Crry, a complement regulatory protein, modulates renal interstitial disease induced by proteinuria

Kidney International

Volumn 56, Issue 6, 1999, Pages 2096-2106

  Hori, Yuichi ^a,b,c,d   Yamada, Koei ^a,b,c,d   Hanafusa, Norio ^a,b,c,d   Okuda, Toshihiro ^a,b,c,d   Okada, Noriko ^a,b,c,d   Miyata, Toshio ^a,b,c,d   Couser, William G ^a,b,c,d   Kurokawa, Kiyoshi ^a,b,c,d   Fujita, Toshiro ^a,b,c,d   Nangaku, Masaomi ^a,b,c,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^c TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Antisense oligonucleotides; Interstitial nephritis; Nephrotic syndrome; Progressive renal disease

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; COMPLEMENT; COMPLEMENT COMPONENT C3; COMPLEMENT MEMBRANE ATTACK COMPLEX; PUROMYCIN AMINONUCLEOSIDE; REGULATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTERY PERFUSION; ARTICLE; CHRONIC KIDNEY DISEASE; COMPLEMENT DEPOSITION; CONTROLLED STUDY; CYTOLYSIS; GENE REPRESSION; GLOMERULUS; INTERSTITIAL NEPHRITIS; KIDNEY TUBULE CELL; MALE; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RAT;

EID: 0033405957     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1999.00765.x     Document Type: Article

References (87)

1. 1. Risdon RA, Sloper JC, De Wardener HE: Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis. Lancet 2:363-366, 1968
2. 2. Striker GE, Schainuck LI, Cutler RE, Benditt EP: Structural-functional correlations in renal disease. I. A method for assaying and classifying histopathologic changes in renal disease. Hum Pathol 1:615-630, 1970
3. 3. Schainuck LI, Striker GE, Cutler RE, Benditt EP: Structural-functional correlations in renal disease. II. The correlations. Hum Pathol 1:631-640, 1970
4. 4. Bohle A, Glomb D, Grund KE, Mackensen S: Correlations between relative interstitial volume of the renal cortex and serum creatininc concentration in minimal changes with nephrotic syndrome and in focal sclerosing glomerulonephritis. Virchow Arch 376:221-232, 1977
5. 5. Bohle A, Grund KE, Mackensen S, Tolon M: Correlations between renal interstitium and level of serum creatininc: Morphometric investigations of biopsies in perimembranous glomerulonephritis. Virchow Arch 373:15-22, 1977
6. 6. Bohle A, von Gise H, Mackensen-Haen S, Stark-Jacob B: The obliteration of the postglomerular capillaries and its influence upon the function of both glomeruli and tubuli. Klin Wochenschr 59:1043-1051, 1981
7. 7. Mackensen-Haen S, Bader R, Grund KE, Bohle A: Correlations between renal cortical interstitial fibrosis, atrophy of the proximal tubules and impairment of the glomerular filtration rate. Clin Nephrol 15:167-171, 1981
8. 8. Bohle A, Mackensen-Haen S, von Gise H: Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentration ability of the kidney: A morphometric contribution. Am J Nephrol 7:421-433, 1987
9. 9. Bohle A, Wehrmann M, Bogenschütz O, Batz C, Vogi W, Schmitt H, Müller CA, Müller GA: The long-term prognosis of the primary glomerulonephritis: A morphological and clinical analysis of 1747 cases. Pathol Res Pract 188:908-924, 1992
10. 10. Nath KA: Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis 20:1-17, 1992
11. 11. Schwartz MM, Fennell JS, Lewis EJ: Pathologic changes in the renal tubule in systemic lupus crythematosus. Hum Pathol 13:534-547, 1982
