Pathogenic role of anti-endothelial cell antibodies in vasculitis: An idiotypic experimental model

Journal of Immunology

Volumn 156, Issue 12, 1996, Pages 4946-4951

  Damianovich, Maya ^a   Gilburd, Boris ^a   George, Jacob ^a   Del Papa, Nicoletta ^c   Afek, Arnon ^b   Goldberg, Iris ^b   Kopolovic, Yuri ^b   Roth, Daniel ^a   Barkai, Gad ^b   Meroni, Pier Luigi ^c   Shoenfeld, Yehuda ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; FEMALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; VASCULAR ENDOTHELIUM; VASCULITIS; WEGENER GRANULOMATOSIS;

ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; KIDNEY; MICE; MICE, INBRED BALB C; VASCULITIS;

EID: 15844430231     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Meroni, P. L., M. A. Khamashta, P. Youinou, and Y. Shoenfeld. 1995. Mosaic of anti-endothelial antibodies: Review of The First International Workshop on Anti-Endothelial Antibodies: Clinical and Pathological Significance. Lupus 4:95.
2. Youinou, P., P. L. Meroni, A. M. A. Khamashta, and Y. Shoenfeld. 1995. A need for standardization of the anti-endothelial-cell antibody test. Immunol Today 16:363.
3. Brasile, L., J. M. Kremer, J. L. Clarke, and J. Cerilli. 1989. Identification of an autoantibody to vascular endothelial cell-specific antigens in patients with systemic vasculitis. Am. J. Med. 87:74.
4. Savage, C. O. S., B. E. Pottinger, G. Gaskin, C. M. Lockwood, C. D. Pusey, and J. D. Pearson. 1991. Vascular damage in Wegener's granulomatosis and microscopic polyarteritis: presence of anti-endothelial cell antibodies and their relation to antineutrophil cytoplasm antibodies. Clin. Exp. Immunol. 85:14.
5. Rosenbaum, J., B. E. Pottinger, P. Woo, C. M. Black, S. Loizou, M. A. Byron, and J. D. Pearson. 1988. Measurement and characterization of circulating anti-endothelial cells IgG in connective tissue diseases. Clin. Exp. Immunol. 72:450.
6. Ferraro, G., P. L. Meroni, A. Tincani, A. Sinico, W. Barcellini, A. Radice, G. Gregornini, M. Froldi, M. O. Borghi, and G. Balestrieri. 1990. Anti-endothelial cell antibodies in patients with Wegener's granulomatosis and micropolyarteritis. Clin. Exp. Immunol. 79:47.
7. Frampton, G., D. R. Jayne, G. J. Perry, C. M. Lockwood, and J. S. Cameron. 1990. Autoantibodies to endothelial cells and neutrophil cytoplasmic antigens in systemic vasculitis. Clin. Exp. Immunol. 82:227.
8. Chan, T. M., G. Frampton, P. J. Jayne, D. R. W. Perry, C. M. Lockwood, and J. S. Cameron. 1993. Clinical significance of anti-endothelial-cell antibodies in systemic vasculitis: a longitudinal study comparing anti-endothelial-cell antibodies and anti-neutrophil cytoplasm antibodies. Am. J. Kidney Dis. 22:387.
9. Leung, D. Y. M. 1990. New developments in Kawasaki disease. Curr. Opin. Rheumatol. 3:46.
10. van der Zee, J. M., C. E. Siegert, T. A. de Vrede, M. R. Daha, and F. C. Bredveld. 1991. Anti-endothelial cell antibodies in patients with rheumatoid arthritis complicated by vasculitis. Clin. Exp. Rheumatol. 9:589.
11. van der Zee, J. M., C. E. Siegert, T. A. de Vrede, M. R. Daha, and F. C. Bredveld. 1991. Characterization of anti-endothelial cell antibodies in systemic lupus erythematosus (SLE). Clin. Exp. Immunol. 84:218.
