Expression of Bcl-2 protein in hyperplastic polyps, adenomas, and carcinomas of the colon

Journal of Pathology

Volumn 178, Issue 4, 1996, Pages 393-397

  Flohil, Claudie C ^a   Janssen, Patrick A ^a   Bosman, Fred T ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

Adenoma; Bcl 2; Carcinoma; Colon; MIB 1

Indexed keywords

PROTEIN BCL 2;

ARTICLE; COLON ADENOMA; COLON CARCINOMA; COLON POLYP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ADENOMA; ANTIBODY SPECIFICITY; BLOTTING, WESTERN; CARCINOMA; COLON; COLONIC NEOPLASMS; COLONIC POLYPS; DISEASE PROGRESSION; HUMANS; HYPERPLASIA; IMMUNOENZYME TECHNIQUES; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0029868847     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199604)178:4<393::AID-PATH488>3.0.CO;2-G     Document Type: Article

References (20)

1. Tsujimoto Y, Croce CM. Analysis of the structure, transcripts and protein products of bcl-2, the gene involved in human follicular lymphoma Proc Natl Acad Sci USA 1986, 83: 5214-5128.
2. Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM. Cloning of the chromosome breakpoint of neoplastic B-cells with the t(14;18) chromosome translocation. Science 1984; 226: 1097-1099
3. Bakhshi A, Jensen JP, Goldman P, et al. Cloning of the chromosomal-breakpoint of t(14,18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 1985, 41: 899-906
4. Chen-Levy Z, Nourse J, Cleary M. The bcl-2 candidate protooncogene product is a 24-kilodalton integral membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14-18) translocation. Mol Cell Biol 1989; 9: 701-710.
5. Hockenbery DM, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990; 348: 334-336.
6. Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes hematopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1988, 335: 440-442.
7. McDonnell TJ, Deane N, Platt FM, et al. Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 1989; 57: 79-88
8. McDonnell TJ, Nunez G, Platt F, et al. Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B cell population Mol Cell Biol 1990; 10: 1901-1907.
9. Pietenpol JA, Papadopoulos N, Markowitz S, Willson JK, Kinzler KW, Vogelstein B. Paradoxical inhibition of solid tumor cell growth by bcl2. Cancer Res 1994; 54: 3714-3717
10. Lu Q-L, Poulsom R, Wong L, Hanby AM Bcl-2 expression in adult and embryonic non-hematopoietic tissues. J Pathol 1993; 169: 431-437.
11. LeBrun D, Warnke RA, Cleary ML. Expression of Bcl-2 in fetal tissues suggests a role in morphogenesis. Am J Pathol 1993; 142: 743-753.
12. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ. Bcl-2 protein is topographically restricted to tissues characterized by apoptotic cell death Proc Natl Acad Sci USA 1990; 87: 6961-6965.
13. Colombel M, Symmans F, Gil S, et al. Detection of the apoptosis-suppressing oncoprotein Bcl-2 in hormone-refractory human prostate cancers. Am J Pathol 1993; 143: 390-400
14. Pezzella F, Turley H, Kuzu I, et al. Bcl-2 protein in non-small-cell lung carcinoma. N Engl J Med 1993; 329: 690-694.
15. Pilotti S, Collini P, Rilke F, Cattoretti G, Del Bo R, Pierotti MA. Bcl-2 protein expression in carcinomas originating from the follicular epithelium of the thyroid gland. J Pathol 1994, 172: 337-342.
16. Ramani P, Lu Q-L. Expression of Bcl-2 gene product in neuroblastoma. J Pathol 1994; 172: 273-278.
17. Ben-Ezra JM, Kornstein MJ, Grimes MM, Krystal G. Small cell carcinomas of the lung express the Bcl-2 protein. Am J Pathol 1994; 145: 1036-1040.
18. Joensuu H, Pylkkänen L, Toikkanen S. Bcl-2 protein expression and long-term survival in breast cancer. Am J Pathol 1994; 145: 1191-1198.
19. Hague A, Moorghen M, Hicks D, Chapman M, Paraskeva C Bcl-2 expression in human colorectal adenomas and carcinomas. Oncogene 1994; 9: 3367-3370.
20. Bosari S, Moneghini L, Graziani D, et al. Bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas and adenocarcinomas. Hum Pathol 1995; 26: 534-540.