Domain necessary for drosophila ELAV nuclear localization: Function requires nuclear ELAV

Journal of Cell Science

Volumn 112, Issue 24, 1999, Pages 4501-4512

  Yannoni, Yvonne M ^a,b   White, Kalpana ^b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRANDEIS UNIVERSITY   (United States)

Author keywords

Genetic complementation; Hu protein; Neuronal protein; Nuclear localization; RNA binding

Indexed keywords

MUTANT PROTEIN; RNA BINDING PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; DROSOPHILA; EMBRYO; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RNA TRANSLATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL NUCLEUS; DNA PRIMERS; DROSOPHILA MELANOGASTER; GREEN FLUORESCENT PROTEINS; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; LUMINESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; MUTAGENESIS, SITE-DIRECTED; RIBONUCLEOPROTEINS; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0033402460     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Abe, R., Sakashita, E., Yamamoto, K. and Sakamoto, H. (1996). Two different RNA binding activities for the AU-rich element and the poly(A) sequence of the mouse neuronal protein mHuC. Nucl. Acids Res. 24, 4895-4901.
2. Afonina, E., Stauber, R. and Pavlakis, G. N. (1998). The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm. J. Biol. Chem. 273, 13015-13021.
3. Antic, D. and Keene, J. D. (1997). Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression. Am. J. Hum. Genet. 61, 273-278.
4. Antic, D. and Keene, J. D. (1998). Messenger ribonucleoprotein complexes containing human ELAV proteins: interactions with cytoskeleton and translational apparatus. J. Cell Sci. 111, 183-197.
5. Antic, D., Lu, N. and Keene, J. (1999) ELAV tumor antigen. Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells. Genes Dev. 13, 449-461
6. Atasoy, U., Watson, J., Patel, D. and Keene, J. D. (1998). ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. J. Cell Sci. 111, 3145-3156.
7. Bernstein, P., Peltz, S. W. and Ross, J. (1989). The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro. Mol. Cell Biol. 9, 659-670.
8. Brand, A. H. and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
9. Burd, C. G. and Dreyfuss, G. (1994). Conserved structures and diversity of functions of RNA binding proteins. Science 265, 615-621.
10. Campos, A.-R., Grossman, D. and White, K. (1985). Mutant alleles at the locus elav in Drosophila melanogaster lead to nervous system defects. A developmental-genetic analysis. J. Neurogen. 2, 197-218.
11. Chelsky, D., Ralph, R. and Jonak, G. (1989). Sequence requirements for synthetic peptide-mediated translocation to the nucleus. Mol. Cell. Biol. 9, 2487-2492.
12. Chen, X. S., Zhang, Y. Y. and Funk, C. D. (1998). Determinants of 5-lipoxygenase nuclear localization using green fluorescent protein/5-lipoxygenase fusion proteins. J. Biol. Chem. 273, 31237-31244.
13. Davis, I., Girdham, C. H. and O'Farrell, P. H. (1995). A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence. Dev. Biol. 170, 726-729.
14. Fan, X. C. and Steitz, J. A. (1998a). HNS, a nuclear-cytoplasmic shuttling sequence in HuR. Proc. Nat. Acad. Sci. USA 95, 15293-15298.
15. Fan, X. C. and Steitz, J. A. (1998b). Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs. EMBO J. 17, 3448-3460.
16. Gao, F. B. and Keene, J. D. (1996). Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation. J. Cell Sci. 109, 579-589.
17. Good, P. J. (1995). A conserved family of elav-like genes in vertebrates. Proc. Nat. Acad. Sci. USA 92, 4557-4561.
18. Gorlich, D. and Mattaj, I. W. (1996). Nucleocytoplasmic transport. Science 271, 1513-1518.
19. Jain, R. G., Andrews, L. G., McGowan, K. M., Pekala, P. H. and Keene, J. D. (1997). Ectopic expression of Hel-N1, an RNA-binding protein. increases glucose transporter (GLUT1) expression 3T3-L1 adipocytes. Mol. Cell. Biol. 17, 954-962.
20. Kalderon, D., Roberts, B. L., Richardson, W. D. and Smith, A. E. (1984). A short amino acid sequence able to specify nuclear location. Cell 39, 499-509.
21. Keene, J. D. (1999). Why is Hu where? Shuttling of early-response-gene messenger RNA subsets. Proc. Nat. Acad. Sci. USA 96, 5-7.
22. King, P. H., Levine, T. D., Fremeau, R. T. Jr., Keene, J. D. (1994a). Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3′ UTR of mRNA encoding the Id transcriptional repressor. J. Neurosci. 14, 1943-1952.
23. King, P. H. (1994b) Hel-N2: a novel isoform of Hel-N1 which is conserved in rat neural tissue and produced in early embryogenesis. Gene 151, 261-265.
24. Kim, J. K. and Baker, B. S. (1993). The Drosophila gene rbp9, encodes a protein that is a member of a conserved group of putative RNA binding proteins that are nervous-system specific in both flies and humans. J. Neurosci. 14, 1943-1952.
25. Koushika, S. P., Lisbin, M. J. and White, K. (1996). ELAV, a Drosophila neuron-specific protein, mediates the generation of an alternatively spliced neural protein isoform. Curr. Biol. 6, 1634-1641.
26. Koushika, S. P. (1998). Identification of genes regulated by the Drosophila melanogaster neuron-specific ELAV protein. Ph.D. thesis, Brandeis University, Waltham, MA, USA