12. 12. Alexpoulos E, Seron D, Hartley RB, Cameron JS: Lupus nephritis: Correlation of interstitial cells with glomerular function. Kidney Int 37:100-109, 1990
13. 13. Wehrmann M, Bohle A, Bogenschutz O, Eissele R, Freislederer A, Ohlschlegel C, Schumm G, Batz C, Gartner H-V: Long term prognosis of chronic idiopathic membranous glomerulonephritis: An analysis of 334 cases with particular regard to tubulointerstitial changes. Clin Nephrol 31:67-76, 1989
14. 14. Croker BP, Dawson DV, Sanfilippo F: IgA nephropathy: Correlation of clinical and histologic features. Lab Invest 48:19-24, 1983
15. 15. Katz A, Walker JF, Landy PJ: IgA nephritis with nephrotic range proteinuria. Clin Nephrol 20:67-71, 1983
16. 16. O'Dell JR, Hays RC, Guggenheim SJ, Steigerwald JC: Tubulointerstitial renal disease in systemic lupus crythematosus. Arch Intern Med 145:1996-1999, 1985
17. 17. Okada H, Suzuki H, Konishi K, Sakaguchi H, Saruta T: Histological alterations in renal specimens as indicators of prognosis in IgA nephropathy. Clin Nephrol 37:235-238, 1992
18. 18. Eddy AA: Interstitial nephritis induced by protein-overload proteinuria. Am J Pathol 135:719-733, 1989
19. 19. Eddy AA, McCulloch L, Liu E, Adams J: A relationship between proteinuria and acute tubulointerstitial disease in rats with experimental nephrotic syndrome. Am J Pathol 138:1111-1123, 1991
20. 20. Benigni A, Zoya C, Remuzzi G: Biology of disease: The renal toxicity of sustained glomerular protein traffic. Lab Invest 73:461-468, 1995
21. 21. Eddy AA: Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions. J Am Soc Nephrol 5:1273-1287, 1994
22. 22. Burton C, Harris KPG: The role of proteinuria in the progression of chronic renal failure. Am J Kidney Dis 27:765-775, 1996
23. 23. Bruzzi I, Benigni A, Remuzzi G: Role of increased glomerular protein traffic in the progression of renal failure. Kidney Int 52(Suppl 62):S29-S31, 1997
24. 24. Remuzzi G, Bertani T: Pathophysiology of progressive nephropathies. N Engl J Med 339:1448-1456, 1998
25. 25. Ledingham JGG: Tubular toxicity of filtered proteins. Am J Nephrol 10(Suppl 1):52-57, 1990
26. 26. Alfrey AC, Froment DH, Hammond WS: Role of iron in the tubulo-interstitial injury in nephrotoxic serum nephritis. Kidney Int 36:753-759, 1989
27. 27. Howard RL, Buddington B, Alfrey AC: Urinary albumin, transferrin and iron excretion in diabetic patients. Kidney Int 40:923-926, 1991
28. 28. Thomas ME, Schreiner GF: Contribution of proteinuria to progressive renal injury: Consequences of tubular uptake of fatty acid bearing albumin. Am J Nephrol 13:385-398, 1993
29. 29. Kees-Folts D, Sadow JL, Schreiner GF: Tubular catabolism of albumin is associated with the release of an inflammatory lipid. Kidney Int 45:1697-1709, 1994
30. 30. Morita Y, Nomura A, Yuzawa Y, Nishikawa K, Hotta N, Shimizu F, Matsuo S: The role of complement in the pathogenesis of tubulointerstitial lesions in rat mesangial proliferative glomerulonephritis. J Am Soc Nephrol 8:1363-1372, 1997
31. 31. Nomura A, Morita Y, Maruyama S, Hotta N, Nadai M, Wang L, Hasegawa T, Matsuo S: Role of complement in acute tubulointerstitial injury of rats with aminonucleoside nephrosis. Am J Pathol 151:539-547, 1997
