Transfected CD59 protects mesangial cells from injury induced by antibody and complement

Kidney International

Volumn 50, Issue 1, 1996, Pages 257-266

  Nangaku, Masaomi ^b   Meek, Rick L ^b   Pippin, Jeffrey ^b   Gordon, Katherine L ^b   Morgan, B Paul ^b   Johnson, Richard J ^b   Couser, William G ^a  

^a UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CALCIMYCIN; CD59 ANTIGEN; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; INTERLEUKIN 1BETA; PHORBOL 13 ACETATE 12 MYRISTATE; REGULATOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN EXPRESSION; ARTICLE; CELL PROTECTION; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; IMMUNOPATHOLOGY; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029808258     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1996.310     Document Type: Article

References (59)

1. COUSER WG: Mechanisms of glomerular injury in immune-complex disease. Kidney Int 28:569-583, 1985
2. HEBERT LA, COSIO FG, BIRMINGHAM DJ: The role of complement system in renal injury. Semin Nephrol 12:408-427, 1992
3. COUSER WG: The pathogenesis of glomerulonephritis. Kidney Int 44(Suppl 42):S19-S26, 1993
4. COUSER WG, SCHULZE M, PRUCHNO CJ: Role of C5b-9 in experimental membranous nephropathy. Nephrol Dial Transplant 7(Suppl 1): S25-S31, 1992
5. CYBULSKY AV, RENNKE HG, FEINTZEIG ID, SALANT DJ: Complement-induced glomerular epithelial cell injury. Role of the membrane attack complex in rat membranous nephropathy. J Clin Invest 77: 1096-1107, 1986
6. BAKER PJ, OCHI RF, SCHULZE M, JOHNSON RJ, CAMPBELL C, COUSER WG: Depletion of C6 prevents development of proteinuria in experimental membranous nephropathy in rats. Am J Pathol 135:185-194, 1989
7. SAVIN VJ, JOHNSON RJ, COUSER WG: C5b-9 increases albumin permeability of isolated glomeruli in vitro. Kidney Int 46:382-387, 1994
8. BRANDI J, PIPPIN J, SCHULZE M, HÄNSCH GM, ALPERS C, JOHNSON RJ, GORDON K, COUSER WG: Role of the complement membrane attack complex (C5b-9) in mediating experimental mesangioproliferative glomerulonephritis. Kidney Int (in press)
9. KERJASCHKI D, SCHULZE M, BINDER S, KAIN R, OJHA PP, SUANI M, HORVAT H, BAKER PJ, COUSER WG: Transcellular transport; and membrane insertion of the C5b-9 membrane attack complex of complement by glomerular epithelial cells in experimental membranous nephropathy. J Immunol 143:546-552, 1989
10. HÄNSCH GM, SCHIEREN G, WAGNER C, SCHÖNERMARK M: Immune damage to the mesangium: Antibody- and complement-mediated stimulation and destruction of mesangial cells. J Am Soc Nephrol 2(Suppl 2):S139-S143, 1992
11. MORGAN BP, MERI S: Membrane proteins that protect against complement lysis. Springer Sem Immunopathol 15:369-396, 1994
12. ROLLINS SA, SIMS PJ: The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9. J Immunol 144:3478-3483, 1990
13. HUGHES TR, MERI S, DAVIES M, WILLIAMS JD, MORGAN BP: Immunolocalization and characterization of the rat analogue of human CD59 in kidney and glomerular cells. Immunology 80:439-444. 1993
14. QUIGG RJ, MORGAN BP, HOLERS VM, ADLER S, SNEED AE III, LO CF: Complement regulation in the rat glomerulus: Crry and CD59 regulate complement in glomerular mesangial and endothelial cells. Kidney Int 48:412-421, 1995
15. MATSUO S, NISHIKAGE H, YOSHIDA F, NOMURA A, PIDDLESDEN SJ, MORGAN BP: Role of CD59 in experimental glomerulonephritis in rats. Kidney Int 46:191-200, 1994
16. RUSHMERE NK, HARRISON RA, VEN DEN BERG CW, MORGAN BP: Molecular cloning of the rat analogue of human CD59: Structural comparison with human CD59 and identification of a putative active site. Biochem J 304:595-601, 1994
17. YEH ETH, KAMITANI T, CHANG HM: Biosynthesis and processing of the glycosylphosphatidylinositol anchor in mammalian cells. Semin Immunol 6:73-80, 1994