27. Lin, D. M. and Goodman, C. S. (1994). Ectopic and increased expression of Fasciclin Il alters motorneuron growth cone guidance. Neuron 13, 507-523.
28. Liu, J., Dalmau, J., Szabo, A., Rosenfeld, M., Huber, J. and Furneaux, H. (1995). Paraneoplastic encephalomyelitis antigens bind to the AU-rich elements of mRNA. Neurology 45, 544-550.
29. Luo, L., Liao, Y. J., Jan, L. Y. and Jan, Y. N. (1994). Distinct morphogenetic functions of similar small GTPases: Drosophila Drac 1 is involved in axonal outgrowth and myoblast fusion. Genes Dev. 8, 1787-1802.
30. Marusich, M. F., Furneaux, H. M., Henion, P. D. and Weston, J. A. (1994) Hu neuronal proteins are expressed in proliferating neurogenic cells. J. Neurobiol. 25, 143-155.
31. Michael, W. M., Choi, M. and Dreyfuss, G. (1995). A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell 83, 415-422.
32. Mottes, J. R. and Iverson, L. E. (1995). Tissue-specific alternative splicing of hybrid Shaker/lacZ genes correlates with kinetic differences in Shaker K+ currents in vivo. Neuron 14, 613-623.
33. Myer, V. E., Fan, X. C. and Steitz, J. A. (1997). Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay. EMBO J. 16, 2130-2139.
34. Nigg, E. A. (1997). Nucleocytoplasmic transport: signals, mechanisms and regulation. Nature 386, 779-787.
35. O'Farrell, P. H. and Girdham, C. H. (1994). The use of photoactivatible reagents for the study of cell lineage in Drosophila embryogenesis. Meth. Cell Biol. 44, 533-541.
36. Okano, H. J. and Darnell, R. B. (1997). A hierarchy of Hu RNA binding proteins in developing and adult neurons. J. Neurosci. 17, 3024-3037.
37. Park, S. J., Yang, E. S., Kim-Ha, J. and Kim, Y. J. (1998). Down regulation of extramacrochaetae mRNA by a Drosophila neural RNA binding protein Rbp9 which is homologous to human Hu proteins. Nucl. Acids Res. 26, 2989-2994.
38. Peng, S. S., Chen, C. Y., Xu, N. and Shyu, A. B. (1998). RNA stabilization by the AU-rich element binding protein. HuR, an ELAV protein. EMBO J. 17, 3461-3470.
39. Perron, M., Bourlitio, P., Wegnez, M. and Theodore, L. (1997). Subcellular distribution of Xenopus XEL-1 protein, a member of the neuron-specific ELAV/Hu family, revealed by epitope tagging. DNA Cell Biol. 16, 579-587.
40. Pirrotta, V. (1988). Vectors for p-mediated transformation in Drosophila. In Vectors: a Survey of Molecular Cloning Vectors and their Uses (ed. R. L. Rodriguez and D. T. Denhardt), pp. 437-456, Boston: Butterworths.
41. Prieve, M. G., Guttridge, K. L., Munguia, J. E. and Waterman, M. L. (1996). The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins. J. Biol. Chem. 271, 7654-7658.
42. Richardson, W. D., Roberts, B. L. and Smith, A. E. (1986). Nuclear location signals in polyoma virus large-T. Cell 44, 77-85.
43. Robertson, H. M., Preston, C. R., Phillis, R. W., Johnson-Schlitz, D. M., Benz, W. K. and Engels, W. R. (1988). A stable genomic source of P-element transposase in Drosophila melanogaster. Genetics 118, 461-470.
44. Robinow, S. and White, K. (1991). Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development. J. Neurobiol. 22, 443-461.
45. Rubin, G. M. and Spradling, A. C. (1982). Genetic transformation of Drosophila with transposable element vectors. Science 218, 348-353.
46. Ruskin, B., Zamore, P. D. and Green, M. R. (1988). A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly. Cell 52, 207-219.
47. Samson, M.-L., Lisbin, M. J. and White, K. (1995). Two distinct temperature-sensitive alleles at the elav locus of Drosophila are suppressed nonsense mutations of the same tryptophan codon. Genetics 141, 1101-1111.
48. Samson, M. L. (1998). Evidence for 3′ untranslated region-dependent autoregulation of the Drosophila gene encoding the neuronal nuclear RNA-binding protein ELAV. Genetics 150, 723-733.
49. Silver, P. A. (1991). How proteins enter the nucleus. Cell 64, 489-497.
50. Stade, K., Ford, C. S., Guthrie, C. and Weis, K. (1997). Exportin 1 (Crm1p) is an essential nuclear export factor. Cell 90, 1041-1050.
51. Szabo, A., Dalmau, J., Manley, G., Rosenfeld, M., Wong, E., Henson, J., Posner, J. B. and Furneaux, H. M. (1991). HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to ELAV and Sex-lethal. Cell 67, 325-333.
52. Wakamatsu, Y. and Weston, J. A. (1997). Sequential expression and role of Hu RNA-binding proteins during neurogenesis. Development 124, 3449-3460.
53. Wu, L., Good, P. J. and Richter, J. D. (1997). The 36-kilodalton embryonic-type cytoplasmic polyadenylation element-binding protein in Xenopus laevis is ElrA, a member of the ELAV family of RNA-binding proteins. Mol. Cell Biol. 17, 6402-6409.
54. Yannoni, Y. M. and White, K. (1997). Association of the neuron-specific RNA binding domain-containing protein ELAV with the coiled body in Drosophila neurons. Chromosoma 105, 332-341.
55. Yao, K.-M., Samson, M.-L., Reeves, R. and White, K. (1993). Gene elav of Drosophila melanogaster: a prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans. J. Neurobiol. 24, 723-739.
56. Yao, K.-M. and White, K. (1991). Organizational analysis of elav gene and functional analysis of ELAV protein of Drosophila melanogaster and Drosophila virilis. Mol. Cell. Biol. 11, 2994-3000.