PU.1, a shared transcriptional regulator of lymphoid and myeloid cell fates

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 64, Issue , 1999, Pages 13-20

  Singh, H ^a   DeKoter, R P ^a   Walsh, J C ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; INTERLEUKIN 7; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR SP1; ACTIVIN A; COMPLEMENTARY DNA; IMMUNOGLOBULIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PU 1;

BONE MARROW CELL; CELL DIFFERENTIATION; CELL LINEAGE; CONFERENCE PAPER; CONSENSUS SEQUENCE; DNA BINDING; GENE EXPRESSION REGULATION; HEMATOPOIETIC SYSTEM; IMMUNE SYSTEM; LYMPHOID CELL; LYMPHOPOIESIS; MYELOPOIESIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTO ONCOGENE; STEM CELL; TRANSCRIPTION REGULATION; ARTICLE; CELL FATE; DNA TRANSCRIPTION; ERYTHROBLAST; FETUS LIVER; GENE MUTATION; HEMATOPOIETIC CELL; HUMAN; MYELOID PROGENITOR CELL; NEUTROPHIL; T LYMPHOCYTE; UPREGULATION;

EID: 0033504730     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1999.64.13     Document Type: Conference Paper

References (24)

1. Brass A.L., Kehrli E., Eisenbeis C.F, Storb U., and Singh H. 1996. Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1. Genes Dev. 10: 2335.
2. Brown G., Bunce C.M., Howie A.J., and Lord J.M. 1987. Stochastic or ordered lineage commitment during hemopoiesis? Leukemia 1: 150.
3. Cumano A., Paige C.J., Iscove N.N, and Brady.G. 1992. Bipotential precursors of B cells and macrophages in murine fetal liver. Nature 356: 612.
4. DeKoter R.P., Walsh J.C., and Singh H. 1998. PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.EMBO J. 17: 4456.
5. Eisenbeis C.F., Singh H, and Storb U. 1995. Pip, a novel IRF family member, is a lymphoid-speciftc, PU.1-dependent transcriptional activator. Genes Dev. 9: 1377.
6. Fisher R.C. and Scott E.W. 1998. Role of PU.1 in hematopoiesis. Stem Cells 16: 25.
7. Georgopoulos K. 1997. Transcription factors required for lymphoid lineage commitment. Curr. Opin. Immunol. 9: 222.
8. Glimcher L.H. and Singh H. 1999. Transcription factors in lymphocyte development - T and B cells get together. Cell 96:13.
9. Hromas R., Orazi A., Neiman R.S., Maki R., Van Beveren C., Moore J., and Klemsz M. 1993. Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1. Blood 82: 2998.
10. Klemsz M.J. and Maki R.A. 1996. Activation of transcription by PU.1 requires both acidic and glutamine domains. Mol. Cell. Biol. 16: 390.
11. Kodandapani R., Pio F., Ni C., Piccialli G., Klemsz M., McKercher S., Maki R.A., and Ely K.R. 1996. A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex. Nature 380: 456.
12. Kondo M., Weissman I.L., and Akashi K. 1997. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91: 661.
13. Lacaud G., Carlsson L., and Keller G. 1998. Identification of a fetal hematopoietic precursor with B cell, T cell and macrophage potential. Immunity 9: 827.
14. McKercher S.R., Torbett B.E., Anderson K.L., Henkel G.W., Vestal D.G., Baribault H., Klemsz M., Feeney A.J., Wu G.E., Paige C.J., and Maki R.A. 1996. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 15:5647.
15. Moreau-Gachelin F. 1994. Spi/PU.1: An oncogene of the Ets family. Biochim. Biophys. Acta 1198: 149.
16. Moreau-Gachelin F., Tavitian A, and Tambourin P. 1988. Spi-1 is a putative oncogene in virally induced murine erythroleukemias. Nature 331: 277.
17. Moreau-Gachelin F., Wendling F., Molina T., Denis N., Titeux M., Grimber G., Briand P., Vainchenker W., and Tavitian A. 1996. Spi-1/PU.1 transgenic mice develop multistep erythroleukemias. Mol. Cell. Biol. 16: 2453.
18. Pongubala J.M., Van Beveren C., Nagulapalli S., Klemsz M.J., McKercher S.R., Maki R.A., and Atchison M.L. 1993. Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation. Science 259: 1622.
19. Ray-Gallet D., Mao C., Tavitian A., and Moreau-Gachelin F. 1995. DNA-binding specificities of Spi-1/PU.1 and Spi-B transcription factors and identification of a Spi-1/Spi-B binding site in the c-fes/c-fps promoter. Oncogene, 11: 303.
20. Scott E.W., Simon M.C., Anastasi J., and Singh H. 1994. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265: 1573.
21. Scott E.W., Fisher R.C., Olson M.C., Kehrli B.W., Simon M.C., and Singh H. 1997. PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity 6: 437.
22. Shivdasani R.A. and Orkin S.H. 1996. The transcriptional control of hematopoiesis. Blood 87: 4025.
23. Singh H. 1996. Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates. Curr. Opin. Immunol. 8: 160.
24. Tenen D.G., Hromas R., Licht J.D., and Zhang D.E. 1997. Transcription factors, normal myeloid development, and leukemia. Blood 90: 489.