18. NIWA H, YAMAMURA K, MIYAZAKI J: Efficient selection for high-expression transfectants by a novel eukaryotic vector. Gene 108:193-200, 1991
19. MCHUGH KM, LESSARD JL: The nucleotide sequence of a rat vascular smooth muscle α-actin cDNA. Nucl Acid Res 16:4167, 1988
20. ADLER S, BAKER PJ, JOHNSON RJ, OCHI RF, PRITZL P, COUSER WG: Complement membrane attack complex stimulates production of reactive oxygen metabolites by cultured rat mesangial cells. J Clin Invest 77:762-767, 1986
21. SAMBROOK J, FRITSCH EF, MANIATIS T: Expression of cloned genes in cultured mammalian cells, in Molecular Cloning. A Laboratory Manual (2nd ed), New York, Cold Spring Harbor Laboratory Press, 1989, pp 16.1-16.81
22. HUGHES TR, PIDDLESDEN SJ, WILLIAMS JD, HARRISON RA, MORGAN BP: Isolation and characterization of a membrane protein from rat erythrocytes which inhibits lysis by the membrane attack complex of rat complement. Biochem J 284:169-176, 1992
23. RUSSO C, CALLEGARO L, LANZA E, FERRONE S: Purification of IgG monoclonal antibody by caprylic acid precipitation. J Immunol Meth 65:269-271, 1983
24. LEENAERTS PL, STAD RK, HALL BM, VAN DAMME BJ, VAN RENTERGAGM Y, DAHA MR: Hereditary C6 deficiency in a strain of PVG/c rats. Clin Exp Immunol 97:478-482, 1994
25. SCHULZE M, BAKER PJ, PERKINSON DT, JOHNSON RJ, OCHI RF, STAHL RAK, COUSER WG: Increased urinary excretion of C5b-9 distinguishes passive Hermann nephritis in the rat. Kidney Int 35:60-68, 1989
26. SALANT DJ, QUIGG RJ, CYBULSKY AV: Heymann nephritis: Mechanisms of renal injury. Kidney Int 35:976-984, 1989
27. BIESECKE G, KATZ S, KOFFLER D: Renal localization of the membrane attack complex in systemic lupus erythematosus nephritis. J Exp Med 154:1779-1794, 1981
28. FALK RJ, DALMASSO AP, KIM Y, TSAI CH, SCHEINMAN JI, GEWURZ H, MICHAEL AF: Neoantigen of the polymerized ninth component of complement. Characterization of a monoclonal antibody and immunohistochemical localization in renal disease. J Clin Invest 72:560-573, 1983
29. HINGLAIS N, KAZATCHKINE MD, BHAKDI S, APPAY M-D, MANDET C, GROSSETETE J, BARIETY J: Immunohistochemical study of the C5b-9 complex of complement in human kidneys. Kidney Int 30:399-410. 1986
30. MIYAMOTO H, YOSHIOKA K, TAKEMURA T, AKANO N, MAKI S: Immunohistochemical study of the membrane attack complex of complement in IgA nephropathy. Virchows Arch 413:77-86, 1988
31. KAWANA S, SHEN GH, KOBAYASHI Y, NISHIYAMA S: Membrane attack complex of complement in Henoch-Schönlein purpura skin and nephrits. Arch Dermatol Res 282:183-187, 1990
32. OKADA M, YOSHIOKA K, TAKEMURA T, AKANO N, AYA N, MURAKAMI K, MAKI S: Immunohistochemical localization of C3 days fragment of complement and S-protein (vitronectin) in normal and diseased human kidneys: Association with the C5b-9 complex and vitronectin receptor. Virchows Arch 422:367-373, 1993
33. SUGITA Y, NAKANO Y, TOMITA M: Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels. J Biochem 104:633-637, 1988
34. OKADA N, HARADA R, FUJITA T, OKADA H: A novel membrane glycoprotein capable of inhibiting membrane attack by homologous complement. Int Immunol 1:205-208, 1989
35. HOLGUIN MH, FREDRICK LR, BERNSHAW NJ, WILCOX LA, PARKER CJ: Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria. J Clin Invest 84:7-17, 1989
36. DAVIES SJ, SIMMONS DL, HALE G, HARRISON RA, TIGHE H, LACHMANN PJ, WALDMANN H: CD59, an Ly-6 like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. J Exp Med 170:637-654, 1989
37. MERI S, MORGAN BP, DAVIES A, DANIELS RH, OLAVESEN MG, WALDMANN H, LACHMANN PJ: Human protectin (CD59), and 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers. Immunology 71:1-9, 1990
38. QUIGG RJ, HOLERS VM, MORGAN BP, SNEED AE III: Crry and CD59 regulate complement in rat glomerular epithelial cells and are inhibited by the nephritogenic antibody to passive Heymann nephritis. J Immunol 154:3437-3443, 1995
