and isotype distribution. Br J Rheumatol 1997;36:923-4.
27. Manheimer-Lory AJ, Davidson A, Watkins D, Hannigan NR, Diamond BA. Generation and analysis of clonal IgM and IgG-producing B-cell lines expressing an anti-DNA associated idiotype. J Clin Invest 1991;87:1519-25.
28. Parham P. Preparation and purification of active fragments from mouse monoclonal antibodies. In: Herzenberg L, Blackwell C, Herzenberg L, editors. Handbook of experimental immunology. Vol. 2. Cellular immunology. Oxford: Blackwell Scientific; 1989. p. 14.
29. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. J Clin Invest 1973;52:2745-56.
30. Liu ZY, Ganju RK, Wang JF, Schweizer K, Weksler B, Avraham S, et al. Characterization of signal transduction pathways in human bone marrow endothelial cells. Blood 1997;90:2253-9.
31. Hill MB, Phipps JL, Malia G, Greaves M, Hughes P. Characterization and specificity of anti-endothelial cell membrane antibodies and their relationship to thrombosis in primary antiphospholipid syndrome (APS). Clin Exp Immunol 1995;102:368-72.
32. Adamson P, Tighe M, Pearson JD. Protein tyrosine kinase inhibitors act downstream of IL-1 and LPS stimulated MAP-kinase phosphorylation to inhibit expression of E-selectin on human umbilical-vein endothelial cells. Cell Adhes Commun 1996;3:511-25.
33. Wright SD, Detmers PA, Aida Y, Adamowski R, Anderson DC, Chad Z, et al. CD18-deficient cells respond to lipopolysaccharide in-vitro. J Immunol 1990;144:2566-71.
34. Herbert JM, Savi P, Jeske WP, Walenga JM. Effect of SR121566A, a potent GP IIb-IIIa antagonist, on the HIT serum/ heparin-induced platelet mediated activation of human endothelial cells. Thromb Haemost 1998;80:326-31.
35. Van der Zee JM, Heurkens AH, van der Voort EA, Daha MR, Breedveld FC. Characterization of anti-endothelial antibodies in patients with rheumatoid arthritis complicated by vasculitis. Clin Exp Rheumatol 1991;9:589-94.
36. Van der Zee JM, Siegert CE, de Vreede TA, Daha MR, Breedveld FC. Characterization of anti-endothelial cell antibodies in systemic lupus erythematosus (SLE). Clin Exp Immunol 1991;84:238-44.
37. Del Papa N, Conforti G, Gambini D, La Rosa L, Tincani A, D'Cruz D, et al. Characterization of the endothelial surface proteins recognized by anti-endothelial antibodies in primary and secondary autoimmune vasculitis. Clin Immunol Immunopathol 1994;70:211-6.
38. Levy Y, Gilburd B, George J, Del Papa N, Mallone R, Damianovich M, et al. Characterization of murine monoclonal anti-endothelial cell antibodies (AECA) produced by idiotypic manipulation with human AECA. Int Immunol 1998;10:861-8.
39. Lai KN, Leung JC, Lai KB, Wong KC, Lai CKW. Upregulation of adhesion molecule expression on endothelial cells by anti-DNA autoantibodies in systemic lupus erythematosus. Clin Immunol Immunopathol 1996;81:229-38.
40. Pearson JD. Autoantibodies to endothelial cells. In: Catravas J, Callow AR, Ryan US, editors. Vascular endothelium. New York: Plenum Publishing; 1991. p. 117-25.
41. Tannenbaum SH, Finko R, Cines DB. Antibody and immune complexes induce tissue factor production by human endothelial cells. J Immunol 1986;137:1532-7.
42. Hasselaar P, Derksen RHWM, Oosting JD, Blokzijl L, De Groot PG. Synergistic effect of low dosage of tumor necrosis factor and sera from patients with systemic lupus erythematosus on the expression of procoagulant activity by cultured endothelial cells. Thromb Haemost 1989;62:654-60.
