Interleukin-15 strongly inhibits interleukin-8 and monocyte chemoattractant protein-1 production in human colonic epithelial cells

Immunology

Volumn 98, Issue 4, 1999, Pages 504-509

  Lugering N ^a   Kucharzik, T ^a   Maaser, C ^a   Kraft, M ^a   Domschke, W ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN;

ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CELL STRAIN CACO 2; COLON MUCOSA; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FAMILY; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

ANTIBODIES, MONOCLONAL; CACO-2 CELLS; CELLS, CULTURED; CHEMOKINE CCL2; COLON; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; EPITHELIUM; HUMANS; INTERLEUKIN-1; INTERLEUKIN-15; INTERLEUKIN-8; RECEPTORS, INTERLEUKIN-15; RECEPTORS, INTERLEUKIN-2; RECOMBINANT PROTEINS;

EID: 0033406043     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1999.00880.x     Document Type: Article

References (27)

1. 1. BURTON J.D., BAMFORD R.N., PETERS C. et al. (1994) A. lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci USA 94, 4935.
2. 2. GIRI J.G., ANDERSON D.M., KUMAKI S., PARK L.S., GRABSTEIN K.H. & COSMAN D. (1995) IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2. J Leukocyte Biol 57, 763.
3. 3. GIRI J.G., AHDIEH M., EISENMAN J. et al. (1994) Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J 13, 2822.
4. 4. GRABSTEIN K.H., EISENMAN J., SHANEBECK K. et al. (1994) Cloning of a T cell growth factor which interacts with the β chain of the interleukin-2 receptor. Science 264, 965.
5. 5. MORI A., SUKO M., KAMINUMA O. et al. (1996) IL-15 promotes cytokine production of human T helper cells. J Immunol 156, 2400.
6. 6. MCINNES I., AL-MUGHALES J., FIELD M. et al. (1996) The role of interleukin-15 in T cell migration and activation in rheumatoid arthritis. Nature Med 2, 175.
7. 7. ARMITAGE R.J., MACDUFF B.M., EISENMAN J., PAXTON R. & GRABSTEIN K.H. (1995) IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol 154, 483.
8. 8. MCINNES I.B., LEUNG B.P., STURROCK R.D., FIELD M. & LIEW F.Y. (1997) Interleukin-15 mediates T. cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis. Nat Med 2, 189.
9. 9. ONU A., POHL T., KRAUSE H. & BULFONE-PAUS S. (1997) Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms. J Immunol 158, 255.
10. 10. GIRI J.G., KUMAKI S., AHDIEH M. et al. (1995) Identification and cloning of a novel IL-15 binding protein that is structurally related to the apha chain of the IL-2 receptor. EMBO J 14, 3654.
11. 11. ANDERSON D.M., KUMAKI S., AHDIEH M. et al. (1995) Functional characterization of the human interleukin-15 receptor α-chain and close linkage of IL-15RA and IL-2RA genes. J Biol Chem 270, 29862.
12. 12. REINECKER H.C., MACDERMOTT R.P., MIRAU S., DIGNASS A. & PODOLSKY D.K. (1996) Intestinal epithelial cells both express and respond to interleukin-15. Gastroenterology 111, 1706.
13. 13. SAKAI T., KUSUGAMI K.K., NISHIMURA H. et al. (1998) Interleukin-15 activity in the rectal mucosa of inflammatory bowel disease. Gastroenterology 114, 1237.
14. 14. EBERT E.C. (1998) Interleukin-15 is a potent stimulant of intraepithelial lymphocytes. Gastroenterology 115, 1439.
15. 15. KIRMAN I. & NIELSEN O.H. (1996) Increased numbers of interleukin-15-expressing cells in active ulcerative colitis. Am J Gastroenterol 91, 1789.
16. 16. BADOLATO R., PONZI A.N., MILLESIMO M., NOTARANGELO L.D. & MUSSO T. (1997) Interleukin-15 (IL-15) induces IL-8 and monocyte chemotactic protein 1 production in human monocytes. Blood 90, 2804.
17. 17. KUCHARZIK T., LÜGERING N., PAUELS H.G., DOMSCHKE W. & STOLL R. (1998) IL-4, IL-10 and IL. -13 down-regulate monocyte-chemoattracting protein-1 (MCP-1) production in activated intestinal epithelial cells. Clin Exp Immunol 111, 152.
18. 18. DAIG R., ANDUS T., ASCHENBRENNER E., FALK W., SCHÖLMERICH J. & GROSS V. (1996) Increased interleukin-8 expression in the colon mucosa of patients with inflammatory bowel disease. Gut 38, 216.
19. 19. SCHUERER-MALY C.C., ECKMANN L., KAGNOFF M.F., FALCO T. & MALY F.E. (1994) Colonic epithelial cell lines as a source of interleukin-8. stimulation of inflammatory cytokines and bacterial lipopolysaccharide. Immunology 81, 85.
20. 20. LUEGERING N., KUCHARZIK T., KRAFT M., WlNDE G., STOLL R. & DOMSCHKE W. (1999) IL-13 and IL-4 are potent inhibitors of IL-8 regulation by human intestinal epithelial cells. Dig Dis Sci 44, 649.
21. 21. REINECKER H.C., LOH E.Y., RINGLER D.J., MEHTA A., ROMBEAU J.L. & MACDERMOTT R.P. (1995) Monocyte-chemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa. Gastroenterology 108, 40.
22. 22. STEVENS A.C., MATTHEWS J., ANDRES P. et al. (1997) Interleukin-15 signals T84 colonic epithelial cells in the absence of the interleukin-2 receptor β-chain. Am J Physiol 272, G1201.
23. 2+-binding protein MRP8/14. Immunology 91, 130.
24. 24. MACDERMOTT R.P. (1996) Alterations of the mucosa immune system in inflammatory bowel disease. J Gastroenterol 31, 907.
25. 25. DOHERTY T.M., SEDER R.A. & SHER A. (1996) Induction and regulation of IL-15 expression in murine macrophages. J Immunol 156, 735.
26. 26. NISHIMURA H., HIROMATSU K., KOBAYASHI N. et al. (1996) IL-15 is a novel growth factor for murine gamma delta T cells induced by Salmonella infection. J Immunol 156, 663.
27. 27. MCDONALD P., RUSSO M.P., FERRINI S. & CASSATELLA M.A. (1998) Interleukin-15 (IL-15) induces NF-KB activation and IL-8 production in human neutrophils. Blood 92, 4828.