Lack of T-cell proliferative response to HIV-1 antigens after 1 year of highly active antiretroviral treatment in early HIV-1 disease

Lancet

Volumn 352, Issue 9135, 1998, Pages 1194-1195

  Plana, Montserrat ^b   Garcia, Felipe ^b   Gallart, Teresa ^b   Miró, José M ^b   Gatell, José M ^a  

^a HOSPITAL CLÍNIC   (Spain)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; DIDANOSINE; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; LAMIVUDINE; POKEWEED MITOGEN; RITONAVIR; STAVUDINE; ZALCITABINE; ZIDOVUDINE;

ARTICLE; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS LOAD; VIRUS REPLICATION;

EID: 0032505665     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)60532-6     Document Type: Article

References (5)

1. 1 Rosenberg ES, Billingsley JM, Caliendo AM, et al. Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science 1997; 278: 1447-50.
2. 2 Carlesimo M, Pontessilli O, Varani AR, et al. CD28 stimulation and T lymphocyte proliferative responses in HIV-1 infection. Clin Exp Immunol 1998; 109: 406-11.
3. 3 Autran B, Carcelain T, Li TS, et al. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostatis and function in advanced HIV disease. Science 1997; 277: 112-16.
4. 4 Davignon JL, Clement D, Alriquet J, Michelson S, Davrinche C. Analysis of the proliferative T cell response to human cytomegalovirus major immediate-early protein (E1): phenotype, frequency and variability. Scand J immunol 1995; 41: 247-55.
5. 5 Waldrop SL, Pitcher CJ, Peterson DM, Maino VC, Picker LJ. Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry. Evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency. J Clin Invest 1997; 7: 1739-50.