43. Tervaert JW, Kallenberg CG. Cell adhesion molecules in vasculitis. Curr Opin Rheumatol 1997;9:16-25.
44. Burrows NP, Molina FA, Terenghi G, Clark PK, Haskard DO, Polak JM, et al. Comparison of cell adhesion molecule expression in cutaneous leucocytoclastic and lymphocytic vasculitis. J Clin Pathol 1994;47:939-44.
45. Leung DYM, Cotran RS, Kurt-Jones E, Burns JC, Newburger JW, Pober JS. Endothelial cell activation and high interleukin-1 secretion in the pathogenesis of acute Kawasaki disease. Lancet 1989; ii:1298-302.
46. Bruyn JA, Dinklo NJCM. Distinct patterns of expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and endothelial-leukocyte adhesion molecule-1 in renal disease. Lab Invest 1993;69:329-35.
47. Rastaldi MP, Ferrario F, Tunesi S, Yang L, D'Amico G. Intraglomerular and interstitial leukocyte infiltration, adhesion molecules, and interleukin-1α expression in 15 cases of antineutrophil cytoplasmic antibody-associated renal vasculitis. Am J Kidney Dis 1996;27:48-57.
48. Coll-Vinent B, Cebrián M, Cid MC, Font C, Esparza J, Juan M, et al. Dynamic pattern of endothelial cell adhesion molecule expression in muscle and perineural vessels from patients with classic polyarteritis nodosa. Arthritis Rheum 1998;41:435-44.
49. Watson C, Whittaker S, Smith N, Vora AJ, Dumonde DC, Brown KA. IL-6 acts on endothelial cells to preferentially increase their adherence for lymphocytes. Clin Exp Immunol 1996;105:112-9.
50. Simmons DL, Needham L. Cloning cell surface molecules using monoclonal antibodies. In: Gordon JL, editor. Vascular endothelium: interactions with circulating cells. Amsterdam: Elsevier Science Publishers; 1991. p. 3-29.
51. Wagner WH, Henderson RM, Hicks HE, Banes AJ, Johnson G Jr. Differences in morphology, growth rate, and protein synthesis between cultured arterial and venous endothelial cells. J Vasc Surg 1988;8:509-19.
52. Shreeniwas R, Ogawa S, Cozzolino F, Torcia G, Braunstein N, Butura C, et al. Macrovascular and microvascular endothelium during long-term hypoxia: alterations in cell growth, monolayer permeability, and cell surface coagulant properties. J Cell Physiol 1991;146:8-17.
53. Doherty DE, Hasslett C, Tonnesen MG, Henson PM. Human monocytic adherence: a primary effect of chemotactic factors on the monocyte to stimulate adherence to human endothelium. J Immunol 1987;138:1762-71.
54. Margolin DA, Madura JA, de la Motte CA, Fox PL, DiCorleto PE, Graham LM. Differential monocytic adherence to specific anatomic regions of the canine aorta. J Vasc Res 1995;32:266-74.
55. Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986;46:705-16.
56. Baldwin AS Jr. The NFκB and NFκB proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-83.
57. Kunsch C, Ruben SM, Rosen CA. Selection of optimal NFκB/Rel DNA-binding motifs: interaction of both subunits of NFκB with DNA is required for transcriptional activation. Mol Cell Biol 1992;12:4412-21.
58. Libermann TA, Baltimore D. Activation of IL-6 gene expression through the NFκB transcription factor. Mol Cell Biol 1990;10: 2327-34.
59. Collart MA, Baeuerle P, Vassalli P. Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four NFκB-like motifs of constitutive and inducible forms of NFκB. Mol Cell Biol 1990;10:1498-506.
60. Wolle J, Ferguson EC, Devall LJ, Boschelli DH, Newton RS, Saxena U. Inhibition of TNF induced human aortic endothelial cell adhesion molecule gene expression by an alkoxybenzo(b)thiophene-2-carboxamide. Biochem Biophys Res Commun 1995;214:6-10.