메뉴 건너뛰기




Volumn 280, Issue 5371, 1998, Pages 1871-1873

HIV treatment failure: Testing for HIV resistance in clinical practice

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; GAG PROTEIN; LAMIVUDINE; NEVIRAPINE; PROTEINASE INHIBITOR;

EID: 0032547101     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5371.1871     Document Type: Short Survey
Times cited : (196)

References (40)
  • 1
    • 0032548547 scopus 로고    scopus 로고
    • J. Cohen, Science 279, 1133 (1998).
    • (1998) Science , vol.279 , pp. 1133
    • Cohen, J.1
  • 2
    • 9844238154 scopus 로고    scopus 로고
    • M. Egger et al., Br. Med. J. 315, 1194 (1997); Y. Mouton et al., AIDS 11, F101; F. Palella, N. Engl. J. Med. 338, 853 (1998); B. Hirschel and P. Francioli, ibid., p. 906.
    • (1997) Br. Med. J. , vol.315 , pp. 1194
    • Egger, M.1
  • 3
    • 9844261693 scopus 로고    scopus 로고
    • M. Egger et al., Br. Med. J. 315, 1194 (1997); Y. Mouton et al., AIDS 11, F101; F. Palella, N. Engl. J. Med. 338, 853 (1998); B. Hirschel and P. Francioli, ibid., p. 906.
    • AIDS , vol.11
    • Mouton, Y.1
  • 4
    • 2642709177 scopus 로고    scopus 로고
    • M. Egger et al., Br. Med. J. 315, 1194 (1997); Y. Mouton et al., AIDS 11, F101; F. Palella, N. Engl. J. Med. 338, 853 (1998); B. Hirschel and P. Francioli, ibid., p. 906.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 853
    • Palella, F.1
  • 5
    • 9844238154 scopus 로고    scopus 로고
    • M. Egger et al., Br. Med. J. 315, 1194 (1997); Y. Mouton et al., AIDS 11, F101; F. Palella, N. Engl. J. Med. 338, 853 (1998); B. Hirschel and P. Francioli, ibid., p. 906.
    • N. Engl. J. Med. , pp. 906
    • Hirschel, B.1    Francioli, P.2
  • 6
    • 0030712305 scopus 로고    scopus 로고
    • J. K. Wong et al., Science 278, 1291 (1997); D. Finzi et al., ibid, p. 1295; T. W. Chun et al., Proc. Natl. Acad. Sci. U.S.A. 24, 13193 (1997).
    • (1997) Science , vol.278 , pp. 1291
    • Wong, J.K.1
  • 7
    • 0030712305 scopus 로고    scopus 로고
    • J. K. Wong et al., Science 278, 1291 (1997); D. Finzi et al., ibid, p. 1295; T. W. Chun et al., Proc. Natl. Acad. Sci. U.S.A. 24, 13193 (1997).
    • Science , pp. 1295
    • Finzi, D.1
  • 8
    • 0030659177 scopus 로고    scopus 로고
    • J. K. Wong et al., Science 278, 1291 (1997); D. Finzi et al., ibid, p. 1295; T. W. Chun et al., Proc. Natl. Acad. Sci. U.S.A. 24, 13193 (1997).
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.24 , pp. 13193
    • Chun, T.W.1
  • 10
    • 0030792728 scopus 로고    scopus 로고
    • Lorenzi et al., AIDS 11, F 95 (1997).
    • (1997) AIDS , vol.11
    • Lorenzi1
  • 11
    • 0030868897 scopus 로고    scopus 로고
    • B. Autran et al., Science 277, 112 (1997).
    • (1997) Science , vol.277 , pp. 112
    • Autran, B.1
  • 12
    • 0032492398 scopus 로고    scopus 로고
    • D. Kaufmann, G. Pantaleo, P. Sudre, A. Telenti, Lancet 351, 723 (1998); S. Deeks, abstract 419 presented at the Fifth Conference on Retrovirus and Opportunistic Infections, Chicago, 1998 (Foundation for Retrovirology and Human Health, Alexandria, VA).
    • (1998) Lancet , vol.351 , pp. 723
    • Kaufmann, D.1    Pantaleo, G.2    Sudre, P.3    Telenti, A.4
  • 13
    • 0032492398 scopus 로고    scopus 로고
    • abstract 419 Chicago, Foundation for Retrovirology and Human Health, Alexandria, VA
    • D. Kaufmann, G. Pantaleo, P. Sudre, A. Telenti, Lancet 351, 723 (1998); S. Deeks, abstract 419 presented at the Fifth Conference on Retrovirus and Opportunistic Infections, Chicago, 1998 (Foundation for Retrovirology and Human Health, Alexandria, VA).
    • (1998) Fifth Conference on Retrovirus and Opportunistic Infections
    • Deeks, S.1
  • 14
    • 0028874048 scopus 로고
    • D. D. Ho et al., Nature 373, 123 (1995); N. Sachsenberg et al., J. Exp. Med. 187, 1295 (1998), M. Roederer, Nature Med. 4, 145 (1998).
    • (1995) Nature , vol.373 , pp. 123
    • Ho, D.D.1
  • 15
    • 0032550369 scopus 로고    scopus 로고
    • D. D. Ho et al., Nature 373, 123 (1995); N. Sachsenberg et al., J. Exp. Med. 187, 1295 (1998), M. Roederer, Nature Med. 4, 145 (1998).
