Steroids inhibit uptake and/or processing but not presentation of antigen by airway dendritic cells

Immunology

Volumn 91, Issue 1, 1997, Pages 145-150

  Holt, P G ^a   Thomas, J A ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; STEROID; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; DENDRITIC CELL; LYMPHOCYTE ACTIVATION; MIXED LYMPHOCYTE REACTION; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT INFLAMMATION; T LYMPHOCYTE;

EID: 0030973819     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1997.00321.x     Document Type: Article

References (26)

1. HOLT P.G., SCHON-HEGRAD M.A., PHILLIPS M.J. & MCMENAMIN P.G. (1989) Ia-positive dendritic cells form a tightly meshed network within the human airway epithelium. Clin Exp Allergy 19, 597.
2. HOLT P.G., SCHON-HEGRAD M.A., OLIVER J., HOLT B.J. & MCMENAMIN P.G. (1990) A contiguous network of dendritic antigen-presenting cells within the respiratory epithelium. Int Arch Allergy Appl Immunol 91, 155.
3. SERTL K., TAKEMURA T., TSCHACHLER E., FERRANS V.J., KALINER M.A. & SHEVACH E.M. (1986) Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura. J Exp Med 163, 436.
4. SOLER P., MOREAU A., BASSET F. & HANCE A.J. (1989) Cigarette smoking-induced changes in the number and differentiated state of pulmonary dendritic cells/Langerhans cells. Am Rev Respir Dis 139, 1112.
5. HOLT P.G. (1993) Regulation of antigen-presenting cell function (s) in lung and airway tissues. Eur Respir J 6, 120.
6. HOLT P.G., SCHON-HEGRAD M.A. & OLIVER J. (1988) MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations. J Exp Med 167, 262.
7. SCHON-HEGRAD M.A., OLIVER J., MCMENAMIN P.G. & HOLT P.G. (1991) Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways. J Exp Med 173, 1345.
8. MCWILLIAM A.S., NELSON D., THOMAS J.A. & HOLT P.G. (1994) Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces. J Exp Med 179, 1331.
9. FOKKENS W.J., VROOM T.M., RIJNTJES E. & MULDER P.G. (1989) Fluctuation of the number of CD-1 (T6)-positive dendritic cells, presumably Langerhans cells, in the nasal mucosa of patients with an isolated grass-pollen allergy before, during, and after the grass-pollen season. J Allergy Clin Immunol 84, 39.
10. MOLLER G.M., OVERBEEK S.E., VAN HELDEN-MEEUWSEN C.G. et al. (1996) Increased numbers of dendritic cells in the bronchial mucosa of atopic asthmatic patients: downregulation by inhaled corticosteroids. Clin Exp Allergy 6, 517.
11. NELSON D.J., MCWILLIAM A.S., HAINING S. & HOLT P.G. (1995) Downmodulation of airway intraepithelial Dendritic Cell populations following local and systemic exposure to steroids. Am J Resp Crit Care Med 151, 475.
12. HOLT P.G., OLIVER J., BILYK N. et al. (1993) Downregulation of the antigen presenting cell function (s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J Exp Med 177, 397.
13. STEINMAN R.M. (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9, 271.
14. POSTON R.N., CHANEZ P., LACOSTE J.Y., LITCHFIELD T., LEE T.H. & BOUSQUET J. (1992) Immunohistochemical characterisation of the cellular infiltration in asthmatic bronchi. Am Rev Respir Dis 145, 918.
15. MASON D.W., ARTHUR R.P., DALLMAN M.J., GREEN J.R., SPICKETT G.P. & THOMAS M.L. (1983) Functions of rat T-lymphocyte subsets isolated by means of monoclonal antibodies. Immunol Rev 74, 57.
16. MOSER M., DE SMEDT T., SORNASSE T. et al. (1995) Glucocorticoids down-regulate dendritic cell function in vitro and in vivo. Eur J Immunol 25, 2818.
17. LINSLEY P.S., BRADY W., GROSMAIRE L.S., DAMLE N.K. & LEDBETTER J.A. (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 174, 561.
18. FISCH A. & RESKE K. (1992) Cell surface display of rat invariant y chain: detection by monoclonal antibodies directed against a C-terminal y chain segment. Eur J Immunol 22, 1413.
19. ARMSTRONG L.R., CHRISTENSEN P.J., PAINE R. et al. (1994) Regulation of the immunostimulatory activity of rat pulmonary interstitial dendritic cells by cell-cell interactions and cytokines. Am J Respir Cell Mol Biol 11, 682.
20. HOLT P.G., HAINING S., NELSON D.J. & SEDGWICK J.D. (1994) Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways. J Immunol 153, 256.
21. CORRIGAN C.J. & KAY A.B. (1992) T-cells and eosinophils in the pathogenesis of asthma. Immunol Today 13, 501.
22. SEMPER A.E. & HARTLEY J.A. (1996) Dendritic cells in the lung: what is their relevance to asthma? (Editorial). Clin Exp Allergy 26, 485.
23. HOLT P.G. (1993) Macrophage:dendritic cell interaction in regulation of the IgE response in asthma (Editorial). Clin Exp Allergy 23, 4.
24. BERMAN B., FRANCE D.S., MARTINELLI G.P. & HASS A. (1983) Modulation of expression of epidermal Langerhans cell properties following in situ exposure to glucocorticosteroids. J Invest Dermatol 80, 168.
25. KÄMPGEN E., GOLD R., EGGERT A. et al. (1995) J Cell Biochem (Suppl) 21 A, 12.
26. ECKELS D.D. (1990) Alloreactivity: allogeneic presentation of endogenous peptide or direct recognition of MHC polymophism? A review. Tissue Antigens 35, 49.