32. 32. Okada H, Tanaka H, Okada N: Prevention of complement activation on the homologous cell membrane of nucleated cells as well as erythrocytes. Eur J Immunol 13:2814-2820, 1983
33. 33. Hebert LA, Cosio FG, Birmingham DJ: The role of complement system in renal injury. Semin Nephrol 12:408-127, 1992
34. 34. Nangaku M, Johnson RJ, Couser WG: Glomerulonephritis and complement regulatory proteins. Exp Nephrol 5:345-354, 1997
35. 35. Morgan BP, Meri S: Membrane proteins that protect against complement lysis. Spring Semin Immunopathol 15:369-396, 1994
36. 36. Parker CJ: Regulation of complement by membrane proteins: An overview. Curr Topics Microbiol Immunol 178:1-6, 1992
37. 37. Asghar SS: Biology of disease: Membrane regulators of complement activation and their aberrant expression in disease. Lab Invest 72:254-271, 1995
38. 38. Molina H, Wong W, Kinoshita T, Brenner C, Foley S, Holers VM: Distinct receptor and regulatory properties of recombinant mouse complement receptor 1 (CR1) and Crry, the two genetic homologues of human CR1. J Exp Med 175:121-129, 1992
39. 39. Kim Y-U, Kinoshita T, Molina H, Hourcade D, Seya T, Wagner LM, Holers VM: Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein. J Exp Med 181:151-159, 1995
40. 40. Quigg RJ, Lo CF, Alexander JJ, Sneed AE III, Moxley G: Molecular characterization of rat Crry: Widespread distribution of two alternative forms of Crry mRNA. Immunogenetics 42:362-367, 1995
41. 41. Sakurada C, Seno H, Dohi N, Takizawa H, Nonaka M, Okada N, Okada H: Molecular cloning of the rat complement regulatory protein, 5I2 antigen. Biochem Biophys Res Commun 198:819-826, 1994
42. 42. Funabashi K, Okada N, Matsuo S, Yamamoto T, Morgan BP, Okada H: Tissue distribution of complement regulatory membrane proteins in rats. Immunology 81:444-451, 1994
43. 43. Okuda T, Yamashita N, Ogata E, Kurokawa K: Angiotensin II and vasopressin stimulate calcium-activated chloride conductance in rat mesangial cells. J Clin Invest 78:1443-1448, 1986
44. 44. Kaname S, Uchida S, Ogata E, Kurokawa K: Autocrine secretion of transforming growth factor-β in cultured rat mesangial cells. Kidney Int 42:1319-1327, 1992
45. 45. Takizawa H, Okada N, Okada H: Complement inhibitor of rat cell membrane resembling mouse Crry/p65. J Immunol 152:3032-3038, 1994
46. 46. Schulze M, Baker PJ, Perkinson DT, Johnson RJ, Ochi RF, Stahl RAK, Couser WG: Increased urinary excretion of C5b-9 distinguishes passive Heymann nephritis in the rat. Kidney Int 35:60-68, 1989
47. 47. Nangaku M, Pippin J, Richardson CA, Schulze M, Young BA, Alpers CE, Gordon KL, Johnson RJ, Couser WG: Beneficial effects of systemic immunoglobulin in experimental membranous nephropathy. Kidney Int 50:2054-2062, 1996
48. 48. Russo C, Callegaro L, Lanza E, Ferrone S: Purification of IgG monoclonal antibody by caprylic acid precipitation. J Immunol Methods 65:269-271, 1983
49. 49. Yagi M, Yamamoto T, Nagano N, Kato S, Kusaka M, Kawasaki K, Yaoita E, Kihara I: Transient expression of type I collagen in glomeruli with anti-Thy-1 antibody-induced mesangial proliferative lesions. Pathol Int 45:409-414, 1995
50. 50. Wroblewski F, LaDue JS: Lactic dehydrogenase activity in blood. Proc Soc Exp Biol Med 90:210-213, 1955