12. Del Papa, N., G. Conforti, D. Gambini, L. La Rosa, A. Tincani, D. D'Cruz, M. Khamashta, G. R. V. Hughes, G. Balestrieri, and P. L. Meroni. 1994. Characterization of the endothelial surface proteins recognized by anti-endothelial antibodies in primary and secondary autoimmune vasculitis. Clin. Immunol. Immunopathol. 70:211.
13. Cines, D. B., A. P. Lyss, M. Reeber, M. Bina, and R. J. DeHoratius. 1984. Presence of complement-fixing anti endothelial cell antibodies in systemic lupus erythematosus. J. Clin. Invest. 73:611.
14. Penning, C. A., M. A. French, N. R. Rowell, and P. Hughes. 1985. Antibody dependent cellular cytotoxicity of human vascular endothelium in systemic lupus erythematosus. J. Clin. Lab. Immunol. 17:125.
15. Del Papa, N., P. L. Meroni, W. Barcellini, A. Sinico, A. Radice, A. Tincani, D. D'Cruz, F. Nicoletti, M. O. Borghi, M. Khamashta, G. R. V. Hughes, and G. Balestrieri. 1992. Antibodies to endothelial cells in primary vasculitides mediate in vitro endothelial cytotoxicity in the presence of normal peripheral blood mononuclear cells. Clin. Immunol. Immunopathol. 63:267.
16. Shoenfeld, Y. 1994. Idiotypic induction of autoimmunity: a new aspect of the idiotypic network. FASEB J. 8:1296.
17. Bakimer, R., P. Fishman, M. Blank, B. Sredni, M. Djaldetti, and Y. Shoenfeld. 1992. Induction of primary antiphospholipid syndrome in mice by immunization with human monoclonal anti cardiolipin antibody (H-3). J. Clin. Invest. 89:1558.
18. Shoenfeld, Y. 1992. Induction of experimental primary and secondary anti-phospholipid syndrome in naive mice. Am. J. Reprod. Immunol. 28:219.
19. Blank, M., J. Cohen, V. Toder, and Y. Shoenfeld. 1991. Induction of antiphospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies. Proc. Natl. Acad. Sci. USA 88:3069.
20. Shoenfeld, Y., and E. Mozes. 1990. Pathogenic idiotypes of autoantibodies in autoimmunity: lessions from new experimental model of SLE. FASEB J. 4:2646.
21. Mendlovic, S., S. Brocke, Y. Shoenfeld, M. Ben-Basal, A. Meshorer, R. Bakimer, and E. Mozes. 1988 Induction of an SLE-like disease in mice by a common anti-DNA idiotype. Proc. Natl. Acad. Sci. USA 85:2260.
22. Blank, M., S. Mendlovic, E. Mozes, and Y. Shoenfeld. 1988. Induction of SLE-like disease in naive mice with a monoclonal anti-DNA antibody derived from a patient with polymyositis carrying 16/6 Id. J. Autoimmun. 1:683.
23. Blank, M., Y. Tomer, M. Stein, J. Kopolovic, A. Wiik, P. L. Meroni, G. Conforti, and Y. Shoenfeld. 1995. Immunization with anti-neutrophil cytoplasmic antibody (ANCA) induces the production of mouse ANCA and perivascular lymphocyte infiltration. Clin. Exp. Immunol. 102:120.
24. Tomer, Y., B. Gilburd, M. Blank, O. Lider, R. Hershkovic, P. Fishman, R. Zigelman, P. L. Meroni, A. Wiik, and Y. Shoenfeld. 1995. Characterization of biologically active ANCA induced in mice; pathogenic role in experimental vasculitis. Arthritis. Rheum. 38:1375.
25. Shoenfeld, Y., Y. Tomer, and M. Blank. 1995. A new experimental model for Wegener's granulomatosis. Isr. J. Med. Sci. 31:13.
26. Bygren, P., N. Rasmussen, B. Isaksson, and J. Wieslander. 1992. Anti-neutrophil cytoplasm antibodies, anti-GBM antibodies and anti-dsDNA antibodies in glomerulonephritis. Eur. J. Clin. Invest. 22:783.
