Immunoregulation of encephalitogenic MBP-NAc1-11-reactive T cells by CD4+ TCR-specific T cells involves IL-4, IL-10 and IFN-γ

Autoimmunity

Volumn 31, Issue 4, 1999, Pages 237-248

  Adlard, Kirsten ^a   Tsaknaridis, Laura ^a   Beam, Aaron ^a   Bebo Jr , Bruce F ^a,b   Vandenbark, Arthur A ^a,b   Offner, Halina ^a,b  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Experimental autoimmune encephalomyelitis; Regulatory cytokines; TCR regulation; Transgenic mice

Indexed keywords

GAMMA INTERFERON ANTIBODY; INTERLEUKIN 10 ANTIBODY; INTERLEUKIN 4 ANTIBODY; MYELIN BASIC PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL SPECIFICITY; CYTOKINE PRODUCTION; FEMALE; IMMUNOREGULATION; INHIBITION KINETICS; MALE; MOUSE; NONHUMAN; REGULATORY MECHANISM; REVERSAL REACTION; T LYMPHOCYTE; TH1 CELL;

EID: 0033491623     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939908994069     Document Type: Article

References (34)

1. Paterson, P.Y. Fxperimental allergic encephalomyclitis and autoimmune disease. Adv. Immunol. 1986; 5: 131.
2. Pettinelli, C. B. and McFarlin, D.E. Adoptive transfer of experimental allergic encephalomyclitis in SJL J mice after in vitro activation of lymph node cells by myclin basic protein: requirement for Lyt-1.2- T lymphocytes. J. Immunol. 1981; 127: 1420.
3. Miller, S.D. and Karpus, W.J. The immunopathogenesis and regulation of T-cell-mediated demyclinating diseases. Immunol. Today 1994; 15; 356-361.
4. Selmaj, K.W. and Raine, C.S. Tumor necrosis factor mediates myclin and oligodendrocyte damage in vitro. Ann. Neurol. 1988; 23: 339-346.
5. Karpus, W.J. and Swanborg, R.H. CD4+ suppressor cells inhibit the function of effector cells of EAE through a mechanism involving transforming growth factor-beta. J. Immunol. 1991; 146: 1163-1168.
6. Cua, D.J., Hinton, D.R. and Stohlman, S.A. Self-antigen-induced Th2 responses in experimental allergic encephalomyclitis (EAE)-resistant mice. Th2-mediated suppression of autoimmune disease. J. Immunol. 1995; 155: 4052.
7. Kuchroo, V.K., Das, M.P., Brown, J.A., Ranger, A.M., Zamvil, S.S., Sobel, R.A. et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1 Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995; 80: 707.
8. Shaw, M.K., Lorens, J.B., Dhawan, A., DalCanto, R., Tse, H.Y., Tran. A.B. et al. Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyclitis. J. Exp. Med. 1997; 185: 1711.
9. Burns, F.R., Li, X., Shen, N., Offner, H., Chou, Y., Vandenbark, A.A. et al. Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myclin basic protein use similar V and V.β chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J. Exp. Med. 1989; 169: 27-39.
10. Vandenbark, A.A., Hashim, G. and Offner, H. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyclitis. Nature 1989; 341: 541-544.
11. Offner, H., Hashim, G.A. and Vandenbark, A.A. T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science 1991; 251: 430-432.
12. Howell, M.D., Winters, ST., Olee, T., Powell, H.C., Carlo, D.J. and Brostoff, S.W. Vaccination against experimental allergic encephalomyclitis with T cell receptor peptides, Science (Wash. DC) 1989; 246: 668-670.
13. Offner, H., Adlard, K., Bebo Jr., B.F., Schuster, J., Burrows, G.G., Buenafe, A.C. et al. Vaccination with BV8S2 protein amplifies TCR specific regulation and protection against experimental autoimmune encephalomyclitis in TCR BV8S2 transgenic mice. J. Immunol. 1998; 161: 2178-2186.
14. Vandenbark, A.A., Hashim, G.A. and Offner, H. T cell receptor peptides in treatment of autoimmune disease: rationale and potential. J. Neurosci. Res. 1996; 43: 391-402.
15. Weinberg, A.D., Celnik, B., Vainiene, M., Buenafe, A.C., Vandenbark, A.A. and Offner, H. The effect of TCR Vβ8 peptide therapy on T cell populations isolated from the spinal cords of Lewis rats with experimental autoimmune encephalomyclitis. J. Neuroimmunol. 1994; 49: 161.