51. 51. Nangaku M, Alpers CE, Pippin J, Shankland SJ, Adler S, Kurokawa K, Couser WG, Johnson RJ: A new model of renal microvascular endothelial injury. Kidney Int 52:182-194, 1997
52. 52. Nangaku M, Meek RL, Pippin J, Gordon KL, Morgan BP, Johnson RJ, Couser WG: Transfected CD59 protects mesangial cells from injury induced by antibody and complement. Kidney Int 50:257-266, 1996
53. 53. Nangaku M, Quigg RJ, Shankland SJ, Okada N, Johnson RJ, Couser WG: Overexpression of Crry protects mesangial cells from complement mediated injury. J Am Soc Nephrol 8:223-233, 1997
54. 54. Oberbauer R, Schreiner GF, Meyer TW: Renal uptake of an 18-mer phosphorothioate oligonucleotide. Kidney Int 48:1226-1232, 1995
55. 55. Carome MA, Kang Y-H, Bohen EM, Nicholson DE, Carr FE, Kiandoli LC, Brummel SE, Yuan CM: Distribution of the cellular uptake of phosphorothioate oligodeoxynucleotides in the rat kidney in vivo. Nephron 75:82-87, 1997
56. 56. Rappaport J, Hanss B, Kopp JB, Copeland TD, Bruggeman LA, Coffman TM, Klotman PE: Transport of phosphorothioate oligonucleotides in kidney: Implications for molecular therapy. Kidney Int 47:1462-1469, 1995
57. 57. Noiri E, Peresleni T, Miller F, Goligorsky MS: In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia. J Clin Invest 97:2377-2383, 1996
58. 58. Marcussen N: Atubular glomeruli and the structural basis for chronic renal failure. Lab Invest 66:265-284, 1992
59. 59. Gandhi M, Olson JL, Meyer TW: Contribution of tubular injury to loss of remnant kidney function. Kidney Int 54:1157-1165, 1998
60. 60. Lange K, Wenk EJ: Complement components in the scra and urine of patients with severe proteinurias. Am J Med Sci 228:448-453, 1954
61. 61. Kjalman A, Avital A, Myers BD: Renal handling of the third (C3) and fourth (C4) components of the complement system in the nephrotic syndrome. Nephron 16:333-343, 1976
62. 62. Camussi G, Stratta P, Mazzucco G, Gaido M, Tetta C, Castello R, Rotunno M, Vercellone A: In vivo localization of C3 on the brush border of proximal tubules of kidneys from nephrotic patients. Clin Nephrol 23:134-141, 1985
63. 63. Camussi G, Rotunno M, Segoloni G, Brentjens JR, Andres GA: In vitro alternative pathway activation of complement by the brush border of proximal tubules of normal rat kidney. J Immunol 128:1659-1663, 1982
64. 64. Camussi G, Tetta C, Mazzuco G, Vercellone A: The brush border of proximal tubules of normal human kidney activates the alternative pathway of the complement system in vitro. Ann NY Acad Sci 420:321-324, 1983
65. 65. Biancone L, David S, Pietra VD, Montrucchio G, Cambi V, Camussi G: Alternative pathway activation of complement by cultured human proximal tubular epithelial cells. Kidney Int 45:451-460, 1994
66. 66. Sato K, Ullrich KJ: Serum-induced inhibition of isotonic fluid absorption by the kidney proximal tubule. I. Mechanism of inhibition. Biochim Biophys Acta 343:609-614, 1974
67. 67. Hughes TR, Meri S, Davies M, Williams JD, Morgan BP: Immunolocalization and characterization of the rat analogue of human CD59 in kidney and glomerular cells. Immunology 80:439-444, 1993
68. 68. Matsuo S, Nishikage H, Yoshida F, Nomura A, Piddlesden SJ, Morgan BP: Role of CD59 in experimental glomerulonephritis in rats. Kidney Int 46:191-200, 1994