27. Del Papa, N., L. Guidali, L. Spatola, P. Bonara, M. O. Borghi, A. Tincani, G. Balestrieri, and P. L. Meroni. 1995. Relationship between anti-phospholipid and anti-endothelial cell antibodies. III: β-2 Glycoprotein I mediates the antibody binding to endothelial membranes and induces the expression of adhesion molecules. Clin. Exp. Rheumatol. 13:179.
28. Shoenfeld, Y., J. Rauch, H. Massicotte, S. K. Datta, A. J. Schwartz, B. D. Stollar, and R. S. Schwartz. 1983. Polyspecificity of monoclonal lupus autoantibodies produced by human-human hybridomas. N. Engl. J. Med. 308:414.
29. Tincani, A., G. Balestrieri, F. Allegri, R. Cattaneo, A. Fornasieri, M. Li, A. Sinico, and G D'Amico. 1993. Induction of experimental SLE in naive mice by immunization with human polyclonal anti-DNA antibody carrying the 16/6 idiotype. Clin. Exp. Rheum. 11:129.
30. Leung, D. Y. M., T. Collins, L. A. Lapierre, R. S. Geha, and J. S. Pober. 1986. Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon. J. Clin. Invest. 77:1428.
31. Lindquist, K. J., and C. K. Osterland. 1971. Human antibodies to vascular endothelium. Clin. Exp. Immunol. 9:753.
32. Mayet, W. J., A. Schwarting, and K. H. Meyer Zum Buschenfelde. 1994. Cytotoxic effect of antibodies to proteinase 3 (cANCA) on human endothelial cells. Clin. Exp. Immunol. 97:458.
33. Gross, V. L., W. H. Schmitt, and E. Csernok. 1993. ANCA and associated diseases: immunodiagnostic and pathogenetic aspects. Clin. Exp. Immunol. 91:1.
34. Del Papa, N., L. Guidali, M. Sironi, Y. Shoenfeld, A. Tincani, G. Balestrieri, A. Radice, R. A. Sinico, A. Mantovani, and P. L. Meroni. 1995. Anti-endothelial IgG antibodies from Wegener's granulomatosis bind to human endothelial cells and induce adhesion molecules expression and cytokine secretion. Arthritis Rheum. In press.
35. Dang, H., N. Ogawa, M. Takei, K. Lazaridis, and N. Talal. 1993. Induction of lupus-associated autoantibodies by immunization with native and recombinant Ig polypeptides expressing a cross-reactive idiotype 4B4. J. Immunol. 151:7260.
36. Pierangeli, S. S., and E. N. Harris. 1993. Induction of phospholipid antibodies in mice and rabbits by immunization with human beta 2 glycoprotein 1 or anticardiolipin antibodies alone. Clin. Exp. Immunol. 93:269.
37. D'Cruz, D. P., F. A. Houssian, G. Ramirez, E. Baguley, J. McCutcheon, J. Vianna, H. J. Haga, G. T. Swana, M. A. Khamashta, J. C. Taylor, D. R. Davis, and G. R. V. Hughes. 1991. Antibodies to endothelial cells in systemic lupus erythematosus: a potential marker for nephritis and vasculitis. Clin. Exp. Immunol. 85:254.
38. Del Papa, N., P. L. Meroni, A. Tincani, E. N. Harris, S. S. Pierangeli, W. Barcellini, M. O. Borghi, G. Balestrieri, and C. Zanussi. 1992. Relationship between anti-phospholipid and anti-endothelial cell antibodies: further characterization of the reactivity on resting and cytokine-activated endothelial cells. Clin. Exp. Rheumatol. 10:37.
39. Cervera, R., M. A. Khamashta, and G. R. V. Hughes. 1993. Antibodies to Endothelial Cells and Vascular Damage. Vol. 83. CRC Press, Boca Raton, FL, p. 184.
40. Haynes, B. F. 1992. Pathogenetic mechanisms of vessel damage. In: Inflamation: Basic Principles and Clinical Correlates, 2nd Ed., Vol. 921. J. I. Gallin, I. M. Goldstein, and R. Snyderman, eds. Ravena Press, New York, p. 941.