16. Kumar, V. and Sercarz, E.E. The involvement of T cell receptor peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease. J. Exp. Med. 1993; 178: 909-916.
17. Kumar, V., Tabibiazar, R., Geysen, H.M. and Sercarz, E. Immunodominant framework region 3 peptide from TCR Vβ8.2 chain controls murine experimental autoimmune encephalomyclitis. J. Immunol. 1995; 154: 1941-1950.
18. Kumar, V. and Sercarz., E. Induction or protection from experimental autoimmune encephalomyclitis depends on the cytokine secretion profile of TCR peptide specific regulatory CD4 T cells. J. Immunol. 1998; 161: 6585-6591.
19. Kennedy, M.K., Torrance, D.S., Picha, K.S. and Mohler, K.M. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyclitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 1992; 149: 2496-2505.
20. Kumar, V., Stellrecht, K. and Sercarz, E. Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyclitis (EAE). J. Exp. Med. 1996; 184: 1609-1617.
21. Siklodi, B., Jacobs, R., Burrows, G.G., Vandenbark, A.A. and Offner, H. Neonatal exposure of TCR BV8S2 transgenic mice to recombinant TCR BV8S2 results in reduced T cell proliferation and elevated antibody response to BV8S2 and increased severity of EAE. J. Neurosci. Res. 1998; 52: 750.
22. Goverman, J., Woods, A., Larson, L., Weiner, L.P. and Zaller, D.M. Transgenic mice that express a myclin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 1993; 72: 551-560.
23. Vainiene, M., Burrows, G.G., Ariail, K., Robey, I., Vandenbark, A.A. and Offner, H. Neonatal injection of Lewis rats with recombinant Vβ3.2 induces T cell but not B cell tolerance and increased severity of experimental autoimmune encephalomyclitis. J. Neurosci. Res. 1996; 45: 475-486.
24. Hashim, G.A., Day, E.D., Fredane, L., Intintola, P. and Canalho, E. Biological activity of region 65 to 102 of the myclin basic protein. J. Neurosci. Res. 1986; 16: 467.
25. Voorthuis, J.A.C., Uitdehaag, B.M.J., DeGroot, C.J.A., Goede., P.H., VanDerMeide, P.H. and Dijkstra, C.D. Suppression of experimental allergic encephalomyclitis by intraventricular administration of interferon-gamma in Lewis rats. Clin. Exp. Immunol. 1990; 81: 183.
26. Billiau, A., Heremans, H., Vandekerckhove, F., Dijkmans, R., Sobis, H., Meulepas, E. et al. Enhancement of experimental allergic encephalomyclitis in mice by antibodies against IFN-gamma. J. Immunol. 1988; 140: 1506.
27. Duong, T.T., Finkelman, F.D., Singh, G. and Strejan, G.H. Effect of anti-interferon-gamma monoclonal antibody treatment on the development of experimental allergic encephalomyclitis in resistant mouse strains. J. Neuroimmunol. 1994; 53: 101.
28. O'Garra, A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 1998; 8: 275.
29. Chou, Y.K., Weinberg, A.D., Buenafe, A., Bourdette, D.N., Whitham, R., Kaleeba, J.A.R et al. MHC-restriction, cytokine profile, and immunoregulatory effects of human T cells specific for TCR VB CDR2 peptides; comparison with myclin basic protein-specific T cells. J. Neurosci. Res. 1996; 45: 838-851.
30. Vandenbark, A.A., Chou, Y.K., Whitham, R., Mass, M., Buenafe, A., Liefeld, D. et al. Treatment of multiple sclerosis with T cell receptor peptides: results of a double-blind pilot trial. Nature Med. 1996; 2: 1109-1115.
31. Vandenbark, A.A., Chou, Y.K., Bourdette, D.N., Whitham, R. and Offner, H. Therapeutic application of T cell receptor peptides. Drug News Persp. 1997; 10: 341-346.
32. Kumar, V., Serearz, E. and Adorini, L. Regulatory mechanisms in organ-specific autoimmunity. The Immunologist 1998; 6: 161-166.
33. Zhang, J., Medaer, R., Stinissen, P., Hafler, D.A. and Raus, J.C.M. MHC-restricted depletion of human myclin basic protein-reactive T cells by T cell vaccination. Science 1993; 261: 1451-1454.
34. Lehmann, P.V., Forsthuber, T. and Sercarz, E.E. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 1992; 358: 155-157.