    • (1998) J. Exp. Med. , vol.187 , pp. 1295
    • Sachsenberg, N.1
  • 16
    • 0031883405 scopus 로고    scopus 로고
    • D. D. Ho et al., Nature 373, 123 (1995); N. Sachsenberg et al., J. Exp. Med. 187, 1295 (1998), M. Roederer, Nature Med. 4, 145 (1998).
    • (1998) Nature Med. , vol.4 , pp. 145
    • Roederer, M.1
  • 18
    • 0030953711 scopus 로고    scopus 로고
    • Transmission of isolates carrying azidothymidine resistance mutations occurs in 5 to 10% of episodes of primary infection and of perinatal contamination. Transmission of nevirapine-resistant clones has also been reported. [Imrie et al., J. Infect. Dis. 175, 1502 (1997); Qiugg et al., AIDS 11, 835 (1997); S. Yerly et al., Schweiz. Med. Wochensch. 126, 1845 (1996)]. Transmission of multidrug-resistant HIV carrying mutations to protease inhibitors has recently been observed by S. Yerly et al. (personal communication).
    • (1997) J. Infect. Dis. , vol.175 , pp. 1502
    • Imrie1
  • 19
    • 0030953711 scopus 로고    scopus 로고
    • Transmission of isolates carrying azidothymidine resistance mutations occurs in 5 to 10% of episodes of primary infection and of perinatal contamination. Transmission of nevirapine-resistant clones has also been reported. [Imrie et al., J. Infect. Dis. 175, 1502 (1997); Qiugg et al., AIDS 11, 835 (1997); S. Yerly et al., Schweiz. Med. Wochensch. 126, 1845 (1996)]. Transmission of multidrug-resistant HIV carrying mutations to protease inhibitors has recently been observed by S. Yerly et al. (personal communication).
    • (1997) AIDS , vol.11 , pp. 835
    • Qiugg1
  • 20
    • 0030603259 scopus 로고    scopus 로고
    • Transmission of isolates carrying azidothymidine resistance mutations occurs in 5 to 10% of episodes of primary infection and of perinatal contamination. Transmission of nevirapine-resistant clones has also been reported. [Imrie et al., J. Infect. Dis. 175, 1502 (1997); Qiugg et al., AIDS 11, 835 (1997); S. Yerly et al., Schweiz. Med. Wochensch. 126, 1845 (1996)]. Transmission of multidrug-resistant HIV carrying mutations to protease inhibitors has recently been observed by S. Yerly et al. (personal communication).
    • (1996) Schweiz. Med. Wochensch. , vol.126 , pp. 1845
    • Yerly, S.1
  • 21
    • 0030953711 scopus 로고    scopus 로고
    • personal communication
    • Transmission of isolates carrying azidothymidine resistance mutations occurs in 5 to 10% of episodes of primary infection and of perinatal contamination. Transmission of nevirapine-resistant clones has also been reported. [Imrie et al., J. Infect. Dis. 175, 1502 (1997); Qiugg et al., AIDS 11, 835 (1997); S. Yerly et al., Schweiz. Med. Wochensch. 126, 1845 (1996)]. Transmission of multidrug-resistant HIV carrying mutations to protease inhibitors has recently been observed by S. Yerly et al. (personal communication).
    • Yerly, S.1
  • 22
  • 23
    • 0029798237 scopus 로고    scopus 로고
    • N. A. Roberts, J. C. Craig, J. Sheldon, AIDS 12, 453 (1998); D. V. Havlir, D. D. Richmann, J. Virol. 70, 7894 (1996).
    • (1996) J. Virol. , vol.70 , pp. 7894
    • Havlir, D.V.1    Richmann, D.D.2
  • 24
    • 0030769354 scopus 로고    scopus 로고
    • Y.-M. Zhang et al., J. Virol. 71, 6662 (1997); L. Stuyver et al., Antimicrob. Agents Chemother. 41, 284 (1997); M. J. Kozal et al., Nature Med. 2, 753 (1996).
    • (1997) J. Virol. , vol.71 , pp. 6662
    • Zhang, Y.-M.1
  • 25
    • 0031046755 scopus 로고    scopus 로고
    • Y.-M. Zhang et al., J. Virol. 71, 6662 (1997); L. Stuyver et al., Antimicrob. Agents Chemother. 41, 284 (1997); M. J. Kozal et al., Nature Med. 2, 753 (1996).
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 284
    • Stuyver, L.1
  • 26
    • 15844378825 scopus 로고    scopus 로고
    • Y.-M. Zhang et al., J. Virol. 71, 6662 (1997); L. Stuyver et al., Antimicrob. Agents Chemother. 41, 284 (1997); M. J. Kozal et al., Nature Med. 2, 753 (1996).
    • (1996) Nature Med. , vol.2 , pp. 753
    • Kozal, M.J.1
  • 28
    • 0028273314 scopus 로고