39. TAMAI H, MATSUO S, FUKATSU A, NISHIKAWA K, SAKAMOTO N, YOSHIHOKA K, OKADA N, OKADA H: Localization of 20-kD homologous restriction factor (HRF20) in diseased human glomeruli. An immunofluorescence study. Clin Exp Immunol 84:256-262, 1991
40. ICHIDA S, YUZAWA Y, OKADA H, YOSHIOKA K, MATSUO S: Localization of the complement regulatory proteins in the normal human kidney. Kidney Int 46:89-96, 1994
41. YAMAMOTO T, WILSON CB: Quantitative and qualitative studies of antibody-induced mesangial cell damage in the rat. Kidney Int 32:514-525, 1987
42. YAMAMOTO T, WILSON CB: Complement dependence of antibody-induced mesangial cell injury in the rat. J Immunol 138:3758-3765, 1987
43. JOHNSON RJ, PRITZL P, IIDA H, ALPERS CE: Platelet-complement interactions in mesangial proliterative nephritis in the rat. Am J Pathol 138:313-321, 1991
44. COUSER WG, JOHNSON RJ, YOUNG BA, YEH G, TOTH CA, RUDOLPH AR: The effects of soluble recombinant complement receptor 1 on complement-mediated experimental glomerulonephritis. J Am Soc Nephrol 5:1888-1894, 1995
45. ZHAO J, ROLLINS SA, MAHER SE, BOTHWELL ALM, SIMS PJ: Amplified gene expression in CD59-transfected Chinese hamster ovary cells confers protection against the membrane attack complex of human complement. J Biol Chem 266:13418-13422, 1991
46. WALSH LA, TONE M, WALDMANN H: Transfection of human CD59 complementary DNA into rat cells confers resistance to human complement. Eur J Immunol 21:847-850, 1991
47. SOMERVILLE CA, KYRIAZIS AG, MCKENZIE A, ALLISON J, PEARSE MJ, D'APICE AJF: Functional expression of human CD59 in transgenic mice. Transplantation 58:1430-1435, 1994
48. KENNEDY SP, ROLLINS SA, BURTON WV, SIMS PJ, BOTHWELL ALM, SQUINTO SP, ZAVOICO GB: Protection of porcine aortic endothelial cells from complement-mediated cell lysis and activation by recombinant human CD59. Transplantation 57:1494-1501, 1994
49. FODOR WL, WILLIAMS BL, MATIS LA, MADRI JA, ROLLINS SA, KNIGHT JW, VALANDER W, SOUIMO SP: Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection. Proc Natl Acad Sci USA 91:11153-11157, 1994
50. LOVETT DH, HÄNSCH GM, GOPPELT M, RESCH K, GEMSA D: Activation of glomerular mesangial cells by the terminal membrane attack complex of complement. J Immunol 138:2473-2480, 1987
51. TORBOHM I, SCHONERMARK M, WINGEN AM, BERGER B, ROTHER K, HÄNSCH GM: C5b-8 and C5b-9 modulate the collagen release of human glomerular epithelial cells. Kidney Int 37:1098-1104, 1990
52. SCHÖNERMARK M, DEPPISCH R, RIEDASCH G, ROTHER K, HÄNSCH GM: Induction of mediator release from human glomerular mesangial cells by the terminal membrane attack complex components C5b-9. Int Arch Allergy Appl Immunol 96:331-337, 1991
53. SHAH SV: Role of reactive oxygen metabolites in experimental glomerular disease. Kidney Int 35:1093-1106, 1989
54. 558 are produced by kidney glomerular cells in passive Heymann nephritis. Proc Natl Acad Sci USA 90:3645-3649, 1993
55. RADEKE HH, MEIRE B, TOPLEY N, FLÖGE J, HABERMEHL GG, RESCH K: Interleukin 1-alpha and tumor necrosis factor-alpha induce oxygen radical. Kidney Int 37:765-775, 1990
56. 558 and 45-kDa flavoprotein) by intrinsic human glomerular mesangial cells. J Biol Chem 266:21025-21029, 1991
57. JONES SA, HANCOCK JT, JONES OTG, NEUBAUER A, TOPLEY N: The expression of NADPH oxidase components in human glomerular mesangial cells: Detection of protein and mRNA for p47phox, p67phox, and p22phox. Am J Soc Nephrol 5:1483-1491, 1995
58. SHIBATA T, KOHSAKA T: Effects of complement activation on the expression of CD59 by human mesangial cells. J Immunol 155:403-409, 1995
59. SUGITA Y, ITO K, SHIOZUKA H, SUZUKI H, GUSHIMA M, TOMITA M, MASUHO Y: Recombinant soluble CD59 inhibits reactive haemolysis with complement. Immunology 82:34-41, 1994