69. 69. Nishikage H, Baranyi L, Okada H, Okada N, Isobe K, Nomura A, Yoshida F, Matsuo S: The role of a complement regulatory protein in rat mesangial glomerulonephritis. J Am Soc Nephrol 6:234-242, 1995
70. 70. Quigg RJ, Morgan BP, Holers VM, Adler S, Sneed AE III, Lo CF: Complement regulation in the rat glomerulus: Crry and CD59 regulate complement in glomerular mesangial and endothelial cells. Kidney Int 48:412-421, 1995
71. 71. Quigg RJ, Holers VM, Morgan BP, Sneed AE III: Crry and CD59 regulate complement in rat glomerular epithelial cells and are inhibited by the nephritogenic antibody to passive Heymann nephritis. J Immunol 154:3437-3443, 1995
72. 72. Quigg RJ, He C, Lim A, Berthiaume D, Alexander JJ, Kraus D, Holers VM: Transgenic mice overexpressing the complement inhibitor Crry as a soluble protein are protected from antibody-induced glomerular injury. J Exp Med 188:1321-1331, 1998
73. 73. Schiller B, He C, Salant DJ, Lim A, Alexander JJ, Quigg RJ: Inhibition of complement regulation is key to the pathogenesis of active Heymann nephritis. J Exp Med 188:1353-1358, 1998
74. 74. Nangaku M: Complement regulatory proteins in glomerular diseases. Kidney Int 54:1419-1428, 1998
75. 75. Scanlon KJ, Ohta Y, Ishida H, Kijima H, Ohkawa T, Kaminski A, Tsai J, Horng G, Kashani-Sabet M: Oligonucleotide-mediated modulation of mammalian gene expression. FASEB J 9:1288-1296, 1995
76. 76. Milligan JF, Matteucci MD, Martin JC: Current concepts in antisense drug design. J Med Chem 36:1923-1937, 1993
77. 77. Neckers L, Whitesell L: Antisense technology: Biological utility and practical considerations. Am J Physiol 265:L1-L12, 1993
78. 78. Wagner RW: Gene inhibition using antisense oligonucleotides. Nature 372:333-335, 1994
79. 79. Askari FK, McDonnell WM: Molecular medicine: Antisenseoligonucleotide therapy. N Engl J Med 334:316-318, 1996
80. 14C-labeled phosphorothioate oligonucleotide, ISIS 2105, after intradermal administration to rats. J Pharmacol Exp Ther 269:89-94, 1994
81. 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats. J Pharmacol Exp Ther 267: 1181-1190, 1993
82. 82. Agrawal S, Temsamani J, Tang JY: Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice (antisense inhibition of gene expression/antiviral therapy/ oligodeoxynucleotide uptake/human immunodeficiency virus). Proc Natl Acad Sci USA 88:7595-7599, 1991
83. 83. Nomura A, Nishikawa K, Yuzawa Y, Okada H, Okada N, Morgan BP, Piddlesden SJ, Nadai M, Hasegawa T, Matsuo S: Tubulointerstitial injury induced in rats by a monoclonal antibody that inhibits function of a membrane inhibitor of complement. J Clin Invest 96:2348-2356, 1995
84. 84. Matsuo S, Ichida S, Takizawa H, Okada N, Baranyi L, Iguchi A, Morgan BP, Okada H: In vivo effects of monoclonal antibodies which functionally inhibit complement regulatory proteins in rats. J Exp Med 180:1619-1627, 1994
85. 85. Hatanaka Y, Yuzawa Y, Nishikawa K, Fukatsu A, Okada N, Okada H, Mizuno M, Matsuo S: Role of a rat membrane inhibitor of complement in anti-basement membrane antibody-induced renal injury. Kidney Int 48:1728-1737, 1995
86. 86. Gröne H-J, Weber K, Gröne E, Helmchen U, Osborn M: Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney. Am J Pathol 129:1-8, 1987
87. 87. Eddy AA, Giachelli CM: Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria. Kidney Int 47:1546-1557, 1995