    • R. W. Shafer et al., J. Infect. Dis. 169, 722 (1994); M. Nijhuis et al., ibid. 176, 398 (1997); M. A. Winters et al., Antimicrob. Agents Chemother. 41, 757 (1997).
    • (1994) J. Infect. Dis. , vol.169 , pp. 722
    • Shafer, R.W.1
  • 29
    • 0030818643 scopus 로고    scopus 로고
    • R. W. Shafer et al., J. Infect. Dis. 169, 722 (1994); M. Nijhuis et al., ibid. 176, 398 (1997); M. A. Winters et al., Antimicrob. Agents Chemother. 41, 757 (1997).
    • (1997) J. Infect. Dis. , vol.176 , pp. 398
    • Nijhuis, M.1
  • 30
    • 0030892246 scopus 로고    scopus 로고
    • R. W. Shafer et al., J. Infect. Dis. 169, 722 (1994); M. Nijhuis et al., ibid. 176, 398 (1997); M. A. Winters et al., Antimicrob. Agents Chemother. 41, 757 (1997).
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 757
    • Winters, M.A.1
  • 32
    • 0344474694 scopus 로고    scopus 로고
    • R. Jellinger, R. Shafer, T. Merigan, J. Infect. Dis. 175, 561 (1996); K. Hertogs et al., Antimicrob. Agents Chemother. 42, 269 (1998).
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 269
    • Hertogs, K.1
  • 34
    • 0030935663 scopus 로고    scopus 로고
    • personal communication
    • A. Gervaix et al., Proc. Natl. Acad. Sci. U.S.A. 94, 4653 (1997); A. Gervaix, personal communication.
    • Gervaix, A.1
  • 35
    • 0030712305 scopus 로고    scopus 로고
    • Although resistance mutations to one of the nucleoside analogs in HAART may not preclude long-term viral suppression, it does predict early rebound if treatment is simplified [J. K. Wong et al., Science 278, 1291 (1997); R. Raffi et al., abstract LB15 presented at the Fifth Conference on Retrovirus and Opportunistic Infections, Chicago, 1998 (Foundation for Retrovirology and Human Health, Alexandria, VA); D. V. Havlir et al., ibid, abstract LB16].
    • (1997) Science , vol.278 , pp. 1291
    • Wong, J.K.1
  • 36
    • 0030712305 scopus 로고    scopus 로고
    • abstract LB15 Chicago, Foundation for Retrovirology and Human Health, Alexandria, VA
    • Although resistance mutations to one of the nucleoside analogs in HAART may not preclude long-term viral suppression, it does predict early rebound if treatment is simplified [J. K. Wong et al., Science 278, 1291 (1997); R. Raffi et al., abstract LB15 presented at the Fifth Conference on Retrovirus and Opportunistic Infections, Chicago, 1998 (Foundation for Retrovirology and Human Health, Alexandria, VA); D. V. Havlir et al., ibid, abstract LB16].
    • (1998) Fifth Conference on Retrovirus and Opportunistic Infections
    • Raffi, R.1
  • 37
    • 0030712305 scopus 로고    scopus 로고
    • Chicago, abstract LB16
    • Although resistance mutations to one of the nucleoside analogs in HAART may not preclude long-term viral suppression, it does predict early rebound if treatment is simplified [J. K. Wong et al., Science 278, 1291 (1997); R. Raffi et al., abstract LB15 presented at the Fifth Conference on Retrovirus and Opportunistic Infections, Chicago, 1998 (Foundation for Retrovirology and Human Health, Alexandria, VA); D. V. Havlir et al., ibid, abstract LB16].
    • Fifth Conference on Retrovirus and Opportunistic Infections
    • Havlir, D.V.1
  • 38
    • 2642704778 scopus 로고    scopus 로고
    • abstract St. Petersburg, FL
    • Once virological failure takes place, resistance testing confirms the presence of mutant viruses. Rarely, if no mutation is identified, it may suggest the possibility of retaining one of the drugs of the combination or the existence of problems in adherence to the treatment [D. Mayers et al., abstract presented at the International Workshop on HIV Drug Resistance, Treatment Strategies, and Eradication, St. Petersburg, FL, 1997].
    • (1997) International Workshop on HIV Drug Resistance, Treatment Strategies, and Eradication
    • Mayers, D.1
  • 40
    • 2642607590 scopus 로고    scopus 로고
    • note
    • We thank D. Kaufmann and S. Yerly for invaluable help. Supported by the Swiss National Science Foundation and the Swiss Federal Office for Public Health.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.