Protein tyrosine kinase inhibitors act downstream of IL-1α and LPS stimulated MAP-kinase phosphorylation to inhibit expression of E-selectin on human umbilical vein endothelial cells

Cell Adhesion and Communication

Volumn 3, Issue 6, 1996, Pages 511-525

  Adamson, Peter ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cytokines; E selectin; Tyrosine kinase inhibitors

Indexed keywords

CYTOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GENISTEIN; INTERLEUKIN 1ALPHA; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN;

CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; E-SELECTIN; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1; ISOFLAVONES; LIPOPOLYSACCHARIDES; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL VEINS;

EID: 0029900009     PISSN: 10615385     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Adamson, P., Tighe, M., Paterson, H. F., and Pearson, J. D. (1994) Induction of E-selectin by endotoxin is direct and not mediated through intracellular or extracellular release of secondary cytokines. Endothelium (in press).
2. Akiyama, T., Ishida, J., Nakagawa, S., Ogawara, H., Wantanabe, S., Itoh, N., Shibuya, M., and Fukami, Y. (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases J. Biol. Chem. 262, 5592-5595
3. Asahi, M., Yanagi, S., Ohta, A., Inazu, T., Sakai, K., Takeuchi, F., Taniguchi, T, and Yamamura, H. (1992) Thrombin induced human platelet aggregation is inhibited by protein-tyrosine kinase inhibitors, ST638 and genistein FEES Lett. 309, 10-14.
4. Bazil, V., Horejsi, V., Baudys, M., Kristofova, H., Strominger, J., Kostka, W., and Hilgert, I. (1986) Biochemical characterisation of a soluble form of the 53 Kda monocyte surface antigen. Eur. J. Immunol. 16, 1583-1589.
5. Bevilaqua, M. P., Pober, J. S., Mendrick, D. L., Cotran, R. S., and Gimbrone, M.A. Jr (1987) Identification of an inducible endothelial-leukocyte adhesion molecule. Proc. Nail. Acad. Sci. USA 84, 9238-9242.
6. Bevilaqua, M. P. (1993) Endothelial-Leukocyte adhesion molecules. Ann. Rev. Immunol. 11, 767-804.
7. Carlos, T. M., Schwartz, B. R., Kovach, N. L., Yee, E., Rosso, M., Osborn, L., Chi-Rosso, G., Newman, B., Lobb, R., and Harlan, J. (1990) Vascular cell adhesion molecule 1 mediates lymphocyte adherence to cytokine activated cultured human endothelial cells. Blood 76, 965-970.
8. Chomczynski, P. and Sacchi, N. (1987) Single step method of RNA isolation by guanidine thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.